ID:GRIA4_HUMAN DESCRIPTION: RecName: Full=Glutamate receptor 4; Short=GluR-4; Short=GluR4; AltName: Full=AMPA-selective glutamate receptor 4; AltName: Full=GluR-D; AltName: Full=Glutamate receptor ionotropic, AMPA 4; Short=GluA4; Flags: Precursor; FUNCTION: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with EPB41L1 via its C-terminus (By similarity). Found in a complex with GRIA1, GRIA2, GRIA3, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5 and PRKCG (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite. Note=Interaction with CNIH2, CNIH3 and PRKCG promotes cell surface expression (By similarity). PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-611 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). PTM: Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression (By similarity). MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate. SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA4 subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00060 - Ligand-gated ion channel PF00497 - Bacterial extracellular solute-binding proteins, family 3 PF01094 - Receptor family ligand binding region PF10613 - Ligated ion channel L-glutamate- and glycine-binding site
SCOP Domains: 53822 - Periplasmic binding protein-like I 53850 - Periplasmic binding protein-like II 81324 - Voltage-gated potassium channels
ModBase Predicted Comparative 3D Structure on P48058
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P48058 (Reactome details) participates in the following event(s):
R-HSA-420977 Ca permeable AMPA receptor ligand binding R-HSA-399712 Activation of Ca permeable AMPA receptors R-HSA-416320 Trafficking of GluR1-containing AMPA receptors R-HSA-420980 Activation of Ca permeable AMPA receptors R-HSA-416985 Trafficking of GluR2-containing AMPA receptors to synapse R-HSA-420975 Ca impermeable AMPA receptor ligand binding R-HSA-438037 Membrane depolarization upon activation of Ca impermeable AMPA receptors R-HSA-399711 Activation of Ca impermeable AMPA receptors R-HSA-416639 Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites R-HSA-421007 Endocytosis of Ca impermeable AMPA receptors R-HSA-8849881 SALM2 associate with AMPA and NMDA receptors R-HSA-432162 Unblocking of NMDA receptor R-HSA-399710 Activation of AMPA receptors R-HSA-399719 Trafficking of AMPA receptors R-HSA-416993 Trafficking of GluR2-containing AMPA receptors R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation R-HSA-8849932 Synaptic adhesion-like molecules R-HSA-399721 Glutamate binding, activation of AMPA receptors and synaptic plasticity R-HSA-442755 Activation of NMDA receptor and postsynaptic events R-HSA-6794362 Protein-protein interactions at synapses R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112316 Neuronal System R-HSA-112315 Transmission across Chemical Synapses
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Common Gene Haplotype Alleles 
