Human Gene GPX3 (ENST00000388825.9_9) from GENCODE V47lift37

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Description: glutathione peroxidase 3, transcript variant 1 (from RefSeq NM_002084.5)
Gencode Transcript: ENST00000388825.9_9
Gencode Gene: ENSG00000211445.13_15
Transcript (Including UTRs)
Position: hg19 chr5:150,400,152-150,408,549 Size: 8,398 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr5:150,400,216-150,407,691 Size: 7,476 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr5:150,400,152-150,408,549)			mRNA (may differ from genome)		Protein (226 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GPX3_HUMAN DESCRIPTION: RecName: Full=Glutathione peroxidase 3; Short=GPx-3; Short=GSHPx-3; EC=1.11.1.9; AltName: Full=Extracellular glutathione peroxidase; AltName: Full=Plasma glutathione peroxidase; Short=GPx-P; Short=GSHPx-P; Flags: Precursor; FUNCTION: Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. CATALYTIC ACTIVITY: 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O. SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Secreted in plasma. PTM: The N-terminus is blocked. SIMILARITY: Belongs to the glutathione peroxidase family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx3/"; WEB RESOURCE: Name=Wikipedia; Note=Glutathione peroxidase entry; URL="http://en.wikipedia.org/wiki/Glutathione_peroxidase";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GPX3 Diseases sorted by gene-association score: hepatocellular carcinoma (2), anemia of prematurity (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D012643 Selenium D003907 Dexamethasone D013749 Tetrachlorodibenzodioxin C023035 3,4,5,3',4'-pentachlorobiphenyl D000082 Acetaminophen D001564 Benzo(a)pyrene D001556 Lindane D009569 Nitric Oxide D010269 Paraquat D011374 Progesterone more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 3054.72 RPKM in Kidney - Cortex Total median expression: 24808.90 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-27.10	64	-0.423	Picture	PostScript	Text
3' UTR	-295.90	858	-0.345	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000889 - Glutathione_peroxidase
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF00255 - Glutathione peroxidase

SCOP Domains:
52833 - Thioredoxin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

2R37 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P22352


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004601 peroxidase activity GO:0004602 glutathione peroxidase activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0008430 selenium binding GO:0016491 oxidoreductase activity Biological Process: GO:0006979 response to oxidative stress GO:0006982 response to lipid hydroperoxide GO:0034599 cellular response to oxidative stress GO:0042744 hydrogen peroxide catabolic process GO:0051289 protein homotetramerization GO:0055114 oxidation-reduction process GO:0098869 cellular oxidant detoxification Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	LF209073 - JP 2014500723-A/16576: Polycomb-Associated Non-Coding RNAs. HM005392 - Homo sapiens clone HTL-T-79 testicular tissue protein Li 79-like mRNA, complete sequence. LF213981 - JP 2014500723-A/21484: Polycomb-Associated Non-Coding RNAs. JD394588 - Sequence 375612 from Patent EP1572962. AK310242 - Homo sapiens cDNA, FLJ17284. BC066949 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone IMAGE:5262227), complete cds. D00632 - Homo sapiens mRNA for glutathione peroxidase, complete cds. BC025956 - Homo sapiens cDNA clone IMAGE:5440952. BC035841 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone MGC:46126 IMAGE:5748087), complete cds. BC050378 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone MGC:51890 IMAGE:5738272), complete cds. JD206777 - Sequence 187801 from Patent EP1572962. BC013218 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone IMAGE:4149458). BC013601 - Homo sapiens glutathione peroxidase 3 (plasma), mRNA (cDNA clone MGC:8913 IMAGE:3882071), complete cds. X58295 - Human GPx-3 mRNA for plasma glutathione peroxidase. AF217787 - Homo sapiens extracellular glutathione peroxidase mRNA, complete cds. CU690654 - Synthetic construct Homo sapiens gateway clone IMAGE:100021284 5' read GPX3 mRNA. KJ891292 - Synthetic construct Homo sapiens clone ccsbBroadEn_00686 GPX3-like gene, encodes complete protein. LF325865 - JP 2014500723-A/133368: Polycomb-Associated Non-Coding RNAs. LF325867 - JP 2014500723-A/133370: Polycomb-Associated Non-Coding RNAs. LF325868 - JP 2014500723-A/133371: Polycomb-Associated Non-Coding RNAs. JD249112 - Sequence 230136 from Patent EP1572962. LF325869 - JP 2014500723-A/133372: Polycomb-Associated Non-Coding RNAs. JD144861 - Sequence 125885 from Patent EP1572962. JD555405 - Sequence 536429 from Patent EP1572962. JD455359 - Sequence 436383 from Patent EP1572962. JD223773 - Sequence 204797 from Patent EP1572962. JD233026 - Sequence 214050 from Patent EP1572962. JD535655 - Sequence 516679 from Patent EP1572962. JD438409 - Sequence 419433 from Patent EP1572962. LF325870 - JP 2014500723-A/133373: Polycomb-Associated Non-Coding RNAs. JD348333 - Sequence 329357 from Patent EP1572962. LF325871 - JP 2014500723-A/133374: Polycomb-Associated Non-Coding RNAs. JD412302 - Sequence 393326 from Patent EP1572962. JD095429 - Sequence 76453 from Patent EP1572962. JD403414 - Sequence 384438 from Patent EP1572962. JD555685 - Sequence 536709 from Patent EP1572962. JD230446 - Sequence 211470 from Patent EP1572962. LF325872 - JP 2014500723-A/133375: Polycomb-Associated Non-Coding RNAs. MA449558 - JP 2018138019-A/21484: Polycomb-Associated Non-Coding RNAs. MA561442 - JP 2018138019-A/133368: Polycomb-Associated Non-Coding RNAs. MA561444 - JP 2018138019-A/133370: Polycomb-Associated Non-Coding RNAs. MA561445 - JP 2018138019-A/133371: Polycomb-Associated Non-Coding RNAs. MA561446 - JP 2018138019-A/133372: Polycomb-Associated Non-Coding RNAs. MA561447 - JP 2018138019-A/133373: Polycomb-Associated Non-Coding RNAs. MA561448 - JP 2018138019-A/133374: Polycomb-Associated Non-Coding RNAs. MA561449 - JP 2018138019-A/133375: Polycomb-Associated Non-Coding RNAs. MA444650 - JP 2018138019-A/16576: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library DETOX1-PWY-1 - reactive oxygen species degradation PWY-4081 - glutathione-peroxide redox reactions Reactome (by CSHL, EBI, and GO) Protein P22352 (Reactome details) participates in the following event(s): R-HSA-3341397 GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O R-HSA-3299685 Detoxification of Reactive Oxygen Species R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli

Other Names for This Gene


	Alternate Gene Symbols: ENST00000388825.1, ENST00000388825.2, ENST00000388825.3, ENST00000388825.4, ENST00000388825.5, ENST00000388825.6, ENST00000388825.7, ENST00000388825.8, GPX3 , GPX3_HUMAN, GPXP, NM_002084, O43787, P22352, Q86W78, Q9NZ74, Q9UEL1, uc318tag.1, uc318tag.2 UCSC ID: ENST00000388825.9_9 RefSeq Accession: NM_002084.5 Protein: P22352 (aka GPX3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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