ID:IFI27_HUMAN DESCRIPTION: RecName: Full=Interferon alpha-inducible protein 27, mitochondrial; Short=p27; AltName: Full=Interferon alpha-induced 11.5 kDa protein; AltName: Full=Interferon-stimulated gene 12a protein; Short=ISG12(a); Flags: Precursor; FUNCTION: Promotes cell death. Mediates IFN-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9. SUBCELLULAR LOCATION: Mitochondrion. Membrane; Multi-pass membrane protein (Potential). INDUCTION: Up-regulated by interferons. SIMILARITY: Belongs to the IFI6/IFI27 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06140 - Interferon-induced 6-16 family
ModBase Predicted Comparative 3D Structure on P40305
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006915 apoptotic process GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0046825 regulation of protein export from nucleus GO:0060337 type I interferon signaling pathway GO:0097190 apoptotic signaling pathway