Human Gene HGF (ENST00000222390.11_15) from GENCODE V47lift37
  Description: hepatocyte growth factor, transcript variant 1 (from RefSeq NM_000601.6)
Gencode Transcript: ENST00000222390.11_15
Gencode Gene: ENSG00000019991.18_18
Transcript (Including UTRs)
   Position: hg19 chr7:81,328,326-81,399,363 Size: 71,038 Total Exon Count: 18 Strand: -
Coding Region
   Position: hg19 chr7:81,331,897-81,399,287 Size: 67,391 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesGeneReviewsModel Information
Methods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr7:81,328,326-81,399,363)mRNA (may differ from genome)Protein (728 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: HGF_HUMAN
DESCRIPTION: RecName: Full=Hepatocyte growth factor; AltName: Full=Hepatopoietin-A; AltName: Full=Scatter factor; Short=SF; Contains: RecName: Full=Hepatocyte growth factor alpha chain; Contains: RecName: Full=Hepatocyte growth factor beta chain; Flags: Precursor;
FUNCTION: HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. It has no detectable protease activity. Activating ligand for the receptor tyrosine kinase MET by binding and promoting its dimerization.
SUBUNIT: Dimer of an alpha chain and a beta chain linked by a disulfide bond.
INTERACTION: P08581:MET; NbExp=2; IntAct=EBI-1039104, EBI-1039152; P16056:Met (xeno); NbExp=2; IntAct=EBI-1039104, EBI-1798780;
DISEASE: Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
SIMILARITY: Belongs to the peptidase S1 family. Plasminogen subfamily.
SIMILARITY: Contains 4 kringle domains.
SIMILARITY: Contains 1 PAN domain.
SIMILARITY: Contains 1 peptidase S1 domain.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/hgf/";
WEB RESOURCE: Name=Wikipedia; Note=Hepatocyte growth factor entry; URL="http://en.wikipedia.org/wiki/Hepatocyte_growth_factor";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: HGF
Diseases sorted by gene-association score: deafness, autosomal recessive 39* (935), dfnb39 nonsyndromic hearing loss and deafness* (100), autosomal recessive non-syndromic sensorineural deafness type dfnb* (46), acute kidney failure (16), acute liver failure (14), wrinkles (12), limb ischemia (12), liver cirrhosis (11), liver disease (11), deafness, autosomal recessive 97 (11), acute kidney tubular necrosis (11), critical limb ischemia (11), large cell medulloblastoma (10), doxorubicin induced cardiomyopathy (10), familial progressive hyperpigmentation (10), biliary atresia (9), microvascular complications of diabetes 1 (9), short bowel syndrome (9), vitreoretinopathy, neovascular inflammatory (8), hepatoblastoma (8), arteriosclerosis obliterans (8), burns (8), chronic myocardial ischemia (8), diffuse meningeal melanocytosis (7), endometrial squamous cell carcinoma (7), dry eye syndrome (6), gastric ulcer (6), arteriosclerosis (6), familial renal papillary carcinoma (6), renal fibrosis (6), chronic leukemia (6), obstructive jaundice (5), bladder squamous cell carcinoma (5), spindle cell synovial sarcoma (5), spinal chordoma (5), lung cancer (5), renal cell carcinoma (4), hepatocellular carcinoma (4), pulmonary fibrosis (4), stomach cancer (4), central nervous system melanocytic neoplasm (4), pancreatic cancer (3), breast cancer (3), endometrial cancer (2), medulloblastoma (2), colorectal cancer (1), pulmonary fibrosis, idiopathic (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.79 RPKM in Lung
Total median expression: 62.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -14.5076-0.191 Picture PostScript Text
3' UTR -758.903571-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024174 - HGF_MST1
IPR000001 - Kringle
IPR013806 - Kringle-like
IPR018056 - Kringle_CS
IPR003014 - PAN-1_domain
IPR003609 - Pan_app
IPR009003 - Pept_cys/ser_Trypsin-like
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A

