Human Gene GPX1 (ENST00000419783.3_16) from GENCODE V47lift37
  Description: glutathione peroxidase 1, transcript variant 1 (from RefSeq NM_000581.4)
Gencode Transcript: ENST00000419783.3_16
Gencode Gene: ENSG00000233276.9_18
Transcript (Including UTRs)
   Position: hg19 chr3:49,394,609-49,395,786 Size: 1,178 Total Exon Count: 2 Strand: -
Coding Region
   Position: hg19 chr3:49,394,821-49,395,711 Size: 891 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:49,394,609-49,395,786)mRNA (may differ from genome)Protein (203 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q7L4Q3_HUMAN
DESCRIPTION: RecName: Full=Glutathione peroxidase;
SIMILARITY: Belongs to the glutathione peroxidase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPX1
Diseases sorted by gene-association score: hemolytic anemia due to glutathione peroxidase deficiency* (150), keshan disease (24), vulvar leiomyosarcoma (15), vulvar sarcoma (10), ileocolitis (10), breast cancer (2), oral cavity cancer (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 186.34 RPKM in Whole Blood
Total median expression: 3735.30 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -29.7075-0.396 Picture PostScript Text
3' UTR -78.00212-0.368 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000889 - Glutathione_peroxidase
IPR012336 - Thioredoxin-like_fold

Pfam Domains:
PF00255 - Glutathione peroxidase

SCOP Domains:
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q7L4Q3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
GO:0016491 oxidoreductase activity

Biological Process:
GO:0000302 response to reactive oxygen species
GO:0001659 temperature homeostasis
GO:0001885 endothelial cell development
GO:0002862 negative regulation of inflammatory response to antigenic stimulus
GO:0006629 lipid metabolic process
GO:0006641 triglyceride metabolic process
GO:0006915 apoptotic process
GO:0006979 response to oxidative stress
GO:0007605 sensory perception of sound
GO:0008283 cell proliferation
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0009410 response to xenobiotic stimulus
GO:0009609 response to symbiotic bacterium
GO:0009611 response to wounding
GO:0009636 response to toxic substance
GO:0010332 response to gamma radiation
GO:0014902 myotube differentiation
GO:0018158 protein oxidation
GO:0033194 response to hydroperoxide
GO:0042311 vasodilation
GO:0042542 response to hydrogen peroxide
GO:0042744 hydrogen peroxide catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043403 skeletal muscle tissue regeneration
GO:0043523 regulation of neuron apoptotic process
GO:0043534 blood vessel endothelial cell migration
GO:0045444 fat cell differentiation
GO:0048741 skeletal muscle fiber development
GO:0051450 myoblast proliferation
GO:0051702 interaction with symbiont
GO:0051897 positive regulation of protein kinase B signaling
GO:0055114 oxidation-reduction process
GO:0060047 heart contraction
GO:0060055 angiogenesis involved in wound healing
GO:0098869 cellular oxidant detoxification
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component:
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  AK225835 - Homo sapiens mRNA for Glutathione peroxidase 1 variant, clone: FCC127C01.
BC007865 - Homo sapiens glutathione peroxidase 1, mRNA (cDNA clone MGC:14399 IMAGE:4301275), complete cds.
HM005391 - Homo sapiens clone HTL-T-78 testicular tissue protein Li 78-like mRNA, complete sequence.
X13710 - H.sapiens unspliced mRNA for glutathione peroxidase.
AK130160 - Homo sapiens cDNA FLJ26650 fis, clone MPE04848, highly similar to Glutathione peroxidase (EC 1.11.1.9).
BC070258 - Homo sapiens glutathione peroxidase 1, mRNA (cDNA clone MGC:88245 IMAGE:6452792), complete cds.
BC000742 - Homo sapiens glutathione peroxidase 1, mRNA (cDNA clone MGC:2335 IMAGE:3505654), complete cds.
E01717 - DNA sequence coding for human glutathione peroxidase.
Y00433 - Human mRNA for glutathione peroxidase (EC 1.11.1.9.).
X13709 - Human gpx1 mRNA for gluthatione peroxidase.
M21304 - Human glutathione peroxidase (GPX1) mRNA, complete cds.
JD545938 - Sequence 526962 from Patent EP1572962.
JD322101 - Sequence 303125 from Patent EP1572962.
JD399173 - Sequence 380197 from Patent EP1572962.
JD239795 - Sequence 220819 from Patent EP1572962.
JD241904 - Sequence 222928 from Patent EP1572962.
KJ901464 - Synthetic construct Homo sapiens clone ccsbBroadEn_10858 GPX1 gene, encodes complete protein.
KR709800 - Synthetic construct Homo sapiens clone CCSBHm_00006150 GPX1 (GPX1) mRNA, encodes complete protein.
KJ891291 - Synthetic construct Homo sapiens clone ccsbBroadEn_00685 GPX1-like gene, encodes complete protein.
KJ534852 - Homo sapiens clone GPX1_iso-A_adult-A04 glutathione peroxidase 1 isoform A (GPX1) mRNA, complete cds, alternatively spliced.
KJ534853 - Homo sapiens clone GPX1_iso-A_fetal-F02 glutathione peroxidase 1 isoform A (GPX1) mRNA, complete cds, alternatively spliced.
D28370 - Homo sapiens mRNA for glutathione peroxidase, 5'UTR region.
JD272805 - Sequence 253829 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
DETOX1-PWY-1 - reactive oxygen species degradation
PWY-4081 - glutathione-peroxide redox reactions

BioCarta from NCI Cancer Genome Anatomy Project
h_freePathway - Free Radical Induced Apoptosis
h_flumazenilPathway - Cardiac Protection Against ROS

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000419783.1, ENST00000419783.2, GPX1 , NM_000581, Q7L4Q3, Q7L4Q3_HUMAN, uc319phk.1, uc319phk.2
UCSC ID: ENST00000419783.3_16
RefSeq Accession: NM_000581.4
Protein: Q7L4Q3

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.