ID:HERC1_HUMAN DESCRIPTION: RecName: Full=Probable E3 ubiquitin-protein ligase HERC1; EC=6.3.2.-; AltName: Full=HECT domain and RCC1-like domain-containing protein 1; AltName: Full=p532; AltName: Full=p619; FUNCTION: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin- protein ligase which accepts ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with TSC2; interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin- rich surface protrusions. TISSUE SPECIFICITY: Widely expressed. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. SIMILARITY: Contains 14 RCC1 repeats. SIMILARITY: Contains 11 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15751
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
U50078 - Human guanine nucleotide exchange factor p532 mRNA, complete cds. AK226162 - Homo sapiens mRNA for guanine nucleotide exchange factor p532 variant, clone: ff11573. BC172910 - Synthetic construct Homo sapiens clone IMAGE:9094486 guanine nucleotide exchange factor p532 (HERC1) gene, partial cds. AK296690 - Homo sapiens cDNA FLJ60284 complete cds, highly similar to Homo sapiens guanine nucleotide exchange factor p532. AK310519 - Homo sapiens cDNA, FLJ17561. BC017384 - Homo sapiens cDNA clone IMAGE:4070780, **** WARNING: chimeric clone ****. AF131824 - Homo sapiens clone 25038 mRNA sequence. AK091624 - Homo sapiens cDNA FLJ34305 fis, clone FEBRA2007901, moderately similar to Human guanine nucleotide exchange factor p532 mRNA. BC040929 - Homo sapiens hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1, mRNA (cDNA clone IMAGE:4472317), partial cds. JD565864 - Sequence 546888 from Patent EP1572962. JD465167 - Sequence 446191 from Patent EP1572962. JD231119 - Sequence 212143 from Patent EP1572962. JD538272 - Sequence 519296 from Patent EP1572962. JD524456 - Sequence 505480 from Patent EP1572962. AY030081 - Homo sapiens unknown mRNA. BC172909 - Synthetic construct Homo sapiens clone IMAGE:9094485 guanine nucleotide exchange factor p532 (HERC1) gene, partial cds. JD405663 - Sequence 386687 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q15751 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
