Human Gene GTPBP4 (ENST00000360803.9_4) from GENCODE V47lift37

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Description: GTP binding protein 4 (from RefSeq NM_012341.3)
Gencode Transcript: ENST00000360803.9_4
Gencode Gene: ENSG00000107937.19_7
Transcript (Including UTRs)
Position: hg19 chr10:1,034,374-1,065,872 Size: 31,499 Total Exon Count: 17 Strand: +
Coding Region
Position: hg19 chr10:1,034,420-1,063,167 Size: 28,748 Coding Exon Count: 17

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:1,034,374-1,065,872)			mRNA (may differ from genome)		Protein (634 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NOG1_HUMAN DESCRIPTION: RecName: Full=Nucleolar GTP-binding protein 1; AltName: Full=Chronic renal failure gene protein; AltName: Full=GTP-binding protein NGB; FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit (By similarity). INTERACTION: P35240:NF2; NbExp=9; IntAct=EBI-1056249, EBI-1014472; SUBCELLULAR LOCATION: Nucleus, nucleolus. SIMILARITY: Belongs to the GTP1/OBG family. NOG subfamily.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GTPBP4 Diseases sorted by gene-association score: commensal bacterial infectious disease (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016572 Cyclosporine D004997 Ethinyl Estradiol D013749 Tetrachlorodibenzodioxin C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C016403 2,4-dinitrotoluene C023514 2,6-dinitrotoluene C035207 4-amino-2,6-dinitrotoluene D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D000082 Acetaminophen more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 29.62 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 386.83 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-14.50	46	-0.315	Picture	PostScript	Text
3' UTR	-843.20	2705	-0.312	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR006073 - GTP_binding_domain
IPR024926 - NOG1
IPR010674 - NOG1_Rossman_fold_dom
IPR012973 - NOG_C
IPR005225 - Small_GTP-bd_dom

Pfam Domains:
PF01926 - 50S ribosome-binding GTPase
PF02421 - Ferrous iron transport protein B
PF06858 - Nucleolar GTP-binding protein 1 (NOG1)
PF08155 - NOGCT (NUC087) domain
PF17835 - NOG1 N-terminal helical domain

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q9BZE4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003723 RNA binding GO:0003924 GTPase activity GO:0005515 protein binding GO:0005525 GTP binding Biological Process: GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0001649 osteoblast differentiation GO:0008156 negative regulation of DNA replication GO:0008285 negative regulation of cell proliferation GO:0022408 negative regulation of cell-cell adhesion GO:0030336 negative regulation of cell migration GO:0031397 negative regulation of protein ubiquitination GO:0033342 negative regulation of collagen binding GO:0042254 ribosome biogenesis GO:0050821 protein stabilization Cellular Component: GO:0005634 nucleus GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005794 Golgi apparatus GO:0005829 cytosol GO:0016020 membrane GO:0031965 nuclear membrane GO:0048471 perinuclear region of cytoplasm

