Human Gene ADGRA3 (ENST00000334304.10_7) from GENCODE V47lift37
  Description: adhesion G protein-coupled receptor A3 (from RefSeq NM_145290.4)
Gencode Transcript: ENST00000334304.10_7
Gencode Gene: ENSG00000152990.14_10
Transcript (Including UTRs)
   Position: hg19 chr4:22,388,999-22,517,689 Size: 128,691 Total Exon Count: 19 Strand: -
Coding Region
   Position: hg19 chr4:22,389,328-22,517,407 Size: 128,080 Coding Exon Count: 19 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesGeneReviewsModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:22,388,999-22,517,689)mRNA (may differ from genome)Protein (1321 aa)
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MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP125_HUMAN
DESCRIPTION: RecName: Full=Probable G-protein coupled receptor 125; Flags: Precursor;
FUNCTION: Orphan receptor.
SUBUNIT: Interacts with DLG1.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
DOMAIN: Binds to DLG1 through its PDZ-binding motif (By similarity).
SIMILARITY: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
SIMILARITY: Contains 1 GPS domain.
SIMILARITY: Contains 1 Ig-like (immunoglobulin-like) domain.
SIMILARITY: Contains 5 LRR (leucine-rich) repeats.
SIMILARITY: Contains 1 LRRCT domain.
SEQUENCE CAUTION: Sequence=AAH35645.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: ADGRA3
Diseases sorted by gene-association score: schizophrenia (1)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.58 RPKM in Liver
Total median expression: 274.80 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -167.60282-0.594 Picture PostScript Text
3' UTR -60.10329-0.183 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000483 - Cys-rich_flank_reg_C
IPR017981 - GPCR_2-like
IPR001879 - GPCR_2_extracellular_dom
IPR000832 - GPCR_2_secretin-like
IPR000203 - GPS_dom
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR001611 - Leu-rich_rpt
IPR003591 - Leu-rich_rpt_typical-subtyp

Pfam Domains:
PF00002 - 7 transmembrane receptor (Secretin family)
PF01825 - GPCR proteolysis site, GPS, motif
PF07679 - Immunoglobulin I-set domain
PF13306 - BspA type Leucine rich repeat region (6 copies)
PF13855 - Leucine rich repeat

SCOP Domains:
48726 - Immunoglobulin
51351 - Triosephosphate isomerase (TIM)
52047 - RNI-like
52058 - L domain-like
52075 - Outer arm dynein light chain 1
81321 - Family A G protein-coupled receptor-like
81324 - Voltage-gated potassium channels
57535 - Complement control module/SCR domain
111418 - Hormone receptor domain

ModBase Predicted Comparative 3D Structure on Q8IWK6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0005515 protein binding

Biological Process:
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway

Cellular Component:
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AL832257 - Homo sapiens mRNA; cDNA DKFZp667E2417 (from clone DKFZp667E2417).
AK095866 - Homo sapiens cDNA FLJ38547 fis, clone HCHON2001665, highly similar to Probable G-protein coupled receptor 125 precursor.
AK299168 - Homo sapiens cDNA FLJ61345 complete cds, highly similar to Probable G-protein coupled receptor 125 precursor.
AY181243 - Homo sapiens G protein-coupled receptor 125 (GPR125) mRNA, partial cds.
BC035645 - Homo sapiens, Similar to RIKEN cDNA 3830613O22 gene, clone IMAGE:5551209, mRNA, partial cds.
AK027494 - Homo sapiens cDNA FLJ14588 fis, clone NT2RM4001819, highly similar to Human p58/GTA (galactosyltransferase associated protein kinase) mRNA.
KJ903950 - Synthetic construct Homo sapiens clone ccsbBroadEn_13344 GPR125 gene, encodes complete protein.
BX648287 - Homo sapiens mRNA; cDNA DKFZp686E18131 (from clone DKFZp686E18131).
M37712 - Homo sapiens p58/GTA protein kinase mRNA, complete cds.
JD310689 - Sequence 291713 from Patent EP1572962.
JD437057 - Sequence 418081 from Patent EP1572962.
JD224334 - Sequence 205358 from Patent EP1572962.
AY360366 - Homo sapiens TEM5-like protein mRNA, partial cds.
JD058110 - Sequence 39134 from Patent EP1572962.
BC026009 - Homo sapiens G protein-coupled receptor 125, mRNA (cDNA clone IMAGE:4714761).
AY358306 - Homo sapiens clone DNA57254 GPR125 (UNQ556) mRNA, complete cds.
CU693098 - Synthetic construct Homo sapiens gateway clone IMAGE:100022280 5' read GPR125 mRNA.
JD068282 - Sequence 49306 from Patent EP1572962.
JD036808 - Sequence 17832 from Patent EP1572962.
JD500829 - Sequence 481853 from Patent EP1572962.
JD551663 - Sequence 532687 from Patent EP1572962.
AF064846 - Homo sapiens map 18p11; 7cR from WI-5607 repeat region, complete sequence.

-  Other Names for This Gene
  Alternate Gene Symbols: ADGRA3 , AGRA3_HUMAN, ENST00000334304.1, ENST00000334304.2, ENST00000334304.3, ENST00000334304.4, ENST00000334304.5, ENST00000334304.6, ENST00000334304.7, ENST00000334304.8, ENST00000334304.9, GPR125, NM_145290, Q6UXK9, Q86SQ5, Q8IWK6, Q8TC55, uc317txn.1, uc317txn.2, UNQ556/PRO1113
UCSC ID: ENST00000334304.10_7
RefSeq Accession: NM_145290.4
Protein: Q8IWK6 (aka GP125_HUMAN or G125_HUMAN)

-  GeneReviews for This Gene
  GeneReviews article(s) related to gene ADGRA3:
rp-overview (Nonsyndromic Retinitis Pigmentosa Overview)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.