ID:GLRX3_HUMAN DESCRIPTION: RecName: Full=Glutaredoxin-3; AltName: Full=PKC-interacting cousin of thioredoxin; Short=PICOT; AltName: Full=PKC-theta-interacting protein; Short=PKCq-interacting protein; AltName: Full=Thioredoxin-like protein 2; FUNCTION: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. SUBUNIT: Monomer and homodimer; the homodimer is probably linked by 2 2Fe-2S clusters that may serve as a redox sensor. The monomer interacts with other proteins. Interacts (via N-terminus) with PRKCQ/PKC-theta. Interacts (via C-terminus) with CSRP3 (By similarity). Interacts with CSRP2 (By similarity). INTERACTION: Q04759:PRKCQ; NbExp=5; IntAct=EBI-374781, EBI-374762; SUBCELLULAR LOCATION: Cytoplasm, cell cortex. Cytoplasm, myofibril, sarcomere, Z line (By similarity). Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). TISSUE SPECIFICITY: Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine. DOMAIN: The thioredoxin domain lacks the two redox-active cysteines. This strongly suggests that it lacks thioredoxin activity. SIMILARITY: Contains 2 glutaredoxin domains. SIMILARITY: Contains 1 thioredoxin domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O76003
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002026 regulation of the force of heart contraction GO:0010614 negative regulation of cardiac muscle hypertrophy GO:0022900 electron transport chain GO:0044571 [2Fe-2S] cluster assembly GO:0045454 cell redox homeostasis GO:0055114 oxidation-reduction process GO:0097428 protein maturation by iron-sulfur cluster transfer
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