Pfam Domains:
PF00024 - PAN domain
PF00051 - Kringle domain
PF00089 - Trypsin

SCOP Domains:
50494 - Trypsin-like serine proteases
57414 - Hairpin loop containing domain-like
57440 - Kringle-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1BHT - X-ray MuPIT 1GMN - X-ray MuPIT 1GMO - X-ray MuPIT 1GP9 - X-ray MuPIT 1NK1 - X-ray MuPIT 1SHY - X-ray MuPIT 1SI5 - X-ray MuPIT 2HGF - NMR MuPIT 2QJ2 - X-ray MuPIT 3HMS - X-ray MuPIT 3HMT - X-ray MuPIT 3HN4 - X-ray MuPIT 3MKP - X-ray MuPIT 3SP8 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P14210
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004713 protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0042056 chemoattractant activity
GO:0042802 identical protein binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0046982 protein heterodimerization activity
GO:0004252 serine-type endopeptidase activity

Biological Process:
GO:0000165 MAPK cascade
GO:0000187 activation of MAPK activity
GO:0000278 mitotic cell cycle
GO:0000902 cell morphogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001889 liver development
GO:0002576 platelet degranulation
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0010469 regulation of receptor activity
GO:0010507 negative regulation of autophagy
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030212 hyaluronan metabolic process
GO:0030335 positive regulation of cell migration
GO:0031100 animal organ regeneration
GO:0031643 positive regulation of myelination
GO:0032715 negative regulation of interleukin-6 production
GO:0032733 positive regulation of interleukin-10 production
GO:0033137 negative regulation of peptidyl-serine phosphorylation
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045669 positive regulation of osteoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046854 phosphatidylinositol phosphorylation
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0050728 negative regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050918 positive chemotaxis
GO:0051450 myoblast proliferation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060326 cell chemotaxis
GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0070572 positive regulation of neuron projection regeneration
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:1900744 regulation of p38MAPK cascade
GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death
GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1902947 regulation of tau-protein kinase activity
GO:2000573 positive regulation of DNA biosynthetic process
GO:0006508 proteolysis

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031093 platelet alpha granule lumen