Descriptions from all associated GenBank mRNAs


	AK001552 - Homo sapiens cDNA FLJ10690 fis, clone NT2RP3000350, weakly similar to PROBABLE GTP-BINDING PROTEIN HP0303. BC008683 - Homo sapiens GTP binding protein 4, mRNA (cDNA clone IMAGE:3870299), with apparent retained intron. BC021243 - Homo sapiens GTP binding protein 4, mRNA (cDNA clone IMAGE:4139481), partial cds. AF120334 - Homo sapiens GTP-binding protein NGB mRNA, complete cds. BC038975 - Homo sapiens GTP binding protein 4, mRNA (cDNA clone MGC:47676 IMAGE:5534986), complete cds. AK097093 - Homo sapiens cDNA FLJ39774 fis, clone SPLEN2001367, highly similar to Homo sapiens GTP-binding protein NGB mRNA. AK295231 - Homo sapiens cDNA FLJ53992 complete cds, highly similar to Nucleolar GTP-binding protein 1. AK001548 - Homo sapiens cDNA FLJ10686 fis, clone NT2RP3000252, highly similar to Nucleolar GTP-binding protein 1. AK222861 - Homo sapiens mRNA for G protein-binding protein CRFG variant, clone: HEP15729. KJ898511 - Synthetic construct Homo sapiens clone ccsbBroadEn_07905 GTPBP4 gene, encodes complete protein. AF325353 - Homo sapiens G protein-binding protein CRFG (CRFG) mRNA, complete cds. BC033784 - Homo sapiens GTP binding protein 4, mRNA (cDNA clone IMAGE:4474374), partial cds. AK302219 - Homo sapiens cDNA FLJ56266 complete cds, highly similar to Nucleolar GTP-binding protein 1. AK301721 - Homo sapiens cDNA FLJ55652 complete cds, highly similar to Nucleolar GTP-binding protein 1. JD224101 - Sequence 205125 from Patent EP1572962. JD225911 - Sequence 206935 from Patent EP1572962. JD440004 - Sequence 421028 from Patent EP1572962. JD502171 - Sequence 483195 from Patent EP1572962. JD379828 - Sequence 360852 from Patent EP1572962. BC040651 - Homo sapiens isopentenyl-diphosphate delta isomerase 2, mRNA (cDNA clone IMAGE:4795541). JD344157 - Sequence 325181 from Patent EP1572962. JD144744 - Sequence 125768 from Patent EP1572962. JD277887 - Sequence 258911 from Patent EP1572962. JD483532 - Sequence 464556 from Patent EP1572962. JD047887 - Sequence 28911 from Patent EP1572962. JD517865 - Sequence 498889 from Patent EP1572962. JD478257 - Sequence 459281 from Patent EP1572962. JD431721 - Sequence 412745 from Patent EP1572962. JD165861 - Sequence 146885 from Patent EP1572962. JD243119 - Sequence 224143 from Patent EP1572962. JD155955 - Sequence 136979 from Patent EP1572962. JD366772 - Sequence 347796 from Patent EP1572962. JD316908 - Sequence 297932 from Patent EP1572962. JD311000 - Sequence 292024 from Patent EP1572962. JD254007 - Sequence 235031 from Patent EP1572962. JD530192 - Sequence 511216 from Patent EP1572962. JD344611 - Sequence 325635 from Patent EP1572962. JD226116 - Sequence 207140 from Patent EP1572962. JD199156 - Sequence 180180 from Patent EP1572962. JD172912 - Sequence 153936 from Patent EP1572962. JD321886 - Sequence 302910 from Patent EP1572962. CU676059 - Synthetic construct Homo sapiens gateway clone IMAGE:100022144 3' read IDI2 mRNA. JD310733 - Sequence 291757 from Patent EP1572962. JD054862 - Sequence 35886 from Patent EP1572962. JD214960 - Sequence 195984 from Patent EP1572962. JD224996 - Sequence 206020 from Patent EP1572962. JD507507 - Sequence 488531 from Patent EP1572962. JD049604 - Sequence 30628 from Patent EP1572962. JD306070 - Sequence 287094 from Patent EP1572962. JD297277 - Sequence 278301 from Patent EP1572962. JD048082 - Sequence 29106 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: B3KMC5, B4DY13, B7Z7A3, CRFG, ENST00000360803.1, ENST00000360803.2, ENST00000360803.3, ENST00000360803.4, ENST00000360803.5, ENST00000360803.6, ENST00000360803.7, ENST00000360803.8, GTPB4_HUMAN, GTPBP4 , NM_012341, NOG1, O95446, Q5T3R8, Q9BZE4, Q9NVJ8, uc318bst.1, uc318bst.2 UCSC ID: ENST00000360803.9_4 RefSeq Accession: NM_012341.3 Protein: Q9BZE4 (aka NOG1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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