Human Gene GPR62 (ENST00000322241.6_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 62 (from RefSeq NM_080865.4)
Gencode Transcript: ENST00000322241.6_4
Gencode Gene: ENSG00000180929.6_7
Transcript (Including UTRs)
   Position: hg19 chr3:51,989,397-51,991,515 Size: 2,119 Total Exon Count: 1 Strand: +
Coding Region
   Position: hg19 chr3:51,989,669-51,990,775 Size: 1,107 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:51,989,397-51,991,515)mRNA (may differ from genome)Protein (368 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR62_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 62; AltName: Full=G-protein coupled receptor GPCR8; Short=hGPCR8; AltName: Full=G-protein coupled receptor KPG_005;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -104.20272-0.383 Picture PostScript Text
3' UTR -275.80740-0.373 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9BZJ7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:1990763 arrestin family protein binding

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0048016 inositol phosphate-mediated signaling

Cellular Component:
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex


-  Descriptions from all associated GenBank mRNAs
  AB032600 - Homo sapiens KPG_005 mRNA for G-protein coupled receptor, complete cds.
BC026357 - Homo sapiens G protein-coupled receptor 62, mRNA (cDNA clone MGC:26943 IMAGE:4812283), complete cds.
JD352765 - Sequence 333789 from Patent EP1572962.
JD318432 - Sequence 299456 from Patent EP1572962.
JD540705 - Sequence 521729 from Patent EP1572962.
JD480301 - Sequence 461325 from Patent EP1572962.
JD480302 - Sequence 461326 from Patent EP1572962.
JD534544 - Sequence 515568 from Patent EP1572962.
JD217150 - Sequence 198174 from Patent EP1572962.
JD361403 - Sequence 342427 from Patent EP1572962.
JD071182 - Sequence 52206 from Patent EP1572962.
JD471343 - Sequence 452367 from Patent EP1572962.
JD362126 - Sequence 343150 from Patent EP1572962.
JD178199 - Sequence 159223 from Patent EP1572962.
JD229096 - Sequence 210120 from Patent EP1572962.
JD341617 - Sequence 322641 from Patent EP1572962.
JD117394 - Sequence 98418 from Patent EP1572962.
AB385075 - Synthetic construct DNA, clone: pF1KB5268, Homo sapiens GPR62 gene for G-protein coupled receptor 62, complete cds, without stop codon, in Flexi system.
HQ709188 - Homo sapiens G protein-coupled receptor 62 (GPR62) mRNA, complete cds.
JD151143 - Sequence 132167 from Patent EP1572962.
JD255503 - Sequence 236527 from Patent EP1572962.
JD400854 - Sequence 381878 from Patent EP1572962.
JD155639 - Sequence 136663 from Patent EP1572962.
JD471301 - Sequence 452325 from Patent EP1572962.
JD442646 - Sequence 423670 from Patent EP1572962.
JD209778 - Sequence 190802 from Patent EP1572962.
JD344337 - Sequence 325361 from Patent EP1572962.
JD324203 - Sequence 305227 from Patent EP1572962.
JD253094 - Sequence 234118 from Patent EP1572962.
JD438581 - Sequence 419605 from Patent EP1572962.
JD053669 - Sequence 34693 from Patent EP1572962.
JD360953 - Sequence 341977 from Patent EP1572962.
JD038630 - Sequence 19654 from Patent EP1572962.
JD551562 - Sequence 532586 from Patent EP1572962.
JD485786 - Sequence 466810 from Patent EP1572962.
JD486091 - Sequence 467115 from Patent EP1572962.
JD371782 - Sequence 352806 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000322241.1, ENST00000322241.2, ENST00000322241.3, ENST00000322241.4, ENST00000322241.5, F1DAM4, GPR62_HUMAN, NM_080865, Q5KU27, Q9BZJ7, uc317rfy.1, uc317rfy.2
UCSC ID: ENST00000322241.6_4
RefSeq Accession: NM_080865.4
Protein: Q9BZJ7 (aka GPR62_HUMAN or GP62_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.