Human Gene GRM4 (ENST00000538487.7_6) from GENCODE V47lift37

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Description: glutamate metabotropic receptor 4, transcript variant 8 (from RefSeq NM_001282847.2)
Gencode Transcript: ENST00000538487.7_6
Gencode Gene: ENSG00000124493.14_9
Transcript (Including UTRs)
Position: hg19 chr6:33,986,420-34,113,864 Size: 127,445 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr6:33,990,598-34,101,273 Size: 110,676 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:33,986,420-34,113,864)			mRNA (may differ from genome)		Protein (912 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed
Reactome	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GRM4_HUMAN DESCRIPTION: RecName: Full=Metabotropic glutamate receptor 4; Short=mGluR4; Flags: Precursor; FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. SUBUNIT: Interacts with PICK1 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. SIMILARITY: Belongs to the G-protein coupled receptor 3 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GRM4 Diseases sorted by gene-association score: epilepsy, generalized, with febrile seizures plus, type 5 (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C052383 1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene C523415 1-amino-2-phosphonomethylcyclopropanecarboxylic acid C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine C012729 2-amino-4-phosphonobutyric acid C553344 4-styrylpyrimidin-2-ylamine D000643 Ammonium Chloride D001285 Atropine D001564 Benzo(a)pyrene D002217 Carbachol more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 160.12 RPKM in Brain - Cerebellum Total median expression: 348.18 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-196.70	451	-0.436	Picture	PostScript	Text
3' UTR	-1789.80	4178	-0.428	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001828 - ANF_lig-bd_rcpt
IPR000337 - GPCR_3
IPR011500 - GPCR_3_9-Cys_dom
IPR017978 - GPCR_3_C
IPR017979 - GPCR_3_CS
IPR000162 - GPCR_3_mtglu_rcpt
IPR001786 - GPCR_3_mtglu_rcpt_4

Pfam Domains:
PF00003 - 7 transmembrane sweet-taste receptor of 3 GCPR
PF01094 - Receptor family ligand binding region
PF07562 - Nine Cysteines Domain of family 3 GPCR
PF13458 - Periplasmic binding protein

SCOP Domains:
53822 - Periplasmic binding protein-like I
57586 - TNF receptor-like
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on Q14833


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
		Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0008066 glutamate receptor activity Biological Process: GO:0000187 activation of MAPK activity GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway GO:0007268 chemical synaptic transmission GO:0007269 neurotransmitter secretion GO:0043410 positive regulation of MAPK cascade GO:0043523 regulation of neuron apoptotic process GO:0051966 regulation of synaptic transmission, glutamatergic Cellular Component: GO:0005622 intracellular GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0031410 cytoplasmic vesicle GO:0042734 presynaptic membrane

