ID:HECD1_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase HECTD1; EC=6.3.2.-; AltName: Full=E3 ligase for inhibin receptor; AltName: Full=EULIR; AltName: Full=HECT domain-containing protein 1; FUNCTION: Probable E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. May be required for development of the head mesenchyme and neural tube closure (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with IGSF1. SIMILARITY: Belongs to the UPL family. K-HECT subfamily. SIMILARITY: Contains 4 ANK repeats. SIMILARITY: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. SIMILARITY: Contains 1 MIB/HERC2 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULT8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AL110222 - Homo sapiens mRNA; cDNA DKFZp434K233 (from clone DKFZp434K233); partial cds. AK024847 - Homo sapiens cDNA: FLJ21194 fis, clone COL00179. AK125788 - Homo sapiens cDNA FLJ43800 fis, clone TESTI4000349, highly similar to E3 ubiquitin-protein ligase HECTD1. AY739714 - Homo sapiens HECTD1 mRNA, partial cds. AB032957 - Homo sapiens mRNA for KIAA1131 protein, partial cds. AY254380 - Homo sapiens E3 ligase for inhibin receptor mRNA, complete cds. BC172391 - Synthetic construct Homo sapiens clone IMAGE:100069085, MGC:199096 HECT domain containing 1 (HECTD1) mRNA, encodes complete protein. AK095634 - Homo sapiens cDNA FLJ38315 fis, clone FCBBF3023368. BC006237 - Homo sapiens HECT domain containing 1, mRNA (cDNA clone IMAGE:3952406), partial cds. BC083494 - Homo sapiens HECT domain containing 1, mRNA (cDNA clone IMAGE:4364596), partial cds. BC063686 - Homo sapiens HECT domain containing 1, mRNA (cDNA clone IMAGE:4499318), partial cds. BC072441 - Homo sapiens HECT domain containing 1, mRNA (cDNA clone IMAGE:6046592). BC011658 - Homo sapiens HECT domain containing 1, mRNA (cDNA clone IMAGE:4122368), partial cds. JD346050 - Sequence 327074 from Patent EP1572962. JD058834 - Sequence 39858 from Patent EP1572962. JD379430 - Sequence 360454 from Patent EP1572962. JD320883 - Sequence 301907 from Patent EP1572962. JD320460 - Sequence 301484 from Patent EP1572962. JD046444 - Sequence 27468 from Patent EP1572962. JD330659 - Sequence 311683 from Patent EP1572962. JD081113 - Sequence 62137 from Patent EP1572962. JD376584 - Sequence 357608 from Patent EP1572962. JD559858 - Sequence 540882 from Patent EP1572962. BC016947 - Homo sapiens, clone IMAGE:3846569, mRNA. JD201077 - Sequence 182101 from Patent EP1572962. JD537156 - Sequence 518180 from Patent EP1572962. JD442314 - Sequence 423338 from Patent EP1572962. JD430813 - Sequence 411837 from Patent EP1572962. JD234261 - Sequence 215285 from Patent EP1572962. JD554835 - Sequence 535859 from Patent EP1572962. JD391486 - Sequence 372510 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9ULT8 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