-  Descriptions from all associated GenBank mRNAs
  X16323 - Human mRNA for hepatocyte growth factor (HGF).
AK291674 - Homo sapiens cDNA FLJ76306 complete cds, highly similar to Homo sapiens hepatocyte growth factor (hepapoietin A; scatterfactor) (HGF), mRNA.
M73240 - Human (clone SF2) hepatacyte growth factor (HGF) mRNA, complete cds.
M73239 - Human (clone SF1) hepatocyte growth factor (HGF) mRNA, complete cds.
M29145 - Human hepatocyte growth factor (hHGF) mRNA, complete cds.
E03083 - cDNA encoding human hepatocyte growth factor,h-HGF.
M60718 - Human hepatocyte growth factor mRNA, complete cds.
BC130284 - Homo sapiens hepatocyte growth factor (hepapoietin A; scatter factor), mRNA (cDNA clone MGC:163156 IMAGE:40146315), complete cds.
BC130286 - Homo sapiens hepatocyte growth factor (hepapoietin A; scatter factor), mRNA (cDNA clone MGC:163158 IMAGE:40146317), complete cds.
E02804 - cDNA sequence coding for human hepatic growth factor.
E03331 - Human HGF gene.
E03436 - cDNA sequence encoding hHGF.
E05302 - DNA encoding antagonist to human hepatic cell growth factor.
M55379 - Human mitogen mRNA sequence.
E05007 - HLC3 cDNA sequence coding for human hepatopareuchymal cell growth factor(HGF).
E05008 - HLC2 cDNA sequence coding for human hepatoparenchymal cell growth factor(HGF).
AK313694 - Homo sapiens cDNA, FLJ94284.
HQ258511 - Synthetic construct Homo sapiens clone IMAGE:100072940 hepatocyte growth factor (hepapoietin A (HGF) gene, encodes complete protein.
E06576 - cDNA encoding human growth factor for endothelial cell.
E08541 - DNA encoding Hepatocyte Growth Factor.
E09626 - DNA encoding human HGF.
E02920 - DNA sequence of HAC 19 cDNA coding for human HGF.
L02931 - Human hepatocyte growth factor heavy chain (HGF) gene mRNA, complete cds.
M77227 - H.sapiens competitive HGF antagonist mRNA, complete cds.
X57574 - Human mRNA for hepatocyte growth factor.
BC022308 - Homo sapiens hepatocyte growth factor (hepapoietin A; scatter factor), mRNA (cDNA clone IMAGE:4769056), complete cds.
KJ905771 - Synthetic construct Homo sapiens clone ccsbBroadEn_15441 HGF gene, encodes complete protein.
CU692548 - Synthetic construct Homo sapiens gateway clone IMAGE:100022173 5' read HGF mRNA.
U46010 - Human HGF agonist/antagonist mRNA, complete cds.
BC063485 - Homo sapiens hepatocyte growth factor (hepapoietin A; scatter factor), mRNA (cDNA clone IMAGE:5241571), complete cds.
AB208900 - Homo sapiens mRNA for hepatocyte growth factor isoform 1 preproprotein variant protein.
BC105797 - Homo sapiens hepatocyte growth factor (hepapoietin A; scatter factor), mRNA (cDNA clone IMAGE:6559498), complete cds.
CU687746 - Synthetic construct Homo sapiens gateway clone IMAGE:100021622 5' read HGF mRNA.
KJ896968 - Synthetic construct Homo sapiens clone ccsbBroadEn_06362 HGF gene, encodes complete protein.
AB384770 - Synthetic construct DNA, clone: pF1KB3248, Homo sapiens HGF gene for hepatocyte growth factor precursor, complete cds, without stop codon, in Flexi system.
FJ830861 - Homo sapiens hepatocyte growth factor isoform 6 (HGF) mRNA, complete cds.
FJ830862 - Homo sapiens hepatocyte growth factor isoform 6 (HGF) mRNA, complete cds.
JD120327 - Sequence 101351 from Patent EP1572962.
JD284804 - Sequence 265828 from Patent EP1572962.
JD355825 - Sequence 336849 from Patent EP1572962.
JD507150 - Sequence 488174 from Patent EP1572962.
JD296514 - Sequence 277538 from Patent EP1572962.
JD154805 - Sequence 135829 from Patent EP1572962.
JD305564 - Sequence 286588 from Patent EP1572962.
JD305078 - Sequence 286102 from Patent EP1572962.
JD086729 - Sequence 67753 from Patent EP1572962.
JD564144 - Sequence 545168 from Patent EP1572962.
JD508377 - Sequence 489401 from Patent EP1572962.
JD281719 - Sequence 262743 from Patent EP1572962.
JD162265 - Sequence 143289 from Patent EP1572962.
E02919 - DNA sequence of HBC 25 cDNA coding for human HGF.
JD130857 - Sequence 111881 from Patent EP1572962.
JD500082 - Sequence 481106 from Patent EP1572962.
JD552782 - Sequence 533806 from Patent EP1572962.
JD162058 - Sequence 143082 from Patent EP1572962.
JD299529 - Sequence 280553 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_metPathway - Signaling of Hepatocyte Growth Factor Receptor

Reactome (by CSHL, EBI, and GO)

Protein P14210 (Reactome details) participates in the following event(s):

