Human Gene GSTM3 (ENST00000361066.7_7) from GENCODE V47lift37
  Description: glutathione S-transferase mu 3, transcript variant 2 (from RefSeq NR_024537.2)
Gencode Transcript: ENST00000361066.7_7
Gencode Gene: ENSG00000134202.12_10
Transcript (Including UTRs)
   Position: hg19 chr1:110,276,559-110,283,660 Size: 7,102 Total Exon Count: 9 Strand: -
Coding Region
   Position: hg19 chr1:110,279,693-110,282,909 Size: 3,217 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:110,276,559-110,283,660)mRNA (may differ from genome)Protein (225 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6FGJ9_HUMAN
DESCRIPTION: SubName: Full=GSTM3 protein; SubName: Full=Glutathione S-transferase M3 (Brain); SubName: Full=cDNA, FLJ93985, Homo sapiens glutathione S-transferase M3 (brain) (GSTM3), mRNA;
SIMILARITY: Belongs to the GST superfamily.
SIMILARITY: Contains 1 GST C-terminal domain.
SIMILARITY: Contains 1 GST N-terminal domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GSTM3
Diseases sorted by gene-association score: pharynx cancer (21), larynx cancer (16), oral cancer (7), basal cell carcinoma (6)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 137.25 RPKM in Testis
Total median expression: 801.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -130.30310-0.420 Picture PostScript Text
3' UTR -886.803134-0.283 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010987 - Glutathione-S-Trfase_C-like
IPR004045 - Glutathione_S-Trfase_N
IPR017933 - Glutathione_S_Trfase/Cl_chnl_C
IPR004046 - GST_C
IPR003081 - GST_mu
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF00043 - Glutathione S-transferase, C-terminal domain
PF02798 - Glutathione S-transferase, N-terminal domain
PF14497 - Glutathione S-transferase, C-terminal domain

SCOP Domains:
47616 - GST C-terminal domain-like
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q6FGJ9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
  Ensembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004364 glutathione transferase activity
GO:0005515 protein binding
GO:0016740 transferase activity
GO:0042803 protein homodimerization activity

Biological Process:
GO:0008152 metabolic process

Cellular Component:
GO:0005829 cytosol
GO:0035686 sperm fibrous sheath
GO:0045171 intercellular bridge


-  Descriptions from all associated GenBank mRNAs
  BC030253 - Homo sapiens glutathione S-transferase M3 (brain), mRNA (cDNA clone IMAGE:5112380).
LF385407 - JP 2014500723-A/192910: Polycomb-Associated Non-Coding RNAs.
AK131000 - Homo sapiens cDNA FLJ27490 fis, clone STM01825.
KJ905766 - Synthetic construct Homo sapiens clone ccsbBroadEn_15436 GSTM3 gene, encodes complete protein.
JD447886 - Sequence 428910 from Patent EP1572962.
JD179519 - Sequence 160543 from Patent EP1572962.
JD291617 - Sequence 272641 from Patent EP1572962.
JD431228 - Sequence 412252 from Patent EP1572962.
JD388486 - Sequence 369510 from Patent EP1572962.
JD208612 - Sequence 189636 from Patent EP1572962.
JD377666 - Sequence 358690 from Patent EP1572962.
JD158760 - Sequence 139784 from Patent EP1572962.
AK304300 - Homo sapiens cDNA FLJ51755 complete cds, highly similar to Glutathione S-transferase Mu 3 (EC 2.5.1.18).
BC000088 - Homo sapiens glutathione S-transferase mu 3 (brain), mRNA (cDNA clone MGC:3310 IMAGE:3509784), complete cds.
GQ891462 - Homo sapiens clone HEL-S-183 epididymis secretory sperm binding protein mRNA, complete cds.
J05459 - Human glutathione transferase M3 (GSTM3) mRNA, complete cds.
AB209816 - Homo sapiens mRNA for glutathione S-transferase M3 variant protein.
JD486672 - Sequence 467696 from Patent EP1572962.
JD185765 - Sequence 166789 from Patent EP1572962.
LF206297 - JP 2014500723-A/13800: Polycomb-Associated Non-Coding RNAs.
BC008790 - Homo sapiens glutathione S-transferase mu 3 (brain), mRNA (cDNA clone MGC:3704 IMAGE:3630923), complete cds.
JD373243 - Sequence 354267 from Patent EP1572962.
JD275164 - Sequence 256188 from Patent EP1572962.
JD272782 - Sequence 253806 from Patent EP1572962.
CR542108 - Homo sapiens full open reading frame cDNA clone RZPDo834G0637D for gene GSTM3, glutathione S-transferase M3 (brain); complete cds, incl. stopcodon.
KJ891309 - Synthetic construct Homo sapiens clone ccsbBroadEn_00703 GSTM3 gene, encodes complete protein.
KJ896939 - Synthetic construct Homo sapiens clone ccsbBroadEn_06333 GSTM3 gene, encodes complete protein.
AK313444 - Homo sapiens cDNA, FLJ93985, Homo sapiens glutathione S-transferase M3 (brain) (GSTM3), mRNA.
BT019945 - Homo sapiens glutathione S-transferase M3 (brain) mRNA, complete cds.
DQ891834 - Synthetic construct clone IMAGE:100004464; FLH180413.01X; RZPDo839B12134D glutathione S-transferase M3 (brain) (GSTM3) gene, encodes complete protein.
EU176637 - Synthetic construct Homo sapiens clone IMAGE:100011437; FLH180412.01L; RZPDo839A09254D glutathione S-transferase M3 (brain) (GSTM3) gene, encodes complete protein.
AB527634 - Synthetic construct DNA, clone: pF1KB5375, Homo sapiens GSTM3 gene for glutathione S-transferase mu 3, without stop codon, in Flexi system.
EF363096 - Homo sapiens clone 3B12-s044 brain type mu-glutathione S-transferase (GSTM3) mRNA, GSTM3-63C allele, complete cds.
LF211920 - JP 2014500723-A/19423: Polycomb-Associated Non-Coding RNAs.
LF353052 - JP 2014500723-A/160555: Polycomb-Associated Non-Coding RNAs.
LF353051 - JP 2014500723-A/160554: Polycomb-Associated Non-Coding RNAs.
JD192126 - Sequence 173150 from Patent EP1572962.
JD423874 - Sequence 404898 from Patent EP1572962.
JD200739 - Sequence 181763 from Patent EP1572962.
MA620984 - JP 2018138019-A/192910: Polycomb-Associated Non-Coding RNAs.
MA588629 - JP 2018138019-A/160555: Polycomb-Associated Non-Coding RNAs.
MA588628 - JP 2018138019-A/160554: Polycomb-Associated Non-Coding RNAs.
MA441874 - JP 2018138019-A/13800: Polycomb-Associated Non-Coding RNAs.
MA447497 - JP 2018138019-A/19423: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-4061 - glutathione-mediated detoxification I

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000361066.1, ENST00000361066.2, ENST00000361066.3, ENST00000361066.4, ENST00000361066.5, ENST00000361066.6, GSTM3 , hCG_40244 , NR_024537, Q6FGJ9, Q6FGJ9_HUMAN, uc318bvx.1, uc318bvx.2
UCSC ID: ENST00000361066.7_7
RefSeq Accession: NM_000849.5
Protein: Q6FGJ9

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.