ID:GSTA4_HUMAN DESCRIPTION: RecName: Full=Glutathione S-transferase A4; EC=2.5.1.18; AltName: Full=GST class-alpha member 4; AltName: Full=Glutathione S-transferase A4-4; FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE). CATALYTIC ACTIVITY: RX + glutathione = HX + R-S-glutathione. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Expressed at a high level in brain, placenta, and skeletal muscle and much lower in lung and liver. SIMILARITY: Belongs to the GST superfamily. Alpha family. SIMILARITY: Contains 1 GST C-terminal domain. SIMILARITY: Contains 1 GST N-terminal domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gsta4/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15217
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004364 glutathione transferase activity GO:0005515 protein binding GO:0016740 transferase activity GO:0042802 identical protein binding GO:0042803 protein homodimerization activity
Biological Process: GO:0006749 glutathione metabolic process GO:0006805 xenobiotic metabolic process GO:0008152 metabolic process GO:1901687 glutathione derivative biosynthetic process
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
