Human Gene GSTA4 (ENST00000370963.9_8) from GENCODE V47lift37
Description: glutathione S-transferase alpha 4 (from RefSeq NM_001512.4)
Gencode Transcript: ENST00000370963.9_8
Gencode Gene: ENSG00000170899.11_10
Transcript (Including UTRs)
Position: hg19 chr6:52,842,751-52,860,082 Size: 17,332 Total Exon Count: 7 Strand: -
Coding Region
Position: hg19 chr6:52,843,268-52,859,041 Size: 15,774 Coding Exon Count: 6
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: GSTA4_HUMAN
DESCRIPTION: RecName: Full=Glutathione S-transferase A4; EC=2.5.1.18; AltName: Full=GST class-alpha member 4; AltName: Full=Glutathione S-transferase A4-4;
FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE).CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione.SUBUNIT: Homodimer.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver.SIMILARITY: Belongs to the GST superfamily. Alpha family.SIMILARITY: Contains 1 GST C-terminal domain.SIMILARITY: Contains 1 GST N-terminal domain.WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gsta4/";
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
C027576
4-hydroxy-2-nonenal
D010634
Phenobarbital
D004137
Dinitrochlorobenzene
C117466
8-isoprostaglandin A2
D000171
Acrolein
D016604
Aflatoxin B1
D000499
Allylamine
D001564
Benzo(a)pyrene
D002087
Butyrates
D019256
Cadmium Chloride
D002994
Clofibrate
D016572
Cyclosporine
D004317
Doxorubicin
D004976
Ethacrynic Acid
D004997
Ethinyl Estradiol
D005015
Ethoxyquin
D005978
Glutathione
D007501
Iron
D008344
Maneb
D009538
Nicotine
D010269
Paraquat
D010936
Plant Extracts
D011285
Pregnenolone Carbonitrile
D011794
Quercetin
D012838
Silymarin
D013749
Tetrachlorodibenzodioxin
C038491
allyl sulfide
C015001
arsenite
C016517
indole-3-carbinol
C023036
perfluorooctanoic acid
D020122
tert-Butylhydroperoxide
C028328
1,2-dichloro-4-nitrobenzene
C028474
1,4-bis(2-(3,5-dichloropyridyloxy))benzene
D015056
1-Methyl-3-isobutylxanthine
D015632
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C064441
13-oxo-9,11-octadecadienoic acid
C029141
2,2,5,7,8-pentamethyl-1-hydroxychroman
C031278
2-chloroethyl ethyl sulfide
C051750
2-hexenal
C060533
2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine
C030370
2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone
C018855
2-tert-butylhydroquinone
C050224
3,5,5-trimethylhexanoylferrocene
C009505
4,4'-diaminodiphenylmethane
C016583
4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone
C044135
4-hydroxy-2-decenal
C075773
4-phenylbutyric acid
D015127
9,10-Dimethyl-1,2-benzanthracene
D000111
Acetylcysteine
D000117
Acetylglucosamine
D000393
Air Pollutants
D047310
Apigenin
D001151
Arsenic
C038328
BEP protocol
D001663
Bilirubin
D002083
Butylated Hydroxyanisole
D002101
Cacodylic Acid
D002104
Cadmium
D002251
Carbon Tetrachloride
D002713
Chlorine
D020111
Chlorodiphenyl (54% Chlorine)
D002737
Chloroprene
D004390
Chlorpyrifos
D019826
Cholic Acid
D002794
Choline
D002945
Cisplatin
D003069
Coffee
D003300
Copper
D019327
Copper Sulfate
D003407
Creosote
D003474
Curcumin
D003907
Dexamethasone
D003976
Diazinon
D003993
Dibutyl Phthalate
D004041
Dietary Fats
D004051
Diethylhexyl Phthalate
D004052
Diethylnitrosamine
D004237
Diuron
D004610
Ellagic Acid
D004785
Environmental Pollutants
D000431
Ethanol
D005472
Fluorouracil
D005492
Folic Acid
D005576
Forskolin
D005839
Gentamicins
D006427
Hemin
D006861
Hydrogen Peroxide
D007854
Lead
D008054
Lipid Peroxides
D008094
Lithium
D008095
Lithocholic Acid
D008550
Melatonin
D008715
Methionine
D008767
Methylmercury Compounds
D020366
Methylmethacrylate
D052998
Microcystins
C002741
N-nitrosomorpholine
C558013
NSC 689534
C009618
O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate
D010126
Ozone
D010695
Phlorhizin
D010882
Piperonyl Butoxide
D011084
Polycyclic Hydrocarbons, Aromatic
C064116
S-(1,1,2,2-tetrafluoroethyl)cysteine
D012524
Sarin
D012643
Selenium
D053260
Soot
D013311
Streptozocin
D013629
Tamoxifen
D013755
Tetradecanoylphorbol Acetate
D014028
Tobacco Smoke Pollution
D014415
Tunicamycin
D014635
Valproic Acid
D014640
Vancomycin
D024483
Vitamin K 3
D015032
Zinc
D019287
Zinc Sulfate
C006426
aflatoxin B1-2,3-oxide
C019257
angelica lactone
C526219
apple polyphenol extract
C072553
benzyloxycarbonylleucyl-leucyl-leucine aldehyde
C053400
cafestol
C023600
chromium oxide
C074702
chromium hexavalent ion
C021977
chrysene,2-diol-3,4-epoxide-1
C018021
cobaltous chloride
C030123
coumarin
C007164
