ID:HMGN1_HUMAN DESCRIPTION: RecName: Full=Non-histone chromosomal protein HMG-14; AltName: Full=High mobility group nucleosome-binding domain-containing protein 1; FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus. PTM: Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization. RNA EDITING: Modified_positions=Not_applicable; Note=Partially edited. A new initiator methionine may be created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 45 amino acids. The existence of the RNA edited version is supported by direct protein sequencing by MS/MS of the following peptides specific to that version: 23-31 and 40-48. The RNA edited version is called ET-HMGN1. MASS SPECTROMETRY: Mass=10527.8; Mass_error=0.7; Method=Electrospray; Range=2-100; Source=PubMed:10739259; MASS SPECTROMETRY: Mass=10608; Method=Electrospray; Range=2-100; Source=PubMed:10739259; MASS SPECTROMETRY: Mass=10688; Mass_error=1.3; Method=Electrospray; Range=2-100; Source=PubMed:10739259; MASS SPECTROMETRY: Mass=10768; Method=Electrospray; Range=2-100; Source=PubMed:10739259; SIMILARITY: Belongs to the HMGN family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P05114
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC107741 - Homo sapiens high-mobility group nucleosome binding domain 1, mRNA (cDNA clone MGC:104230 IMAGE:6495117), complete cds. BC023984 - Homo sapiens high-mobility group nucleosome binding domain 1, mRNA (cDNA clone MGC:23740 IMAGE:4104558), complete cds. BC070154 - Homo sapiens high-mobility group nucleosome binding domain 1, mRNA (cDNA clone MGC:88134 IMAGE:6495327), complete cds. BC000075 - Homo sapiens high-mobility group nucleosome binding domain 1, mRNA (cDNA clone MGC:1997 IMAGE:3510312), complete cds. AK130775 - Homo sapiens cDNA FLJ27265 fis, clone TMS00186. AK056033 - Homo sapiens cDNA FLJ31471 fis, clone NT2NE2001435. AB209245 - Homo sapiens mRNA for Hypothetical protein FLJ31471 variant protein. BC071643 - Homo sapiens high-mobility group nucleosome binding domain 1, mRNA (cDNA clone MGC:87800 IMAGE:5549431), complete cds. BC072672 - Homo sapiens high-mobility group nucleosome binding domain 1, mRNA (cDNA clone MGC:87801 IMAGE:6166317), complete cds. BC106080 - Homo sapiens high-mobility group nucleosome binding domain 1, mRNA (cDNA clone MGC:117425 IMAGE:3855939), complete cds. J02621 - Human non-histone chromosomal protein HMG-14 mRNA, complete cds. JD326212 - Sequence 307236 from Patent EP1572962. JD224900 - Sequence 205924 from Patent EP1572962. JD552809 - Sequence 533833 from Patent EP1572962. BC070153 - Homo sapiens high-mobility group nucleosome binding domain 1, mRNA (cDNA clone MGC:88133 IMAGE:6450636), complete cds. JD481535 - Sequence 462559 from Patent EP1572962. JD566363 - Sequence 547387 from Patent EP1572962. JD545886 - Sequence 526910 from Patent EP1572962. JD231743 - Sequence 212767 from Patent EP1572962. AK315410 - Homo sapiens cDNA, FLJ96459. BT007337 - Homo sapiens high-mobility group nucleosome binding domain 1 mRNA, complete cds. KJ891359 - Synthetic construct Homo sapiens clone ccsbBroadEn_00753 HMGN1 gene, encodes complete protein. DQ891741 - Synthetic construct clone IMAGE:100004371; FLH180249.01X; RZPDo839A02134D high-mobility group nucleosome binding domain 1 (HMGN1) gene, encodes complete protein. DQ894919 - Synthetic construct Homo sapiens clone IMAGE:100009379; FLH180245.01L; RZPDo839A02133D high-mobility group nucleosome binding domain 1 (HMGN1) gene, encodes complete protein. AB590110 - Synthetic construct DNA, clone: pFN21AE1455, Homo sapiens HMGN1 gene for high-mobility group nucleosome binding domain 1, without stop codon, in Flexi system. JD436997 - Sequence 418021 from Patent EP1572962. JD460539 - Sequence 441563 from Patent EP1572962. JD142281 - Sequence 123305 from Patent EP1572962. JD480659 - Sequence 461683 from Patent EP1572962. JD122416 - Sequence 103440 from Patent EP1572962. JD217673 - Sequence 198697 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_p38mapkPathway - p38 MAPK Signaling Pathway
Reactome (by CSHL, EBI, and GO)
Protein P05114 (Reactome details) participates in the following event(s):
R-HSA-6782004 Assembly of the pre-incision complex in TC-NER R-HSA-6782069 UVSSA:USP7 deubiquitinates ERCC6 R-HSA-6782131 RNA Pol II backtracking in TC-NER R-HSA-6782138 ERCC5 and RPA bind TC-NER site R-HSA-6782211 DNA polymerases delta, epsilon or kappa bind the TC-NER site R-HSA-6782204 5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER R-HSA-6782224 3' incision by ERCC5 (XPG) in TC-NER R-HSA-6782227 Ligation of newly synthesized repair patch to incised DNA in TC-NER R-HSA-6782208 Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER R-HSA-6782141 Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER R-HSA-6781823 Formation of TC-NER Pre-Incision Complex R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) R-HSA-6782135 Dual incision in TC-NER R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER R-HSA-5696398 Nucleotide Excision Repair R-HSA-73894 DNA Repair
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
