Human Gene GPR3 (ENST00000374024.4_5) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: GPR3_HUMAN
DESCRIPTION: RecName: Full=G-protein coupled receptor 3; AltName: Full=ACCA orphan receptor;
FUNCTION: Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.
INDUCTION: Overexpression stimulates amyloid-beta production.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CAUTION: Was originally (PubMed:12220620) thought to be a receptor for sphingosine 1-phosphate. PubMed:19286662 demonstrated that it is not the case.
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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The following chemicals interact with this gene
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 Common Gene Haplotype Alleles
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Press "+" in the title bar above to open this section.
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR000984 - GPR3_rcpt
IPR000723 - GPR_orph_rcpt
Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
SCOP Domains:
81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on P46089
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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LF211961 - JP 2014500723-A/19464: Polycomb-Associated Non-Coding RNAs.
BC032702 - Homo sapiens G protein-coupled receptor 3, mRNA (cDNA clone MGC:45242 IMAGE:5247608), complete cds.
AK291185 - Homo sapiens cDNA FLJ78018 complete cds, highly similar to Homo sapiens G protein-coupled receptor 3, mRNA.
AK314868 - Homo sapiens cDNA, FLJ95769, Homo sapiens G protein-coupled receptor 3 (GPR3), mRNA.
DQ893987 - Synthetic construct Homo sapiens clone IMAGE:100008447; FLH166302.01L; RZPDo839F0485D G protein-coupled receptor 3 (GPR3) gene, encodes complete protein.
DQ890832 - Synthetic construct clone IMAGE:100003462; FLH166306.01X; RZPDo839F0486D G protein-coupled receptor 3 (GPR3) gene, encodes complete protein.
AB464543 - Synthetic construct DNA, clone: pF1KB8794, Homo sapiens GPR3 gene for G protein-coupled receptor 3, without stop codon, in Flexi system.
KJ891275 - Synthetic construct Homo sapiens clone ccsbBroadEn_00669 GPR3 gene, encodes complete protein.
HQ709189 - Homo sapiens G protein-coupled receptor 3 (GPR3) mRNA, complete cds.
JD103231 - Sequence 84255 from Patent EP1572962.
JD329341 - Sequence 310365 from Patent EP1572962.
JD549669 - Sequence 530693 from Patent EP1572962.
JD168425 - Sequence 149449 from Patent EP1572962.
JD317455 - Sequence 298479 from Patent EP1572962.
JD292304 - Sequence 273328 from Patent EP1572962.
JD357836 - Sequence 338860 from Patent EP1572962.
JD456266 - Sequence 437290 from Patent EP1572962.
JD101707 - Sequence 82731 from Patent EP1572962.
JD107065 - Sequence 88089 from Patent EP1572962.
JD436293 - Sequence 417317 from Patent EP1572962.
JD506797 - Sequence 487821 from Patent EP1572962.
JD379143 - Sequence 360167 from Patent EP1572962.
JD294512 - Sequence 275536 from Patent EP1572962.
JD037445 - Sequence 18469 from Patent EP1572962.
JD088955 - Sequence 69979 from Patent EP1572962.
JD268812 - Sequence 249836 from Patent EP1572962.
JD185110 - Sequence 166134 from Patent EP1572962.
JD095116 - Sequence 76140 from Patent EP1572962.
JD041547 - Sequence 22571 from Patent EP1572962.
JD387771 - Sequence 368795 from Patent EP1572962.
JD149004 - Sequence 130028 from Patent EP1572962.
JD355594 - Sequence 336618 from Patent EP1572962.
JD094667 - Sequence 75691 from Patent EP1572962.
MA447538 - JP 2018138019-A/19464: Polycomb-Associated Non-Coding RNAs.
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Other Names for This Gene
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Alternate Gene Symbols: A8K570, ACCA, ENST00000374024.1, ENST00000374024.2, ENST00000374024.3, GPR3_HUMAN, NM_005281, P46089, uc318lgl.1, uc318lgl.2
UCSC ID: ENST00000374024.4_5
RefSeq Accession: NM_005281.4
Protein: P46089
(aka GPR3_HUMAN)
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Gene Model Information
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Click here
for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
