Human Gene HSPA8 (ENST00000534624.6_7) from GENCODE V47lift37
  Description: heat shock protein family A (Hsp70) member 8, transcript variant 1 (from RefSeq NM_006597.6)
Gencode Transcript: ENST00000534624.6_7
Gencode Gene: ENSG00000109971.14_18
Transcript (Including UTRs)
   Position: hg19 chr11:122,928,197-122,932,844 Size: 4,648 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr11:122,928,442-122,932,032 Size: 3,591 Coding Exon Count: 8 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr11:122,928,197-122,932,844)mRNA (may differ from genome)Protein (646 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HSPA8
Diseases sorted by gene-association score: auditory system disease (11), brain ischemia (11), oral lichen planus (7), sleeping sickness (5), dowling-degos disease (4), leber congenital amaurosis (2), cystic fibrosis (2), parkinson disease, late-onset (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 380.20 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 8982.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -17.6078-0.226 Picture PostScript Text
3' UTR -59.30245-0.242 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  JD304292 - Sequence 285316 from Patent EP1572962.
AF217511 - Homo sapiens uncharacterized bone marrow protein BM034 mRNA, complete cds.
BC007276 - Homo sapiens heat shock 70kDa protein 8, mRNA (cDNA clone IMAGE:3162067), partial cds.
AB073886 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla02874, full insert sequence.
BC016660 - Homo sapiens heat shock 70kDa protein 8, mRNA (cDNA clone MGC:9495 IMAGE:3923981), complete cds.
EU668349 - Homo sapiens epididymis luminal protein 33 (HEL-33) mRNA, complete cds.
AK222628 - Homo sapiens mRNA for heat shock 70kDa protein 8 isoform 2 variant, clone: CBL04813.
AK096100 - Homo sapiens cDNA FLJ38781 fis, clone LIVER2000216, highly similar to HEAT SHOCK COGNATE 71 KDA PROTEIN.
FJ224294 - Homo sapiens epididymis secretory sperm binding protein Li 72p (HEL-S-72p) mRNA, complete cds.
GQ891398 - Homo sapiens clone HEL-S-92 epididymis secretory sperm binding protein mRNA, complete cds.
JD304291 - Sequence 285315 from Patent EP1572962.
AK129885 - Homo sapiens cDNA FLJ26375 fis, clone HRT06292, highly similar to Heat shock cognate 71 kDa protein.
AK000571 - Homo sapiens cDNA FLJ20564 fis, clone KAT12033.
BC008907 - Homo sapiens heat shock 70kDa protein 8, mRNA (cDNA clone IMAGE:3836086), partial cds.
BC015699 - Homo sapiens, clone IMAGE:3906958, mRNA, partial cds.
BC016179 - Homo sapiens heat shock 70kDa protein 8, mRNA (cDNA clone MGC:17984 IMAGE:3920744), complete cds.
BC112920 - Homo sapiens heat shock 70kDa protein 8, mRNA (cDNA clone IMAGE:7484542), **** WARNING: chimeric clone ****.
BC042163 - Homo sapiens heat shock 70kDa protein 8, mRNA (cDNA clone IMAGE:4862437), **** WARNING: chimeric clone ****.
BC019816 - Homo sapiens heat shock 70kDa protein 8, mRNA (cDNA clone MGC:29929 IMAGE:2899894), complete cds.
AK292067 - Homo sapiens cDNA FLJ77848 complete cds.
AF352832 - Homo sapiens constitutive heat shock protein 70 (HSC70) mRNA, complete cds.
JD288827 - Sequence 269851 from Patent EP1572962.
AK303935 - Homo sapiens cDNA FLJ55485 complete cds, highly similar to Heat shock cognate 71 kDa protein.
AK222785 - Homo sapiens mRNA for heat shock 70kDa protein 8 isoform 1 variant, clone: HEP02822.
AB034951 - Homo sapiens HSC54 mRNA for heat shock cognate protein 54, complete cds.
KJ905785 - Synthetic construct Homo sapiens clone ccsbBroadEn_15455 HSPA8 gene, encodes complete protein.
GQ891324 - Homo sapiens clone HEL-S-55b epididymis secretory sperm binding protein mRNA, complete cds.
KJ901499 - Synthetic construct Homo sapiens clone ccsbBroadEn_10893 HSPA8 gene, encodes complete protein.
KJ897016 - Synthetic construct Homo sapiens clone ccsbBroadEn_06410 HSPA8 gene, encodes complete protein.
DQ891145 - Synthetic construct clone IMAGE:100003775; FLH169720.01X; RZPDo839F0596D heat shock 70kDa protein 8 (HSPA8) gene, encodes complete protein.
DQ894325 - Synthetic construct Homo sapiens clone IMAGE:100008785; FLH169716.01L; RZPDo839F0595D heat shock 70kDa protein 8 (HSPA8) gene, encodes complete protein.
AB527307 - Synthetic construct DNA, clone: pF1KB5306, Homo sapiens HSPA8 gene for heat shock 70kDa protein 8, without stop codon, in Flexi system.
JD143036 - Sequence 124060 from Patent EP1572962.
JD492279 - Sequence 473303 from Patent EP1572962.
JD546621 - Sequence 527645 from Patent EP1572962.
AK310467 - Homo sapiens cDNA, FLJ17509.
AK300404 - Homo sapiens cDNA FLJ59163 complete cds, highly similar to Heat shock cognate 71 kDa protein.
DL490036 - Novel nucleic acids.
JD328913 - Sequence 309937 from Patent EP1572962.
DQ595374 - Homo sapiens piRNA piR-61486, complete sequence.
JD020302 - Sequence 1326 from Patent EP1572962.
DQ591926 - Homo sapiens piRNA piR-59038, complete sequence.
JD369809 - Sequence 350833 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000534624.1, ENST00000534624.2, ENST00000534624.3, ENST00000534624.4, ENST00000534624.5, hCG_2032950 , HEL-33 , HEL-S-72p , HSPA8 , NM_006597, uc324ncy.1, uc324ncy.2, V9HW22, V9HW22_HUMAN
UCSC ID: ENST00000534624.6_7
RefSeq Accession: NM_006597.6

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.