Human Gene GPR107 (ENST00000347136.11_6) from GENCODE V47lift37
  Description: G protein-coupled receptor 107, transcript variant 3 (from RefSeq NM_020960.5)
Gencode Transcript: ENST00000347136.11_6
Gencode Gene: ENSG00000148358.21_9
Transcript (Including UTRs)
   Position: hg19 chr9:132,816,185-132,902,443 Size: 86,259 Total Exon Count: 18 Strand: +
Coding Region
   Position: hg19 chr9:132,816,212-132,897,400 Size: 81,189 Coding Exon Count: 18 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:132,816,185-132,902,443)mRNA (may differ from genome)Protein (552 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: GP107_HUMAN
DESCRIPTION: RecName: Full=Protein GPR107; AltName: Full=Lung seven transmembrane receptor 1; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: Belongs to the LU7TM family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 17.24 RPKM in Thyroid
Total median expression: 544.01 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -4.4027-0.163 Picture PostScript Text
3' UTR -1702.605043-0.338 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009637 - TM_rcpt_euk

Pfam Domains:
PF06814 - Lung seven transmembrane receptor
PF10192 - Rhodopsin-like GPCR transmembrane domain

SCOP Domains:
47240 - Ferritin-like

ModBase Predicted Comparative 3D Structure on Q5VW38
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details Gene Details  
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0032050 clathrin heavy chain binding

Biological Process:
GO:0072583 clathrin-dependent endocytosis

Cellular Component:
GO:0005654 nucleoplasm
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030136 clathrin-coated vesicle


-  Descriptions from all associated GenBank mRNAs
  BC039728 - Homo sapiens G protein-coupled receptor 107, mRNA (cDNA clone IMAGE:5750558), containing frame-shift errors.
BC143655 - Homo sapiens G protein-coupled receptor 107, mRNA (cDNA clone IMAGE:9052169), partial cds.
AK225456 - Homo sapiens mRNA for Splice isoform 3 of Q5VW38 variant, clone: HSI03124.
AK026244 - Homo sapiens cDNA: FLJ22591 fis, clone HSI03124.
BC030147 - Homo sapiens G protein-coupled receptor 107, mRNA (cDNA clone IMAGE:4560526), partial cds.
BC110518 - Homo sapiens G protein-coupled receptor 107, mRNA (cDNA clone MGC:126118 IMAGE:40033360), complete cds.
AF376725 - Homo sapiens lung seven transmembrane receptor 1 (LUSTR1) mRNA, complete cds.
AX776003 - Sequence 273 from Patent WO03048202.
AK293092 - Homo sapiens cDNA FLJ75421 complete cds, highly similar to Homo sapiens lung seven transmembrane receptor 1 (LUSTR1) mRNA.
AB385490 - Synthetic construct DNA, clone: pF1KA1624, Homo sapiens GPR107 gene for G-protein coupled receptor 107, complete cds, without stop codon, in Flexi system.
KJ894453 - Synthetic construct Homo sapiens clone ccsbBroadEn_03847 GPR107 gene, encodes complete protein.
AB046844 - Homo sapiens mRNA for KIAA1624 protein, partial cds.
AL834359 - Homo sapiens mRNA; cDNA DKFZp667C222 (from clone DKFZp667C222).
JD184136 - Sequence 165160 from Patent EP1572962.
JD092956 - Sequence 73980 from Patent EP1572962.
JD518641 - Sequence 499665 from Patent EP1572962.
JD227464 - Sequence 208488 from Patent EP1572962.
JD173165 - Sequence 154189 from Patent EP1572962.
JD428580 - Sequence 409604 from Patent EP1572962.
LF205634 - JP 2014500723-A/13137: Polycomb-Associated Non-Coding RNAs.
LF346691 - JP 2014500723-A/154194: Polycomb-Associated Non-Coding RNAs.
BC040059 - Homo sapiens cDNA clone IMAGE:6157729, partial cds.
AK024651 - Homo sapiens cDNA: FLJ20998 fis, clone CAE03125.
AK074380 - Homo sapiens cDNA FLJ23800 fis, clone HEP22319.
AK025836 - Homo sapiens cDNA: FLJ22183 fis, clone HRC00982.
AJ420428 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1679989.
AF308603 - Homo sapiens GCDRP mRNA, complete cds.
DQ585823 - Homo sapiens piRNA piR-52935, complete sequence.
AK021506 - Homo sapiens cDNA FLJ11444 fis, clone HEMBA1001361.
DQ570913 - Homo sapiens piRNA piR-31025, complete sequence.
BC007544 - Homo sapiens G protein-coupled receptor 107, mRNA (cDNA clone IMAGE:2959443).
AK000825 - Homo sapiens cDNA FLJ20818 fis, clone ADSE00627.
AJ420422 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 712000.
LF205635 - JP 2014500723-A/13138: Polycomb-Associated Non-Coding RNAs.
LF346692 - JP 2014500723-A/154195: Polycomb-Associated Non-Coding RNAs.
LF346693 - JP 2014500723-A/154196: Polycomb-Associated Non-Coding RNAs.
MA582268 - JP 2018138019-A/154194: Polycomb-Associated Non-Coding RNAs.
MA582269 - JP 2018138019-A/154195: Polycomb-Associated Non-Coding RNAs.
MA582270 - JP 2018138019-A/154196: Polycomb-Associated Non-Coding RNAs.
MA441211 - JP 2018138019-A/13137: Polycomb-Associated Non-Coding RNAs.
MA441212 - JP 2018138019-A/13138: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NJ53, ENST00000347136.1, ENST00000347136.10, ENST00000347136.2, ENST00000347136.3, ENST00000347136.4, ENST00000347136.5, ENST00000347136.6, ENST00000347136.7, ENST00000347136.8, ENST00000347136.9, GP107_HUMAN, KIAA1624, LUSTR1, NM_020960, Q2TB81, Q5JPA3, Q5VW38, Q5VW39, Q96T26, Q9H658, Q9HCE8, uc317xlw.1, uc317xlw.2
UCSC ID: ENST00000347136.11_6
RefSeq Accession: NM_020960.5
Protein: Q5VW38 (aka GP107_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.