Human Gene GPR142 (ENST00000582579.6_4) from GENCODE V47lift37
  Description: G protein-coupled receptor 142, transcript variant 3 (from RefSeq NM_001331077.1)
Gencode Transcript: ENST00000582579.6_4
Gencode Gene: ENSG00000257008.7_8
Transcript (Including UTRs)
   Position: hg19 chr17:72,363,645-72,368,739 Size: 5,095 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr17:72,365,680-72,368,739 Size: 3,060 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:72,363,645-72,368,739)mRNA (may differ from genome)Protein (374 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: J3QSD0_HUMAN
DESCRIPTION: SubName: Full=Probable G-protein-coupled receptor 142;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: GPR142
Diseases sorted by gene-association score: hypotrichosis 1 (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.75 RPKM in Spleen
Total median expression: 4.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -127.80362-0.353 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024034 - ATPase_F1_bsu/V1_C

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)

SCOP Domains:
69118 - AhpD-like
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on J3QSD0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Descriptions from all associated GenBank mRNAs
  BC143807 - Homo sapiens cDNA clone IMAGE:9052322, with apparent retained intron.
AB528868 - Synthetic construct DNA, clone: pF1KE0589, Homo sapiens GPR142 gene for G protein-coupled receptor 142, without stop codon, in Flexi system.
BC152987 - Synthetic construct Homo sapiens clone IMAGE:100016251, MGC:184239 G protein-coupled receptor 142 (GPR142) mRNA, encodes complete protein.
AB196530 - Homo sapiens GPRg1b mRNA for G protein-coupled receptor, complete cds.
AY288421 - Homo sapiens G protein-coupled receptor 142 (GPR142) mRNA, complete cds.
BC152734 - Synthetic construct Homo sapiens clone IMAGE:100015986, MGC:184116 G protein-coupled receptor 142 (GPR142) mRNA, encodes complete protein.
KT749966 - Homo sapiens G-protein coupled receptor 142 long form (GPR142) mRNA, complete cds.
KT749967 - Homo sapiens G-protein coupled receptor 142 short form (GPR142) mRNA, complete cds.
AY255622 - Homo sapiens G protein-coupled receptor PGR2 mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000582579.1, ENST00000582579.2, ENST00000582579.3, ENST00000582579.4, ENST00000582579.5, GPR142 , J3QSD0, J3QSD0_HUMAN, NM_001331077, uc326lip.1, uc326lip.2
UCSC ID: ENST00000582579.6_4
RefSeq Accession: NM_001331076.1
Protein: J3QSD0

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.