R-HSA-1266684 IL7 binds HGF(495-728) to form PPBSF
R-HSA-6800200 HPN heterodimer cleaves pro-HGF to form HGF dimer
R-HSA-6800299 HGFAC cleaves pro-HGF to form HGF dimer
R-HSA-6800298 HGF dimer binds MET
R-HSA-6806957 MET receptor dimerizes
R-HSA-481007 Exocytosis of platelet alpha granule contents
R-HSA-6806974 MET dimers autophosphorylate
R-HSA-6807008 PTPRJ dephosphorylates MET
R-HSA-6807027 PTPN1 and PTPN2 dephosphorylate MET
R-HSA-8851804 Activated MET recruits GRB2-1:SOS1
R-HSA-8851842 MUC20 binds MET and inhibits GRB2 binding
R-HSA-8851859 Activated MET binds RANBP9 and SOS1
R-HSA-8851866 MET binds RANBP10
R-HSA-8851888 MET binds SHC1-2
R-HSA-8851908 Activated MET binds GAB1
R-HSA-8851919 Activated MET binds GAB1 and GRB2
R-HSA-8874079 PTK2 binds activated MET
R-HSA-8875523 MET binds TNS3
R-HSA-8875531 MET binds TNS4
R-HSA-8875816 STAT3 binds activated MET receptor
R-HSA-8875817 MET phosphorylates STAT3
R-HSA-8851890 MET phosphorylates SHC1-2
R-HSA-8851900 SHC1-2 bound to MET recruits GRB2:SOS1
R-HSA-8874078 PTK2 autophosphorylates
R-HSA-8874083 p-Y397-PTK2 binds SRC
R-HSA-8874685 CBL binds MET
R-HSA-8851827 RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1
R-HSA-8851877 RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET
R-HSA-8851933 MET phosphorylates GAB1
R-HSA-8851954 Phosphorylated GAB1 recruits PI3K to MET
R-HSA-8865994 GAB1 binds PTPN11
R-HSA-8875540 GAB1 recruits CRK,CRKL to MET
R-HSA-8874082 MET phosphorylates PTK2
R-HSA-8874080 SRC phosphorylates PTK2
R-HSA-8875451 MET phosphorylates CBL
R-HSA-8875183 CBL monoubiquitinates activated MET
R-HSA-8875482 CBL recruits CIN85:endophilin to ubiquitinated MET
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-8851899 RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET
R-HSA-8875558 RAPGEF1 binds CRK,CRKL
R-HSA-8852019 MET bound PI3K generates PIP3
R-HSA-8875490 EPS15 and HGS bind ubiquitinated MET
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-8875568 RAPGEF1 activates RAP1
R-HSA-1266695 Interleukin-7 signaling
R-HSA-6806942 MET Receptor Activation
R-HSA-6785807 Interleukin-4 and 13 signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-6806834 Signaling by MET
R-HSA-114608 Platelet degranulation
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-6807004 Negative regulation of MET activity
R-HSA-8851805 MET activates RAS signaling
R-HSA-8851907 MET activates PI3K/AKT signaling
R-HSA-8874081 MET activates PTK2 signaling
R-HSA-8875513 MET interacts with TNS proteins
R-HSA-8875791 MET activates STAT3
R-HSA-8875656 MET receptor recycling
R-HSA-76005 Response to elevated platelet cytosolic Ca2+
R-HSA-168256 Immune System
R-HSA-162582 Signal Transduction
R-HSA-8875878 MET promotes cell motility
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-8865999 MET activates PTPN11
R-HSA-8875555 MET activates RAP1 and RAC1
R-HSA-109582 Hemostasis
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5683057 MAPK family signaling cascades
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5663202 Diseases of signal transduction
R-HSA-1643685 Disease

-  Other Names for This Gene
  Alternate Gene Symbols: A1L3U6, ENST00000222390.1, ENST00000222390.10, ENST00000222390.2, ENST00000222390.3, ENST00000222390.4, ENST00000222390.5, ENST00000222390.6, ENST00000222390.7, ENST00000222390.8, ENST00000222390.9, HGF_HUMAN, HPTA, NM_000601, P14210, Q02935, Q13494, Q14519, Q3KRB2, Q8TCE2, Q9BYL9, Q9BYM0, Q9UDU6, uc317des.1, uc317des.2
UCSC ID: ENST00000222390.11_15
RefSeq Accession: NM_000601.6
Protein: P14210 (aka HGF_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene HGF:
deafness-overview (Genetic Hearing Loss Overview)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.