Human Gene GPX3 (ENST00000388825.9_9) from GENCODE V47lift37
  Description: glutathione peroxidase 3, transcript variant 1 (from RefSeq NM_002084.5)
Gencode Transcript: ENST00000388825.9_9
Gencode Gene: ENSG00000211445.13_15
Transcript (Including UTRs)
   Position: hg19 chr5:150,400,152-150,408,549 Size: 8,398 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr5:150,400,216-150,407,691 Size: 7,476 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:150,400,152-150,408,549)mRNA (may differ from genome)Protein (226 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPX3_HUMAN
DESCRIPTION: RecName: Full=Glutathione peroxidase 3; Short=GPx-3; Short=GSHPx-3; EC=1.11.1.9; AltName: Full=Extracellular glutathione peroxidase; AltName: Full=Plasma glutathione peroxidase; Short=GPx-P; Short=GSHPx-P; Flags: Precursor;
FUNCTION: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O.
SUBUNIT: Homotetramer.
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Secreted in plasma.
PTM: The N-terminus is blocked.
SIMILARITY: Belongs to the glutathione peroxidase family.
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx3/";
WEB RESOURCE: Name=Wikipedia; Note=Glutathione peroxidase entry; URL="http://en.wikipedia.org/wiki/Glutathione_peroxidase";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPX3
Diseases sorted by gene-association score: hepatocellular carcinoma (2), anemia of prematurity (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3054.72 RPKM in Kidney - Cortex
Total median expression: 24808.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -27.1064-0.423 Picture PostScript Text
3' UTR -295.90858-0.345 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000889 - Glutathione_peroxidase
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF00255 - Glutathione peroxidase

SCOP Domains:
52833 - Thioredoxin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2R37 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P22352
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008430 selenium binding
GO:0016491 oxidoreductase activity

Biological Process:
GO:0006979 response to oxidative stress
GO:0006982 response to lipid hydroperoxide
GO:0034599 cellular response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0051289 protein homotetramerization
GO:0055114 oxidation-reduction process
GO:0098869 cellular oxidant detoxification

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF209073 - JP 2014500723-A/16576: Polycomb-Associated Non-Coding RNAs.
HM005392 - Homo sapiens clone HTL-T-79 testicular tissue protein Li 79-like mRNA, complete sequence.
LF213981 - JP 2014500723-A/21484: Polycomb-Associated Non-Coding RNAs.
JD394588 - Sequence 375612 from Patent EP1572962.
AK310242 - Homo sapiens cDNA, FLJ17284.
BC066949 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone IMAGE:5262227), complete cds.
D00632 - Homo sapiens mRNA for glutathione peroxidase, complete cds.
BC025956 - Homo sapiens cDNA clone IMAGE:5440952.
BC035841 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone MGC:46126 IMAGE:5748087), complete cds.
BC050378 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone MGC:51890 IMAGE:5738272), complete cds.
JD206777 - Sequence 187801 from Patent EP1572962.
BC013218 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone IMAGE:4149458).
BC013601 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone MGC:8913 IMAGE:3882071), complete cds.
X58295 - Human GPx-3 mRNA for plasma glutathione peroxidase.
AF217787 - Homo sapiens extracellular glutathione peroxidase mRNA, complete cds.
CU690654 - Synthetic construct Homo sapiens gateway clone IMAGE:100021284 5' read GPX3 mRNA.
KJ891292 - Synthetic construct Homo sapiens clone ccsbBroadEn_00686 GPX3-like gene, encodes complete protein.
LF325865 - JP 2014500723-A/133368: Polycomb-Associated Non-Coding RNAs.
LF325867 - JP 2014500723-A/133370: Polycomb-Associated Non-Coding RNAs.
LF325868 - JP 2014500723-A/133371: Polycomb-Associated Non-Coding RNAs.
JD249112 - Sequence 230136 from Patent EP1572962.
LF325869 - JP 2014500723-A/133372: Polycomb-Associated Non-Coding RNAs.
JD144861 - Sequence 125885 from Patent EP1572962.
JD555405 - Sequence 536429 from Patent EP1572962.
JD455359 - Sequence 436383 from Patent EP1572962.
JD223773 - Sequence 204797 from Patent EP1572962.
JD233026 - Sequence 214050 from Patent EP1572962.
JD535655 - Sequence 516679 from Patent EP1572962.
JD438409 - Sequence 419433 from Patent EP1572962.
LF325870 - JP 2014500723-A/133373: Polycomb-Associated Non-Coding RNAs.
JD348333 - Sequence 329357 from Patent EP1572962.
LF325871 - JP 2014500723-A/133374: Polycomb-Associated Non-Coding RNAs.
JD412302 - Sequence 393326 from Patent EP1572962.
JD095429 - Sequence 76453 from Patent EP1572962.
JD403414 - Sequence 384438 from Patent EP1572962.
JD555685 - Sequence 536709 from Patent EP1572962.
JD230446 - Sequence 211470 from Patent EP1572962.
LF325872 - JP 2014500723-A/133375: Polycomb-Associated Non-Coding RNAs.
MA449558 - JP 2018138019-A/21484: Polycomb-Associated Non-Coding RNAs.
MA561442 - JP 2018138019-A/133368: Polycomb-Associated Non-Coding RNAs.
MA561444 - JP 2018138019-A/133370: Polycomb-Associated Non-Coding RNAs.
MA561445 - JP 2018138019-A/133371: Polycomb-Associated Non-Coding RNAs.
MA561446 - JP 2018138019-A/133372: Polycomb-Associated Non-Coding RNAs.
MA561447 - JP 2018138019-A/133373: Polycomb-Associated Non-Coding RNAs.
MA561448 - JP 2018138019-A/133374: Polycomb-Associated Non-Coding RNAs.
MA561449 - JP 2018138019-A/133375: Polycomb-Associated Non-Coding RNAs.
MA444650 - JP 2018138019-A/16576: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
DETOX1-PWY-1 - reactive oxygen species degradation
PWY-4081 - glutathione-peroxide redox reactions

Reactome (by CSHL, EBI, and GO)

Protein P22352 (Reactome details) participates in the following event(s):

R-HSA-3341397 GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-2262752 Cellular responses to stress
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000388825.1, ENST00000388825.2, ENST00000388825.3, ENST00000388825.4, ENST00000388825.5, ENST00000388825.6, ENST00000388825.7, ENST00000388825.8, GPX3 , GPX3_HUMAN, GPXP, NM_002084, O43787, P22352, Q86W78, Q9NZ74, Q9UEL1, uc318tag.1, uc318tag.2
UCSC ID: ENST00000388825.9_9
RefSeq Accession: NM_002084.5
Protein: P22352 (aka GPX3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.