Human Gene HSPE1 (ENST00000233893.10_4) from GENCODE V47lift37
  Description: heat shock protein family E (Hsp10) member 1 (from RefSeq NM_002157.3)
Gencode Transcript: ENST00000233893.10_4
Gencode Gene: ENSG00000115541.11_8
Transcript (Including UTRs)
   Position: hg19 chr2:198,365,103-198,368,173 Size: 3,071 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr2:198,365,161-198,367,983 Size: 2,823 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:198,365,103-198,368,173)mRNA (may differ from genome)Protein (102 aa)
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-  Comments and Description Text from UniProtKB
  ID: CH10_HUMAN
DESCRIPTION: RecName: Full=10 kDa heat shock protein, mitochondrial; Short=Hsp10; AltName: Full=10 kDa chaperonin; AltName: Full=Chaperonin 10; Short=CPN10; AltName: Full=Early-pregnancy factor; Short=EPF;
FUNCTION: Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
SUBUNIT: Homohexamer.
INTERACTION: P49789:FHIT; NbExp=4; IntAct=EBI-711483, EBI-741760;
SUBCELLULAR LOCATION: Mitochondrion matrix.
INDUCTION: By stress.
MASS SPECTROMETRY: Mass=10843.5; Mass_error=0.2; Method=Electrospray; Range=2-102; Source=PubMed:7912672;
SIMILARITY: Belongs to the GroES chaperonin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HSPE1
Diseases sorted by gene-association score: exocervical carcinoma (17), sennetsu fever (11), carrion's disease (9), bacillary angiomatosis (8), leukodystrophy, hypomyelinating, 4 (8), blastomycosis (7), chancroid (7), bartonellosis (5), tularemia (5), maple syrup urine disease, type ii (4), diabetes mellitus, permanent neonatal (4), leprosy (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 138.19 RPKM in Adrenal Gland
Total median expression: 2197.68 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.1058-0.243 Picture PostScript Text
3' UTR -18.60190-0.098 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR020818 - Chaperonin_Cpn10
IPR018369 - Chaprnonin_Cpn10_CS
IPR011032 - GroES-like

Pfam Domains:
PF00166 - Chaperonin 10 Kd subunit

SCOP Domains:
50129 - GroES-like

ModBase Predicted Comparative 3D Structure on P61604
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details Gene Details Gene Details
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     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding

Biological Process:
GO:0001649 osteoblast differentiation
GO:0006457 protein folding
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006986 response to unfolded protein
GO:0051085 chaperone mediated protein folding requiring cofactor

Cellular Component:
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0016020 membrane
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  BC023518 - Homo sapiens heat shock 10kDa protein 1 (chaperonin 10), mRNA (cDNA clone MGC:12734 IMAGE:4304224), complete cds.
GQ900897 - Homo sapiens clone HEL-T-9 epididymis secretory sperm binding protein mRNA, complete cds.
GQ900904 - Homo sapiens clone HEL-T-16 epididymis secretory sperm binding protein mRNA, complete cds.
U07550 - Human chaperonin 10 mRNA, complete cds.
AK312104 - Homo sapiens cDNA, FLJ92386, Homo sapiens heat shock 10kDa protein 1 (chaperonin 10) (HSPE1),mRNA.
JD369069 - Sequence 350093 from Patent EP1572962.
AB590417 - Synthetic construct DNA, clone: pFN21AE2235, Homo sapiens HSPE1 gene for heat shock 10kDa protein 1, without stop codon, in Flexi system.
CR407688 - Homo sapiens full open reading frame cDNA clone RZPDo834E0416D for gene HSPE1, heat shock 10kDa protein 1 (chaperonin 10) complete cds, without stopcodon.
DQ892960 - Synthetic construct clone IMAGE:100005590; FLH191180.01X; RZPDo839A0677D heat shock 10kDa protein 1 (chaperonin 10) (HSPE1) gene, encodes complete protein.
DQ896207 - Synthetic construct Homo sapiens clone IMAGE:100010667; FLH191176.01L; RZPDo839A0667D heat shock 10kDa protein 1 (chaperonin 10) (HSPE1) gene, encodes complete protein.
X75821 - H.sapiens mRNA for heat shock protein 10.
LF357734 - JP 2014500723-A/165237: Polycomb-Associated Non-Coding RNAs.
JD052341 - Sequence 33365 from Patent EP1572962.
MA593311 - JP 2018138019-A/165237: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: CH10_HUMAN, ENST00000233893.1, ENST00000233893.2, ENST00000233893.3, ENST00000233893.4, ENST00000233893.5, ENST00000233893.6, ENST00000233893.7, ENST00000233893.8, ENST00000233893.9, NM_002157, O95421, P61604, Q04984, Q53X54, Q9UDH0, uc317dyd.1, uc317dyd.2
UCSC ID: ENST00000233893.10_4
RefSeq Accession: NM_002157.3
Protein: P61604 (aka CH10_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.