ID:GPAT1_HUMAN DESCRIPTION: RecName: Full=Glycerol-3-phosphate acyltransferase 1, mitochondrial; Short=GPAT-1; EC=2.3.1.15; Flags: Precursor; FUNCTION: Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. CATALYTIC ACTIVITY: Acyl-CoA + sn-glycerol 3-phosphate = CoA + 1- acyl-sn-glycerol 3-phosphate. PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3. SUBCELLULAR LOCATION: Mitochondrion outer membrane; Multi-pass membrane protein (By similarity). DOMAIN: The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (By similarity). SIMILARITY: Belongs to the GPAT/DAPAT family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCL2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006637 acyl-CoA metabolic process GO:0006641 triglyceride metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006654 phosphatidic acid biosynthetic process GO:0008152 metabolic process GO:0008654 phospholipid biosynthetic process GO:0009749 response to glucose GO:0016024 CDP-diacylglycerol biosynthetic process GO:0019432 triglyceride biosynthetic process GO:0033146 regulation of intracellular estrogen receptor signaling pathway GO:0040018 positive regulation of multicellular organism growth GO:0042104 positive regulation of activated T cell proliferation GO:0044255 cellular lipid metabolic process GO:0045540 regulation of cholesterol biosynthetic process GO:0050707 regulation of cytokine secretion GO:0051607 defense response to virus GO:0055089 fatty acid homeostasis GO:0055091 phospholipid homeostasis GO:0070236 negative regulation of activation-induced cell death of T cells GO:0070970 interleukin-2 secretion
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
