Human Gene GP2 (ENST00000302555.10_10) from GENCODE V47lift37

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Description: glycoprotein 2, transcript variant 2 (from RefSeq NM_001502.4)
Gencode Transcript: ENST00000302555.10_10
Gencode Gene: ENSG00000169347.17_17
Transcript (Including UTRs)
Position: hg19 chr16:20,320,896-20,338,835 Size: 17,940 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr16:20,322,545-20,337,753 Size: 15,209 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr16:20,320,896-20,338,835)			mRNA (may differ from genome)		Protein (534 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: GP2_HUMAN DESCRIPTION: RecName: Full=Pancreatic secretory granule membrane major glycoprotein GP2; AltName: Full=Pancreatic zymogen granule membrane protein GP-2; AltName: Full=ZAP75; Flags: Precursor; SUBUNIT: Interacts with SYCN (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). Secreted (By similarity). Note=Secreted after cleavage in the pancreatic juice. TISSUE SPECIFICITY: Pancreatic secretory (zymogen) granule. SIMILARITY: Contains 1 EGF-like domain. SIMILARITY: Contains 1 ZP domain. CAUTION: It is uncertain whether Met-1 or Met-8 is the initiator. SEQUENCE CAUTION: Sequence=AAB19240.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GP2 Diseases sorted by gene-association score: swine influenza (22), familial juvenile hyperuricaemic nephropathy (13), lassa fever (12), ebola hemorrhagic fever (11), foodborne botulism (8), argentine hemorrhagic fever (8), alcohol-related birth defect (8)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D000111 Acetylcysteine D000643 Ammonium Chloride D001564 Benzo(a)pyrene D002737 Chloroprene D002994 Clofibrate D003042 Cocaine D004052 Diethylnitrosamine D006830 Hydralazine D014028 Tobacco Smoke Pollution more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 9286.67 RPKM in Pancreas Total median expression: 9322.09 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-25.90	83	-0.312	Picture	PostScript	Text
3' UTR	-521.30	1649	-0.316	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001507 - ZP_dom
IPR017977 - ZP_dom_CS

Pfam Domains:
PF00100 - Zona pellucida-like domain

ModBase Predicted Comparative 3D Structure on P55259


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0005576 extracellular region GO:0005886 plasma membrane GO:0016020 membrane GO:0031225 anchored component of membrane GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	BX648023 - Homo sapiens mRNA; cDNA DKFZp779K2017 (from clone DKFZp779K2017). CR749600 - Homo sapiens mRNA; cDNA DKFZp779K0533 (from clone DKFZp779K0533). BX647831 - Homo sapiens mRNA; cDNA DKFZp779J0317 (from clone DKFZp779J0317). BX648201 - Homo sapiens mRNA; cDNA DKFZp779D0242 (from clone DKFZp779D0242). BX649067 - Homo sapiens mRNA; cDNA DKFZp779J1243 (from clone DKFZp779J1243). U36221 - Human pancreatic zymogen granule membrane protein GP-2 mRNA, complete cds. BC032693 - Homo sapiens glycoprotein 2 (zymogen granule membrane), mRNA (cDNA clone MGC:45088 IMAGE:5229838), complete cds. JD447288 - Sequence 428312 from Patent EP1572962. JD147719 - Sequence 128743 from Patent EP1572962. JD324558 - Sequence 305582 from Patent EP1572962. JD307960 - Sequence 288984 from Patent EP1572962. JD435338 - Sequence 416362 from Patent EP1572962. JD404422 - Sequence 385446 from Patent EP1572962. JD404421 - Sequence 385445 from Patent EP1572962. JD522075 - Sequence 503099 from Patent EP1572962. JD151594 - Sequence 132618 from Patent EP1572962. JD307959 - Sequence 288983 from Patent EP1572962. JD435337 - Sequence 416361 from Patent EP1572962. AK293384 - Homo sapiens cDNA FLJ56017 complete cds, highly similar to Pancreatic secretory granule membrane major glycoprotein GP2 precursor. JD245645 - Sequence 226669 from Patent EP1572962. JD553891 - Sequence 534915 from Patent EP1572962. JD499585 - Sequence 480609 from Patent EP1572962. JD421869 - Sequence 402893 from Patent EP1572962. JD561805 - Sequence 542829 from Patent EP1572962. JD159994 - Sequence 141018 from Patent EP1572962. AB035541 - Homo sapiens mRNA for pancreatic zymogen granule membrane associated protein GP2 alpha form, complete cds. AB035542 - Homo sapiens mRNA for pancreatic zymogen granule membrane associated protein GP2 beta form, complete cds. D38225 - Homo sapiens mRNA for pancreatic GP2, complete cds. AK312277 - Homo sapiens cDNA, FLJ92575, Homo sapiens glycoprotein 2 (zymogen granule membrane) (GP2), mRNA. CU689488 - Synthetic construct Homo sapiens gateway clone IMAGE:100019158 5' read GP2 mRNA.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P55259 (Reactome details) participates in the following event(s): R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: A6NFM9, A6NJA8, ENST00000302555.1, ENST00000302555.2, ENST00000302555.3, ENST00000302555.4, ENST00000302555.5, ENST00000302555.6, ENST00000302555.7, ENST00000302555.8, ENST00000302555.9, GP2 , GP2_HUMAN, NM_001502, P55259, Q13338, Q9UIF1, uc317nbr.1, uc317nbr.2 UCSC ID: ENST00000302555.10_10 RefSeq Accession: NM_001502.4 Protein: P55259 (aka GP2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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