Human Gene GSTM5 (ENST00000256593.8_10) from GENCODE V47lift37

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Description: glutathione S-transferase mu 5 (from RefSeq NM_000851.4)
Gencode Transcript: ENST00000256593.8_10
Gencode Gene: ENSG00000134201.12_18
Transcript (Including UTRs)
Position: hg19 chr1:110,254,873-110,260,890 Size: 6,018 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr1:110,254,935-110,260,048 Size: 5,114 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:110,254,873-110,260,890)			mRNA (may differ from genome)		Protein (218 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q5T8R2_HUMAN DESCRIPTION: SubName: Full=Glutathione S-transferase M5; SubName: Full=Glutathione S-transferase M5, isoform CRA_b; SubName: Full=cDNA, FLJ96269, Homo sapiens glutathione S-transferase M5 (GSTM5), mRNA; SIMILARITY: Belongs to the GST superfamily. SIMILARITY: Contains 1 GST C-terminal domain. SIMILARITY: Contains 1 GST N-terminal domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D010634 Phenobarbital D013749 Tetrachlorodibenzodioxin D002994 Clofibrate D003907 Dexamethasone D004137 Dinitrochlorobenzene D004997 Ethinyl Estradiol D005978 Glutathione D011285 Pregnenolone Carbonitrile C006253 pirinixic acid D015058 1-Naphthylisothiocyanate C042630 1-chloro-2,4-dinitrobenzene-glutathione conjugate C016403 2,4-dinitrotoluene C011269 2,5-hexanedione C023514 2,6-dinitrotoluene C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone C023035 3,4,5,3',4'-pentachlorobiphenyl C521334 5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate D000082 Acetaminophen D000643 Ammonium Chloride D001149 Arsenates D001564 Benzo(a)pyrene D002083 Butylated Hydroxyanisole D002101 Cacodylic Acid D002251 Carbon Tetrachloride D004390 Chlorpyrifos D002794 Choline D002922 Ciguatoxins D003033 Coal Tar D003300 Copper D003407 Creosote D003976 Diazinon D004051 Diethylhexyl Phthalate D004052 Diethylnitrosamine C436526 EUK-189 D005015 Ethoxyquin D017313 Fenretinide D005492 Folic Acid D004397 Fonofos D019833 Genistein D008094 Lithium D008715 Methionine D009151 Mustard Gas C058346 N-(4-methoxyphenyl)retinamide C002741 N-nitrosomorpholine D009532 Nickel D017239 Paclitaxel D010278 Parathion D010695 Phlorhizin D011374 Progesterone D011794 Quercetin D012524 Sarin D013148 Spironolactone D013311 Streptozocin D013739 Testosterone D014028 Tobacco Smoke Pollution D014635 Valproic Acid D001335 Vehicle Emissions D014810 Vitamin E C019257 angelica lactone C004984 apocarotenal C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde D019207 beta Carotene C095105 bexarotene C006780 bisphenol A C053400 cafestol C030123 coumarin C007164 cumene hydroperoxide C057862 cyanoginosin LR C488369 dasatinib C014347 decitabine C121718 dicyclanil C069837 fullerene C60 C016517 indole-3-carbinol C033997 kahweol palmitate C008281 limonene C004925 methylmercuric chloride C017096 n-butoxyethanol C016104 sodium bichromate C017947 sodium arsenite C012568 terbufos D020122 tert-Butylhydroperoxide C034028 vanadyl sulfate

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 33.68 RPKM in Ovary Total median expression: 239.42 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-9.00	62	-0.145	Picture	PostScript	Text
3' UTR	-252.40	842	-0.300	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR010987 - Glutathione-S-Trfase_C-like
IPR004045 - Glutathione_S-Trfase_N
IPR017933 - Glutathione_S_Trfase/Cl_chnl_C
IPR004046 - GST_C
IPR003081 - GST_mu
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF00043 - Glutathione S-transferase, C-terminal domain
PF02798 - Glutathione S-transferase, N-terminal domain
PF14497 - Glutathione S-transferase, C-terminal domain

SCOP Domains:
47616 - GST C-terminal domain-like
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q5T8R2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
	Gene Details
	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004364 glutathione transferase activity GO:0016740 transferase activity Biological Process: GO:0008152 metabolic process Cellular Component: GO:0005829 cytosol GO:0045171 intercellular bridge

Descriptions from all associated GenBank mRNAs


	L02321 - Human glutathione S-transferase (GSTM5) mRNA, complete cds. AK127250 - Homo sapiens cDNA FLJ45317 fis, clone BRHIP3005673, highly similar to Glutathione S-transferase Mu 5 (EC 2.5.1.18). BC058881 - Homo sapiens glutathione S-transferase mu 5, mRNA (cDNA clone MGC:64821 IMAGE:6193461), complete cds. AK289673 - Homo sapiens cDNA FLJ78039 complete cds, highly similar to Homo sapiens glutathione S-transferase M5, mRNA (cDNA clone MGC:64821 IMAGE:6193461), complete cds. AK315260 - Homo sapiens cDNA, FLJ96269, Homo sapiens glutathione S-transferase M5 (GSTM5), mRNA. CU691316 - Synthetic construct Homo sapiens gateway clone IMAGE:100023189 5' read GSTM5 mRNA. HQ448167 - Synthetic construct Homo sapiens clone IMAGE:100071556; CCSB011983_03 glutathione S-transferase M5 (GSTM5) gene, encodes complete protein. KJ896940 - Synthetic construct Homo sapiens clone ccsbBroadEn_06334 GSTM5 gene, encodes complete protein. GQ891297 - Homo sapiens clone HEL-S-20a epididymis secretory sperm binding protein mRNA, complete cds. AK125820 - Homo sapiens cDNA FLJ43832 fis, clone TESTI4005543. JD411372 - Sequence 392396 from Patent EP1572962. JD075648 - Sequence 56672 from Patent EP1572962. JD556932 - Sequence 537956 from Patent EP1572962. JD325662 - Sequence 306686 from Patent EP1572962. JD371491 - Sequence 352515 from Patent EP1572962. JD226276 - Sequence 207300 from Patent EP1572962. JD411533 - Sequence 392557 from Patent EP1572962. JD494623 - Sequence 475647 from Patent EP1572962. JD429801 - Sequence 410825 from Patent EP1572962. JD553509 - Sequence 534533 from Patent EP1572962. JD464533 - Sequence 445557 from Patent EP1572962. JD045982 - Sequence 27006 from Patent EP1572962. JD038152 - Sequence 19176 from Patent EP1572962. JD479588 - Sequence 460612 from Patent EP1572962. JD199287 - Sequence 180311 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-4061 - glutathione-mediated detoxification I

Other Names for This Gene


	Alternate Gene Symbols: ENST00000256593.1, ENST00000256593.2, ENST00000256593.3, ENST00000256593.4, ENST00000256593.5, ENST00000256593.6, ENST00000256593.7, GSTM5 , hCG_40245 , NM_000851, Q5T8R2, Q5T8R2_HUMAN, uc317fvk.1, uc317fvk.2 UCSC ID: ENST00000256593.8_10 RefSeq Accession: NM_000851.4 Protein: Q5T8R2

Gene Model Information


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Methods, Credits, and Use Restrictions


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