ID:ERF3B_HUMAN DESCRIPTION: RecName: Full=Eukaryotic peptide chain release factor GTP-binding subunit ERF3B; Short=Eukaryotic peptide chain release factor subunit 3b; Short=eRF3b; AltName: Full=G1 to S phase transition protein 2 homolog; FUNCTION: Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. SUBUNIT: Interacts with ETF1 (By similarity). Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. Interacts with UPF1 and PABPC1. INTERACTION: P11940:PABPC1; NbExp=3; IntAct=EBI-3869637, EBI-81531; Q92900:UPF1; NbExp=3; IntAct=EBI-3869637, EBI-373471; SUBCELLULAR LOCATION: Cytoplasm (Probable). TISSUE SPECIFICITY: Highly expressed in IUCC stage II colorectal cancer (CRC). SIMILARITY: Belongs to the GTP-binding elongation factor family. ERF3 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IYD1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK225671 - Homo sapiens mRNA for peptide chain release factor 3 variant, clone: STM07487. LF211576 - JP 2014500723-A/19079: Polycomb-Associated Non-Coding RNAs. BC036077 - Homo sapiens G1 to S phase transition 2, mRNA (cDNA clone MGC:33729 IMAGE:5313878), complete cds. AK298868 - Homo sapiens cDNA FLJ55563 complete cds, highly similar to Homo sapiens G1 to S phase transition 2 (GSPT2), mRNA. AK023155 - Homo sapiens cDNA FLJ13093 fis, clone NT2RP3002151. AK001303 - Homo sapiens cDNA FLJ10441 fis, clone NT2RP1000733, highly similar to Human mRNA for GSPT1-TK protein. JD523521 - Sequence 504545 from Patent EP1572962. JD054964 - Sequence 35988 from Patent EP1572962. JD475942 - Sequence 456966 from Patent EP1572962. JD389875 - Sequence 370899 from Patent EP1572962. JD125048 - Sequence 106072 from Patent EP1572962. JD247565 - Sequence 228589 from Patent EP1572962. JD269356 - Sequence 250380 from Patent EP1572962. JD189047 - Sequence 170071 from Patent EP1572962. KJ898533 - Synthetic construct Homo sapiens clone ccsbBroadEn_07927 GSPT2 gene, encodes complete protein. AJ251548 - Homo sapiens mRNA for polypeptide chain release factor 3b (GSPT2 gene). LF381483 - JP 2014500723-A/188986: Polycomb-Associated Non-Coding RNAs. LF381484 - JP 2014500723-A/188987: Polycomb-Associated Non-Coding RNAs. LF381485 - JP 2014500723-A/188988: Polycomb-Associated Non-Coding RNAs. LF381486 - JP 2014500723-A/188989: Polycomb-Associated Non-Coding RNAs. JD369760 - Sequence 350784 from Patent EP1572962. JD265635 - Sequence 246659 from Patent EP1572962. JD501613 - Sequence 482637 from Patent EP1572962. JD555655 - Sequence 536679 from Patent EP1572962. JD367145 - Sequence 348169 from Patent EP1572962. JD280110 - Sequence 261134 from Patent EP1572962. JD561953 - Sequence 542977 from Patent EP1572962. MA447153 - JP 2018138019-A/19079: Polycomb-Associated Non-Coding RNAs. MA617060 - JP 2018138019-A/188986: Polycomb-Associated Non-Coding RNAs. MA617061 - JP 2018138019-A/188987: Polycomb-Associated Non-Coding RNAs. MA617062 - JP 2018138019-A/188988: Polycomb-Associated Non-Coding RNAs. MA617063 - JP 2018138019-A/188989: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8IYD1 (Reactome details) participates in the following event(s):
R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-6800138 N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-376176 Signaling by ROBO receptors R-HSA-72764 Eukaryotic Translation Termination R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-422475 Axon guidance R-HSA-72766 Translation R-HSA-8953854 Metabolism of RNA R-HSA-1266738 Developmental Biology R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
