Human Gene GPR19 (ENST00000651487.1_6) from GENCODE V47lift37
  Description: G protein-coupled receptor 19 (from RefSeq NM_006143.3)
Gencode Transcript: ENST00000651487.1_6
Gencode Gene: ENSG00000183150.8_12
Transcript (Including UTRs)
   Position: hg19 chr12:12,813,824-12,849,117 Size: 35,294 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg19 chr12:12,814,135-12,815,382 Size: 1,248 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:12,813,824-12,849,117)mRNA (may differ from genome)Protein (415 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCHuman Cortex Gene ExpressionMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GPR19_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 19; AltName: Full=GPR-NGA;
FUNCTION: Orphan receptor.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Abundant expression in the brain.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -108.60351-0.309 Picture PostScript Text
3' UTR -46.60311-0.150 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q15760
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007631 feeding behavior

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK096388 - Homo sapiens cDNA FLJ39069 fis, clone NT2RP7015431.
AK074729 - Homo sapiens cDNA FLJ90248 fis, clone NT2RM2001939, highly similar to Probable G-protein coupled receptor 19.
BC150599 - Homo sapiens G protein-coupled receptor 19, mRNA (cDNA clone MGC:183509 IMAGE:9056969), complete cds.
JD296077 - Sequence 277101 from Patent EP1572962.
CR456832 - Homo sapiens full open reading frame cDNA clone RZPDo834E0618D for gene GPR19, G protein-coupled receptor 19; complete cds, incl. stopcodon.
JQ308175 - Homo sapiens G protein-coupled receptor 19 mRNA, complete cds.

-  Other Names for This Gene
  Alternate Gene Symbols: GPR19_HUMAN, NM_006143, Q15760, uc328tag.1, uc328tag.2
UCSC ID: ENST00000651487.1_6
RefSeq Accession: NM_006143.3
Protein: Q15760 (aka GPR19_HUMAN or GP19_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.