ID:HXB3_HUMAN DESCRIPTION: RecName: Full=Homeobox protein Hox-B3; AltName: Full=Homeobox protein Hox-2.7; AltName: Full=Homeobox protein Hox-2G; FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9 weeks from conception. SIMILARITY: Belongs to the Antp homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P14651
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0043565 sequence-specific DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001525 angiogenesis GO:0002244 hematopoietic progenitor cell differentiation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007275 multicellular organism development GO:0009952 anterior/posterior pattern specification GO:0021546 rhombomere development GO:0021615 glossopharyngeal nerve morphogenesis GO:0030878 thyroid gland development GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048704 embryonic skeletal system morphogenesis GO:0050767 regulation of neurogenesis GO:0051216 cartilage development GO:0060216 definitive hemopoiesis GO:0060324 face development
AK316245 - Homo sapiens cDNA, FLJ79144 complete cds, highly similar to Homeobox protein Hox-B3. AK291182 - Homo sapiens cDNA FLJ78523 complete cds, highly similar to Homo sapiens homeo box B3 (HOXB3), mRNA. AK315102 - Homo sapiens cDNA, FLJ96060, highly similar to Homo sapiens homeo box B3 (HOXB3), mRNA. AK027609 - Homo sapiens cDNA FLJ14703 fis, clone NT2RP3000512, highly similar to Homeobox protein Hox-B3. JD075546 - Sequence 56570 from Patent EP1572962. JD063618 - Sequence 44642 from Patent EP1572962. U59298 - Human hox homeobox transcription factor (HOXB3) mRNA, complete cds. JD445021 - Sequence 426045 from Patent EP1572962. JD507480 - Sequence 488504 from Patent EP1572962. JD041554 - Sequence 22578 from Patent EP1572962. X16667 - Human HOX2G mRNA from the Hox2 locus. JD386132 - Sequence 367156 from Patent EP1572962. JD151386 - Sequence 132410 from Patent EP1572962. JD260009 - Sequence 241033 from Patent EP1572962. JD322784 - Sequence 303808 from Patent EP1572962. AK309721 - Homo sapiens cDNA, FLJ99762. AK299226 - Homo sapiens cDNA FLJ51054 complete cds, highly similar to Homeobox protein Hox-B3. AK299265 - Homo sapiens cDNA FLJ50179 complete cds, highly similar to Homeobox protein Hox-B3. JD484042 - Sequence 465066 from Patent EP1572962. JD482366 - Sequence 463390 from Patent EP1572962. BC172242 - Synthetic construct Homo sapiens clone IMAGE:100068936, MGC:198947 homeobox B3 (HOXB3) mRNA, encodes complete protein. BC172550 - Synthetic construct Homo sapiens clone IMAGE:100069244, MGC:199255 homeobox B3 (HOXB3) mRNA, encodes complete protein. AB463750 - Synthetic construct DNA, clone: pF1KB9726, Homo sapiens HOXB3 gene for homeobox B3, without stop codon, in Flexi system. DQ597799 - Homo sapiens piRNA piR-35865, complete sequence. JD234010 - Sequence 215034 from Patent EP1572962. JD493953 - Sequence 474977 from Patent EP1572962. JD548350 - Sequence 529374 from Patent EP1572962. JD257144 - Sequence 238168 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P14651 (Reactome details) participates in the following event(s):
R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis R-HSA-5619507 Activation of HOX genes during differentiation R-HSA-1266738 Developmental Biology
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
