ID:HXK1_HUMAN DESCRIPTION: RecName: Full=Hexokinase-1; EC=2.7.1.1; AltName: Full=Brain form hexokinase; AltName: Full=Hexokinase type I; Short=HK I; CATALYTIC ACTIVITY: ATP + D-hexose = ADP + D-hexose 6-phosphate. ENZYME REGULATION: Hexokinase is an allosteric enzyme inhibited by its product Glc-6-P. PATHWAY: Carbohydrate metabolism; hexose metabolism. SUBUNIT: Monomer. INTERACTION: P21796:VDAC1; NbExp=2; IntAct=EBI-713162, EBI-354158; SUBCELLULAR LOCATION: Mitochondrion outer membrane. Note=Its hydrophobic N-terminal sequence may be involved in membrane binding. TISSUE SPECIFICITY: Isoform 2 is erythrocyte specific. Isoform 3 and isoform 4 are testis-specific. DOMAIN: The N- and C-terminal halves of this hexokinase show extensive sequence similarity to each other. The catalytic activity is associated with the C-terminus while regulatory function is associated with the N-terminus. Each domain can bind a single glucose and Gluc-6-P molecule. DISEASE: Defects in HK1 are the cause of hexokinase deficiency (HK deficiency) [MIM:235700]. HK deficiency is a rare autosomal recessive disease with nonspherocytic hemolytic anemia as the predominant clinical feature. MISCELLANEOUS: In vertebrates there are four major glucose- phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase). SIMILARITY: Belongs to the hexokinase family. WEB RESOURCE: Name=Wikipedia; Note=Hexokinase entry; URL="http://en.wikipedia.org/wiki/Hexokinase";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P19367
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001678 cellular glucose homeostasis GO:0005975 carbohydrate metabolic process GO:0006096 glycolytic process GO:0008152 metabolic process GO:0016310 phosphorylation GO:0019318 hexose metabolic process GO:0046835 carbohydrate phosphorylation GO:0051156 glucose 6-phosphate metabolic process GO:0061621 canonical glycolysis GO:0072655 establishment of protein localization to mitochondrion GO:0072656 maintenance of protein location in mitochondrion
U38226 - Human testis-specific hexokinase 1 (hHK1-ta) mRNA, partial cds. U38227 - Human testis-specific hexokinase 1 (hHK1-tb) mRNA, partial cds. U38228 - Human testis-specific hexokinase 1 (hHK1-tc) mRNA, partial cds. AK128226 - Homo sapiens cDNA FLJ46359 fis, clone TESTI4049786, highly similar to Hexokinase-1 (EC 2.7.1.1). AF073786 - Homo sapiens testis-specific hexokinase 1 mRNA, partial cds. JD202583 - Sequence 183607 from Patent EP1572962. JD066447 - Sequence 47471 from Patent EP1572962. JD292282 - Sequence 273306 from Patent EP1572962. KJ896973 - Synthetic construct Homo sapiens clone ccsbBroadEn_06367 HK1 gene, encodes complete protein. KJ905209 - Synthetic construct Homo sapiens clone ccsbBroadEn_14665 HK1 gene, encodes complete protein. KR709982 - Synthetic construct Homo sapiens clone CCSBHm_00008709 HK1 (HK1) mRNA, encodes complete protein. KR709983 - Synthetic construct Homo sapiens clone CCSBHm_00008710 HK1 (HK1) mRNA, encodes complete protein. AK292012 - Homo sapiens cDNA FLJ78173 complete cds, highly similar to Homo sapiens hexokinase 1 (HK1) mRNA. AK294428 - Homo sapiens cDNA FLJ56506 complete cds, highly similar to Hexokinase-1 (EC 2.7.1.1). AB209526 - Homo sapiens mRNA for hexokinase 1 isoform HKI variant protein. M75126 - Homo sapiens hexokinase 1 (HK1) mRNA, complete cds. AK309904 - Homo sapiens cDNA, FLJ99945. BC008730 - Homo sapiens hexokinase 1, mRNA (cDNA clone MGC:1724 IMAGE:3163058), complete cds. DQ896762 - Synthetic construct Homo sapiens clone IMAGE:100011222; FLH195902.01L; RZPDo839H07151D hexokinase 1 (HK1) gene, encodes complete protein. DQ893281 - Synthetic construct clone IMAGE:100005911; FLH195906.01X; RZPDo839H07152D hexokinase 1 (HK1) gene, encodes complete protein. CU679065 - Synthetic construct Homo sapiens gateway clone IMAGE:100017842 5' read HK1 mRNA. AB384968 - Synthetic construct DNA, clone: pF1KB4596, Homo sapiens HK1 gene for hexokinase-1, complete cds, without stop codon, in Flexi system. AK091267 - Homo sapiens cDNA FLJ33948 fis, clone CTONG2018379, highly similar to Hexokinase-1 (EC 2.7.1.1). X66957 - H. sapiens hexokinase I (MK-16). JD068440 - Sequence 49464 from Patent EP1572962. JD337262 - Sequence 318286 from Patent EP1572962. JD206854 - Sequence 187878 from Patent EP1572962. JD132619 - Sequence 113643 from Patent EP1572962. JD164762 - Sequence 145786 from Patent EP1572962. JD524453 - Sequence 505477 from Patent EP1572962. JD226422 - Sequence 207446 from Patent EP1572962. JD232844 - Sequence 213868 from Patent EP1572962. JD530653 - Sequence 511677 from Patent EP1572962. JD425703 - Sequence 406727 from Patent EP1572962. JD460008 - Sequence 441032 from Patent EP1572962. JD132117 - Sequence 113141 from Patent EP1572962. JD103069 - Sequence 84093 from Patent EP1572962. JD188214 - Sequence 169238 from Patent EP1572962. JD356992 - Sequence 338016 from Patent EP1572962. JD551990 - Sequence 533014 from Patent EP1572962. JD283678 - Sequence 264702 from Patent EP1572962. JD306218 - Sequence 287242 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-5514 - UDP-N-acetyl-D-galactosamine biosynthesis II PWY-5661-1 - GDP-glucose biosynthesis II PWY-5941 - glycogenolysis PWY0-1182 - trehalose degradation PWY66-400 - glycolysis PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle UDPNACETYLGALSYN-PWY - UDP-N-acetyl-D-glucosamine biosynthesis II
Reactome (by CSHL, EBI, and GO)
Protein P19367 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
