ID:HAUS5_HUMAN DESCRIPTION: RecName: Full=HAUS augmin-like complex subunit 5; FUNCTION: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. SUBUNIT: Component of the HAUS augmin-like complex. The complex interacts with the gamma-tubulin ring complex and this interaction is required for spindle assembly. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes to interphase centrosomes and to mitotic spindle microtubules. SIMILARITY: Belongs to the HAUS5 family. SEQUENCE CAUTION: Sequence=AAH13947.2; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAA74864.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF14817 - HAUS augmin-like complex subunit 5
ModBase Predicted Comparative 3D Structure on O94927
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC064390 - Homo sapiens KIAA0841, mRNA (cDNA clone IMAGE:5745315), complete cds. BC171905 - Homo sapiens cDNA clone IMAGE:9054559. BC157882 - Homo sapiens KIAA0841, mRNA (cDNA clone MGC:189707 IMAGE:8862704), complete cds. AK307703 - Homo sapiens cDNA, FLJ97651. AB020648 - Homo sapiens KIAA0841 mRNA for KIAA0841 protein. BC013947 - Homo sapiens KIAA0841, mRNA (cDNA clone IMAGE:2987933), partial cds. AB384007 - Synthetic construct DNA, clone: pF1KSDA0841, Homo sapiens KIAA0841 gene for KIAA0841 protein, complete cds, without stop codon, in Flexi system. BC160190 - Synthetic construct Homo sapiens clone IMAGE:100064222, MGC:193305 KIAA0841 (KIAA0841) mRNA, encodes complete protein. JD099403 - Sequence 80427 from Patent EP1572962. JD099519 - Sequence 80543 from Patent EP1572962. JD068412 - Sequence 49436 from Patent EP1572962. JD112829 - Sequence 93853 from Patent EP1572962. JD054671 - Sequence 35695 from Patent EP1572962. JD558653 - Sequence 539677 from Patent EP1572962. JD203054 - Sequence 184078 from Patent EP1572962. JD453473 - Sequence 434497 from Patent EP1572962. JD533563 - Sequence 514587 from Patent EP1572962. JD066596 - Sequence 47620 from Patent EP1572962. JD225894 - Sequence 206918 from Patent EP1572962. JD315336 - Sequence 296360 from Patent EP1572962. JD220874 - Sequence 201898 from Patent EP1572962. JD432765 - Sequence 413789 from Patent EP1572962. JD113657 - Sequence 94681 from Patent EP1572962. JD358588 - Sequence 339612 from Patent EP1572962. JD291300 - Sequence 272324 from Patent EP1572962. JD428243 - Sequence 409267 from Patent EP1572962. JD428244 - Sequence 409268 from Patent EP1572962. JD428246 - Sequence 409270 from Patent EP1572962. JD428247 - Sequence 409271 from Patent EP1572962. JD550243 - Sequence 531267 from Patent EP1572962. JD550244 - Sequence 531268 from Patent EP1572962. JD550246 - Sequence 531270 from Patent EP1572962. JD234072 - Sequence 215096 from Patent EP1572962. JD234073 - Sequence 215097 from Patent EP1572962. JD234074 - Sequence 215098 from Patent EP1572962. JD337320 - Sequence 318344 from Patent EP1572962. JD207676 - Sequence 188700 from Patent EP1572962. JD356519 - Sequence 337543 from Patent EP1572962. JD285571 - Sequence 266595 from Patent EP1572962. JD506153 - Sequence 487177 from Patent EP1572962. JD106878 - Sequence 87902 from Patent EP1572962. JD133847 - Sequence 114871 from Patent EP1572962. JD158417 - Sequence 139441 from Patent EP1572962. JD148461 - Sequence 129485 from Patent EP1572962. JD207556 - Sequence 188580 from Patent EP1572962. JD295485 - Sequence 276509 from Patent EP1572962. JD066483 - Sequence 47507 from Patent EP1572962. JD255560 - Sequence 236584 from Patent EP1572962. JD412520 - Sequence 393544 from Patent EP1572962. JD510441 - Sequence 491465 from Patent EP1572962. JD297531 - Sequence 278555 from Patent EP1572962. JD448849 - Sequence 429873 from Patent EP1572962. JD430546 - Sequence 411570 from Patent EP1572962. JD262005 - Sequence 243029 from Patent EP1572962. JD255131 - Sequence 236155 from Patent EP1572962. JD270851 - Sequence 251875 from Patent EP1572962. JD191676 - Sequence 172700 from Patent EP1572962. JD137377 - Sequence 118401 from Patent EP1572962. JD233367 - Sequence 214391 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O94927 (Reactome details) participates in the following event(s):
R-HSA-380272 Plk1-mediated phosphorylation of Nlp R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome R-HSA-380294 Loss of C-Nap-1 from centrosomes R-HSA-380311 Recruitment of Plk1 to centrosomes R-HSA-380455 Recruitment of CDK11p58 to the centrosomes R-HSA-380303 Dissociation of Phospho-Nlp from the centrosome R-HSA-5626220 C2CD3 binds the mother centriole R-HSA-380508 Translocation of NuMA to the centrosomes R-HSA-2574845 AJUBA binds centrosome-associated AURKA R-HSA-8853405 TPX2 binds AURKA at centrosomes R-HSA-3000319 BORA binds PLK1 and AURKA R-HSA-2574840 AJUBA facilitates AURKA autophosphorylation R-HSA-3000310 AURKA phosphorylates PLK1 R-HSA-5626223 C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole R-HSA-5626681 Recruitment of transition zone proteins R-HSA-5626227 CP110 and CEP97 dissociate from the centriole R-HSA-380316 Association of NuMA with microtubules R-HSA-8853419 TPX2 promotes AURKA autophosphorylation R-HSA-5626228 The distal appendage proteins recruit TTBK2 R-HSA-5638009 CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body R-HSA-5626699 MARK4 binds ODF2 in the centriole R-HSA-5617816 RAB3IP stimulates nucleotide exchange on RAB8A R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-380320 Recruitment of NuMA to mitotic centrosomes R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-8854518 AURKA Activation by TPX2 R-HSA-380287 Centrosome maturation R-HSA-5617833 Cilium Assembly R-HSA-68877 Mitotic Prometaphase R-HSA-69275 G2/M Transition R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-68886 M Phase R-HSA-453274 Mitotic G2-G2/M phases R-HSA-69278 Cell Cycle (Mitotic) R-HSA-1640170 Cell Cycle
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
