ID:HS71L_HUMAN DESCRIPTION: RecName: Full=Heat shock 70 kDa protein 1-like; Short=Heat shock 70 kDa protein 1L; AltName: Full=Heat shock 70 kDa protein 1-Hom; Short=HSP70-Hom; FUNCTION: In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage (By similarity). TISSUE SPECIFICITY: Expressed in spermatids. INDUCTION: Not induced by heat shock. SIMILARITY: Belongs to the heat shock protein 70 family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hspa1l/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P34931
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006986 response to unfolded protein GO:0007339 binding of sperm to zona pellucida GO:0042026 protein refolding GO:1900034 regulation of cellular response to heat GO:1903955 positive regulation of protein targeting to mitochondrion
JD549961 - Sequence 530985 from Patent EP1572962. JD378556 - Sequence 359580 from Patent EP1572962. JD483970 - Sequence 464994 from Patent EP1572962. JD490661 - Sequence 471685 from Patent EP1572962. BC034483 - Homo sapiens heat shock 70kDa protein 1-like, mRNA (cDNA clone MGC:26463 IMAGE:4824979), complete cds. AK223386 - Homo sapiens mRNA for heat shock 70kDa protein 1-like variant, clone: FCC106F11. D85730 - Homo sapiens HSPA1L mRNA for heat shock protein 70 testis variant, complete cds. JD290587 - Sequence 271611 from Patent EP1572962. AK295416 - Homo sapiens cDNA FLJ56386 complete cds, highly similar to Heat shock 70 kDa protein 1L. AK302179 - Homo sapiens cDNA FLJ56517 complete cds, highly similar to Heat shock 70 kDa protein 1L. GQ891337 - Homo sapiens clone HEL-S-108d epididymis secretory sperm binding protein mRNA, complete cds. AK315227 - Homo sapiens cDNA, FLJ96225, highly similar to Homo sapiens heat shock 70kDa protein 1-like (HSPA1L), mRNA. KJ897013 - Synthetic construct Homo sapiens clone ccsbBroadEn_06407 HSPA1L gene, encodes complete protein. AM392545 - Synthetic construct Homo sapiens clone IMAGE:100002617 for hypothetical protein (HSPA1L gene). AM392811 - Synthetic construct Homo sapiens clone IMAGE:100002885 for hypothetical protein (HSPA1L gene). AM393413 - Synthetic construct Homo sapiens clone IMAGE:100002886 for hypothetical protein (HSPA1L gene). AB587491 - Synthetic construct DNA, clone: pF1KB8708, Homo sapiens HSPA1L gene for heat shock 70kDa protein 1-like, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P34931 (Reactome details) participates in the following event(s):
R-HSA-5251942 Hikeshi binds HSP70s:ATP R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP R-HSA-3371503 STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein R-HSA-3371422 ATP hydrolysis by HSP70 R-HSA-3371590 HSP70 binds to HSP40:nascent protein R-HSA-5618098 p23 (PTGES3) binds HSP90:ATP:FKBP5:nascent protein R-HSA-5618110 p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm R-HSA-5082384 HSP70:DNAJB1 binds HSF1 R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm R-HSA-5618085 FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein R-HSA-5618105 FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein R-HSA-5618107 ATP binding to HSP90 triggers conformation change R-HSA-5082369 Acetylated HSF1 dissociates from DNA R-HSA-3371518 SIRT1 binds to HSF1 R-HSA-3371554 HSF1 acetylation at Lys80 R-HSA-3371467 SIRT1 deacetylates HSF1 R-HSA-3371571 HSF1-dependent transactivation R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-3371556 Cellular response to heat stress R-HSA-3371568 Attenuation phase R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