Descriptions from all associated GenBank mRNAs


	X80818 - H.sapiens mRNA for metabotropic glutamate receptor type 4. AK289524 - Homo sapiens cDNA FLJ78562 complete cds, highly similar to Homo sapiens glutamate receptor, metabotropic 4 (GRM4), mRNA. AK131536 - Homo sapiens cDNA FLJ16766 fis, clone BRAWH3013197, highly similar to Metabotropic glutamate receptor 4 precursor. U92457 - Human metabotropic glutamate receptor 4 mRNA, complete cds. BC130528 - Homo sapiens glutamate receptor, metabotropic 4, mRNA (cDNA clone MGC:163400 IMAGE:40146559), complete cds. BC144057 - Homo sapiens cDNA clone MGC:177594 IMAGE:9052577, complete cds. BC130526 - Homo sapiens glutamate receptor, metabotropic 4, mRNA (cDNA clone MGC:163398 IMAGE:40146557), complete cds. AK289534 - Homo sapiens cDNA FLJ77746 complete cds, highly similar to Homo sapiens glutamate receptor, metabotropic 4 (GRM4), mRNA. KJ905765 - Synthetic construct Homo sapiens clone ccsbBroadEn_15435 GRM4 gene, encodes complete protein. EU432124 - Homo sapiens glutamate metabotropic receptor 4 (GRM4) mRNA, complete cds. AK312300 - Homo sapiens cDNA, FLJ92605. HQ258665 - Synthetic construct Homo sapiens clone IMAGE:100072695 glutamate receptor, metabotropic 4 (GRM4) gene, encodes complete protein. HQ258669 - Synthetic construct Homo sapiens clone IMAGE:100072699 glutamate receptor, metabotropic 4 (GRM4) gene, encodes complete protein. KJ891300 - Synthetic construct Homo sapiens clone ccsbBroadEn_00694 GRM4 gene, encodes complete protein. AB385221 - Synthetic construct DNA, clone: pF1KB9462, Homo sapiens GRM4 gene for metabotropic glutamate receptor 4 precursor, complete cds, without stop codon, in Flexi system. AB209104 - Homo sapiens mRNA for glutamate receptor, metabotropic 4 variant protein. AK308669 - Homo sapiens cDNA, FLJ98710. JD406408 - Sequence 387432 from Patent EP1572962. JD124792 - Sequence 105816 from Patent EP1572962. JD124733 - Sequence 105757 from Patent EP1572962. JD157328 - Sequence 138352 from Patent EP1572962. JD256048 - Sequence 237072 from Patent EP1572962. JD269325 - Sequence 250349 from Patent EP1572962. JD233649 - Sequence 214673 from Patent EP1572962. AK126746 - Homo sapiens cDNA FLJ44792 fis, clone BRACE3039378, highly similar to Metabotropic glutamate receptor 4 precursor. AK122982 - Homo sapiens cDNA FLJ16736 fis, clone BRACE2006417, highly similar to METABOTROPIC GLUTAMATE RECEPTOR 4 PRECURSOR. AK122836 - Homo sapiens cDNA FLJ16445 fis, clone BRAMY3008937, highly similar to Metabotropic glutamate receptor 4 precursor. JD525605 - Sequence 506629 from Patent EP1572962. JD418478 - Sequence 399502 from Patent EP1572962. JD092414 - Sequence 73438 from Patent EP1572962. JD335065 - Sequence 316089 from Patent EP1572962. JD517090 - Sequence 498114 from Patent EP1572962. JD256253 - Sequence 237277 from Patent EP1572962. JD371548 - Sequence 352572 from Patent EP1572962. JD154543 - Sequence 135567 from Patent EP1572962. JD555037 - Sequence 536061 from Patent EP1572962. JD433166 - Sequence 414190 from Patent EP1572962. AK293913 - Homo sapiens cDNA FLJ56634 complete cds, highly similar to Metabotropic glutamate receptor 4 precursor. JD527756 - Sequence 508780 from Patent EP1572962. JD398152 - Sequence 379176 from Patent EP1572962. AK289563 - Homo sapiens cDNA FLJ77900 complete cds. JD078757 - Sequence 59781 from Patent EP1572962. JD125306 - Sequence 106330 from Patent EP1572962. JD196968 - Sequence 177992 from Patent EP1572962. AK293949 - Homo sapiens cDNA FLJ55961 complete cds, highly similar to Metabotropic glutamate receptor 4 precursor. JD334951 - Sequence 315975 from Patent EP1572962. JD104203 - Sequence 85227 from Patent EP1572962. JD387339 - Sequence 368363 from Patent EP1572962. JD123642 - Sequence 104666 from Patent EP1572962. JD385776 - Sequence 366800 from Patent EP1572962. JD343801 - Sequence 324825 from Patent EP1572962. JD189068 - Sequence 170092 from Patent EP1572962. JD471399 - Sequence 452423 from Patent EP1572962. JD493532 - Sequence 474556 from Patent EP1572962. JD347149 - Sequence 328173 from Patent EP1572962. JD270317 - Sequence 251341 from Patent EP1572962. JD344031 - Sequence 325055 from Patent EP1572962. JD437426 - Sequence 418450 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q14833 (Reactome details) participates in the following event(s): R-HSA-373075 Metabotropic glutamate receptors bind glutamate R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-388396 GPCR downstream signalling R-HSA-372790 Signaling by GPCR R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: B3KVL9, B7Z1T9, B7Z1U6, ENST00000538487.1, ENST00000538487.2, ENST00000538487.3, ENST00000538487.4, ENST00000538487.5, ENST00000538487.6, F5GXM5, GPRC1D, GRM4_HUMAN, MGLUR4, NM_001282847, Q14833, Q5SZ84, Q6ZMQ2, uc324qnn.1, uc324qnn.2 UCSC ID: ENST00000538487.7_6 RefSeq Accession: NM_000841.4 Protein: Q14833 (aka GRM4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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