Human Gene GPR17 (ENST00000486700.2_4) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: G protein-coupled receptor 17, transcript variant 4 (from RefSeq NM_001161417.2)
Gencode Transcript: ENST00000486700.2_4
Gencode Gene: ENSG00000144230.17_7
Transcript (Including UTRs)
Position: hg19 chr2:128,403,728-128,410,213 Size: 6,486 Total Exon Count: 2 Strand: +
Coding Region
Position: hg19 chr2:128,408,310-128,409,329 Size: 1,020 Coding Exon Count: 1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:128,403,728-128,410,213)			mRNA (may differ from genome)		Protein (339 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GPR17_HUMAN DESCRIPTION: RecName: Full=Uracil nucleotide/cysteinyl leukotriene receptor; Short=UDP/CysLT receptor; AltName: Full=G-protein coupled receptor 17; AltName: Full=P2Y-like receptor; AltName: Full=R12; FUNCTION: Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in brain, kidney, heart and umbilical vein endothelial cells. Highest level in brain. SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GPR17 Diseases sorted by gene-association score: suppression amblyopia (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D000535 Aluminum D001564 Benzo(a)pyrene D004958 Estradiol D017997 Leukotriene C4 D017998 Leukotriene D4 D017999 Leukotriene E4 D011374 Progesterone D013749 Tetrachlorodibenzodioxin D014530 Uridine Diphosphate more ... click here to view the complete list

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 14.47 RPKM in Brain - Amygdala Total median expression: 248.68 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-29.50	112	-0.263	Picture	PostScript	Text
3' UTR	-309.10	884	-0.350	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR002286 - P2_purnocptor

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q13304


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0004950 chemokine receptor activity GO:0033612 receptor serine/threonine kinase binding Biological Process: GO:0002376 immune system process GO:0002862 negative regulation of inflammatory response to antigenic stimulus GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0035025 positive regulation of Rho protein signal transduction GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0070098 chemokine-mediated signaling pathway Cellular Component: GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AK292725 - Homo sapiens cDNA FLJ75420 complete cds, highly similar to H.sapiens mRNA for P2Y-like G-protein coupled receptor. BX538082 - Homo sapiens mRNA; cDNA DKFZp686M18273 (from clone DKFZp686M18273); complete cds. BC013202 - Homo sapiens cDNA clone IMAGE:4214482, containing frame-shift errors. Z94154 - H.sapiens mRNA for P2Y-like G-protein coupled receptor. Y12546 - H.sapiens mRNA for P2Y-like G-protein coupled receptor. BC031653 - Homo sapiens G protein-coupled receptor 17, mRNA (cDNA clone MGC:35264 IMAGE:5174146), complete cds. JD175621 - Sequence 156645 from Patent EP1572962. JD351242 - Sequence 332266 from Patent EP1572962. AK126849 - Homo sapiens cDNA FLJ44901 fis, clone BRAMY3004126, highly similar to Probable P2Y purinoceptor GPR17. AK313949 - Homo sapiens cDNA, FLJ94593, Homo sapiens G protein-coupled receptor 17 (GPR17), mRNA. BC039595 - Homo sapiens G protein-coupled receptor 17, mRNA (cDNA clone IMAGE:4156560). KJ896917 - Synthetic construct Homo sapiens clone ccsbBroadEn_06311 GPR17 gene, encodes complete protein. DQ892453 - Synthetic construct clone IMAGE:100005083; FLH186465.01X; RZPDo839E1071D G protein-coupled receptor 17 (GPR17) gene, encodes complete protein. DQ895665 - Synthetic construct Homo sapiens clone IMAGE:100010125; FLH186461.01L; RZPDo839E1061D G protein-coupled receptor 17 (GPR17) gene, encodes complete protein. JF810891 - Homo sapiens G protein-coupled receptor 17 isoform b (GPR17) mRNA, complete cds. Z94155 - H.sapiens mRNA for P2Y-like G-protein coupled receptor (partial). JD140751 - Sequence 121775 from Patent EP1572962. JD563526 - Sequence 544550 from Patent EP1572962. JD457886 - Sequence 438910 from Patent EP1572962. JD275217 - Sequence 256241 from Patent EP1572962. JD049369 - Sequence 30393 from Patent EP1572962. JD540889 - Sequence 521913 from Patent EP1572962. JD067997 - Sequence 49021 from Patent EP1572962. JD102326 - Sequence 83350 from Patent EP1572962. JD074961 - Sequence 55985 from Patent EP1572962. JD081368 - Sequence 62392 from Patent EP1572962. JD501123 - Sequence 482147 from Patent EP1572962. JD274084 - Sequence 255108 from Patent EP1572962. JD444184 - Sequence 425208 from Patent EP1572962. JD075512 - Sequence 56536 from Patent EP1572962. JD218568 - Sequence 199592 from Patent EP1572962. JD422597 - Sequence 403621 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q13304 (Reactome details) participates in the following event(s): R-HSA-391937 UDP/CysLT receptor can bind cysteinyl leukotrienes R-HSA-418918 The UDP/CysLT (P2Y17) receptor can bind UTP R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749452 The Ligand:GPCR:Gq complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 R-HSA-391906 Leukotriene receptors R-HSA-417957 P2Y receptors R-HSA-418594 G alpha (i) signalling events R-HSA-416476 G alpha (q) signalling events R-HSA-391903 Eicosanoid ligand-binding receptors R-HSA-418038 Nucleotide-like (purinergic) receptors R-HSA-388396 GPCR downstream signalling R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-372790 Signaling by GPCR R-HSA-500792 GPCR ligand binding R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: A8K9L0, B2R9X0, ENST00000486700.1, GPR17_HUMAN, NM_001161417, Q13304, Q8N5S7, Q9UDZ6, Q9UE21, uc322gub.1, uc322gub.2 UCSC ID: ENST00000486700.2_4 RefSeq Accession: NM_001161417.2 Protein: Q13304 (aka GPR17_HUMAN or GP17_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.