cumene hydroperoxide
C057862
cyanoginosin LR
C017160
cypermethrin
C014347
decitabine
C121718
dicyclanil
C045651
epigallocatechin gallate
C002994
ethylene dimethanesulfonate
C020326
ferric nitrilotriacetate
C050159
gamma-glutamyl-glutathione
C051890
irinotecan
C033997
kahweol palmitate
C011890
kojic acid
C008261
lead acetate
C004925
methylmercuric chloride
C078588
microcystin
C016599
mono-(2-ethylhexyl)phthalate
C406082
monomethylarsonous acid
C022838
nickel chloride
C025589
ochratoxin A
C042763
olive oil
C026209
oltipraz
C041786
palm oil
C016030
pantogab
C076994
perfluorooctane sulfonic acid
C057590
phosphatidylcholine hydroperoxide
C006253
pirinixic acid
C027373
potassium chromate(VI)
C059514
resveratrol
C089730
rosiglitazone
C541923
sandostatinLAR
C016104
sodium bichromate
C017947
sodium arsenite
C016766
sulforafan
C013698
tallow
C012589
trichostatin A
C015559
trimellitic anhydride
C025643
vinclozolin
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR010987 - Glutathione-S-Trfase_C-like
IPR004045 - Glutathione_S-Trfase_N
IPR017933 - Glutathione_S_Trfase/Cl_chnl_C
IPR003080 - GST_alpha
IPR004046 - GST_C
IPR012336 - Thioredoxin-like_fold
Pfam Domains: PF00043 - Glutathione S-transferase, C-terminal domain
PF02798 - Glutathione S-transferase, N-terminal domain
PF14497 - Glutathione S-transferase, C-terminal domain
SCOP Domains: 47616 - GST C-terminal domain-like
52833 - Thioredoxin-like
143737 - YeeU-like
Protein Data Bank (PDB) 3-D Structure MuPIT help
ModBase Predicted Comparative 3D Structure on O15217
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
CR749474 - Homo sapiens mRNA; cDNA DKFZp686D21185 (from clone DKFZp686D21185).BC015523 - Homo sapiens glutathione S-transferase alpha 4, mRNA (cDNA clone MGC:9318 IMAGE:3915425), complete cds.AF020918 - Homo sapiens glutathione transferase (GSTA4) mRNA, complete cds.AF025887 - Homo sapiens glutathione S-transferase A4-4 (GSTA4) mRNA, complete cds.BC096817 - Homo sapiens glutathione S-transferase A4, mRNA (cDNA clone IMAGE:5276991), with apparent retained intron.BC063439 - Homo sapiens glutathione S-transferase alpha 4, mRNA (cDNA clone MGC:74554 IMAGE:5248427), complete cds.AK054804 - Homo sapiens cDNA FLJ30242 fis, clone BRACE2002142, highly similar to GLUTATHIONE S-TRANSFERASE A4-4 (EC 2.5.1.18).JD490752 - Sequence 471776 from Patent EP1572962.JD518749 - Sequence 499773 from Patent EP1572962.JD429701 - Sequence 410725 from Patent EP1572962.JD421200 - Sequence 402224 from Patent EP1572962.JD396611 - Sequence 377635 from Patent EP1572962.AF125271 - Homo sapiens tissue-type pancreas glutathione S-transferase GSTA4-4 (GSTA4) mRNA, complete cds.AF125272 - Homo sapiens tissue-type heart hGSTA4-4 (GSTA4) mRNA, complete cds.AF125273 - Homo sapiens tissue-type skeletal muscle glutathione S-transferase GSTA4-4 (GSTA4) mRNA, complete cds.Y13047 - Homo sapiens mRNA for glutathione transferase A4-4.AK315369 - Homo sapiens cDNA, FLJ96415, Homo sapiens glutathione S-transferase A4 (GSTA4), mRNA.KJ901472 - Synthetic construct Homo sapiens clone ccsbBroadEn_10866 GSTA4 gene, encodes complete protein.CU677337 - Synthetic construct Homo sapiens gateway clone IMAGE:100018048 5' read GSTA4 mRNA.DQ890661 - Synthetic construct clone IMAGE:100003291; FLH164875.01X; RZPDo839D02158D glutathione S-transferase A4 (GSTA4) gene, encodes complete protein.KJ896937 - Synthetic construct Homo sapiens clone ccsbBroadEn_06331 GSTA4 gene, encodes complete protein.DQ893841 - Synthetic construct Homo sapiens clone IMAGE:100008301; FLH164871.01L; RZPDo839D02157D glutathione S-transferase A4 (GSTA4) gene, encodes complete protein.CU687722 - Synthetic construct Homo sapiens gateway clone IMAGE:100021507 5' read GSTA4 mRNA.AK074541 - Homo sapiens cDNA FLJ90060 fis, clone HEMBA1003294.BC071631 - Homo sapiens cDNA clone IMAGE:5240194, partial cds.JD496541 - Sequence 477565 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: B2RD15, ENST00000370963.1, ENST00000370963.2, ENST00000370963.3, ENST00000370963.4, ENST00000370963.5, ENST00000370963.6, ENST00000370963.7, ENST00000370963.8, GSTA4_HUMAN, NM_001512, O15217, Q5T7Q8, Q6P4G1, Q9BX18, Q9H414, uc318iui.1, uc318iui.2UCSC ID: ENST00000370963.9_8RefSeq Accession: NM_001512.4
Protein: O15217
(aka GSTA4_HUMAN)
Gene Model Information
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for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.