Human Gene GDI2 (ENST00000380191.9_7) from GENCODE V47lift37

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Description: GDP dissociation inhibitor 2, transcript variant 1 (from RefSeq NM_001494.4)
Gencode Transcript: ENST00000380191.9_7
Gencode Gene: ENSG00000057608.18_16
Transcript (Including UTRs)
Position: hg19 chr10:5,807,186-5,855,397 Size: 48,212 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr10:5,807,969-5,855,221 Size: 47,253 Coding Exon Count: 11

Page Index	Sequence and Links	Primers	CTD	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr10:5,807,186-5,855,397)			mRNA (may differ from genome)		Protein (445 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C029790 2,2',3',4,4',5-hexachlorobiphenyl C021296 2-ethoxyethanol C030370 2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone D015127 9,10-Dimethyl-1,2-benzanthracene D000643 Ammonium Chloride D001564 Benzo(a)pyrene D019328 Buthionine Sulfoximine D002101 Cacodylic Acid D002330 Carmustine D002713 Chlorine D019327 Copper Sulfate D004041 Dietary Fats D005839 Gentamicins D006710 Homocysteine D008148 Lovastatin C002741 N-nitrosomorpholine D009569 Nitric Oxide D010126 Ozone D019821 Simvastatin D024483 Vitamin K 3 D014859 Warfarin C006780 bisphenol A C018021 cobaltous chloride C005219 methyl cellosolve C119536 nickel acetate C025256 nonylphenol C045950 propiconazole

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 85.94 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 1958.60 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-50.30	176	-0.286	Picture	PostScript	Text
3' UTR	-203.80	783	-0.260	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR018203 - GDP_dissociation_inhibitor
IPR000806 - RabGDI

Pfam Domains:
PF00996 - GDP dissociation inhibitor

SCOP Domains:
51905 - FAD/NAD(P)-binding domain
51971 - Nucleotide-binding domain
54373 - FAD-linked reductases, C-terminal domain

ModBase Predicted Comparative 3D Structure on Q6IAT1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details			Gene Details	Gene Details
Gene Sorter	Gene Sorter			Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005092 GDP-dissociation inhibitor activity GO:0005093 Rab GDP-dissociation inhibitor activity GO:0005096 GTPase activator activity GO:0031267 small GTPase binding Biological Process: GO:0007264 small GTPase mediated signal transduction GO:0015031 protein transport GO:0016192 vesicle-mediated transport GO:0043547 positive regulation of GTPase activity GO:0050790 regulation of catalytic activity Cellular Component: GO:0005737 cytoplasm GO:0005794 Golgi apparatus GO:0043209 myelin sheath

Descriptions from all associated GenBank mRNAs


	KJ891233 - Synthetic construct Homo sapiens clone ccsbBroadEn_00627 GDI2 gene, encodes complete protein. AK122841 - Homo sapiens cDNA FLJ16452 fis, clone BRAWH3002467, highly similar to RAB GDP DISSOCIATION INHIBITOR BETA. BX648038 - Homo sapiens mRNA; cDNA DKFZp779F1867 (from clone DKFZp779F1867). BC005145 - Homo sapiens GDP dissociation inhibitor 2, mRNA (cDNA clone MGC:2027 IMAGE:3504736), complete cds. Y13286 - Homo sapiens mRNA for GDP dissociation inhibitor beta. BC024168 - Homo sapiens, Similar to GDP dissociation inhibitor 2, clone IMAGE:4045021, mRNA, partial cds. AK094671 - Homo sapiens cDNA FLJ37352 fis, clone BRAMY2021982. JD103997 - Sequence 85021 from Patent EP1572962. JD346846 - Sequence 327870 from Patent EP1572962. JD154071 - Sequence 135095 from Patent EP1572962. JD232400 - Sequence 213424 from Patent EP1572962. JD244196 - Sequence 225220 from Patent EP1572962. JD562957 - Sequence 543981 from Patent EP1572962. AK297554 - Homo sapiens cDNA FLJ60305 complete cds, highly similar to Rab GDP dissociation inhibitor beta. JD204884 - Sequence 185908 from Patent EP1572962. JD434165 - Sequence 415189 from Patent EP1572962. AK309360 - Homo sapiens cDNA, FLJ99401. AK297177 - Homo sapiens cDNA FLJ60299 complete cds, highly similar to Rab GDP dissociation inhibitor beta. D13988 - Homo sapiens rab GDI mRNA, complete cds. AB451295 - Homo sapiens GDI2 mRNA for GDP dissociation inhibitor 2 isoform 1, complete cds, clone: FLJ08144AAAN. CR457073 - Homo sapiens full open reading frame cDNA clone RZPDo834H0511D for gene GDI2, GDP dissociation inhibitor 2; complete cds, incl. stopcodon. AK312485 - Homo sapiens cDNA, FLJ92845, Homo sapiens GDP dissociation inhibitor 2 (GDI2), mRNA. BT006868 - Homo sapiens GDP dissociation inhibitor 2 mRNA, complete cds. EU794614 - Homo sapiens epididymis secretory sperm binding protein Li 46e (HEL-S-46e) mRNA, complete cds. DQ890573 - Synthetic construct clone IMAGE:100003203; FLH164056.01X; RZPDo839C03162D GDP dissociation inhibitor 2 (GDI2) gene, encodes complete protein. DQ893733 - Synthetic construct Homo sapiens clone IMAGE:100008193; FLH164052.01L; RZPDo839C03161D GDP dissociation inhibitor 2 (GDI2) gene, encodes complete protein. AB451429 - Homo sapiens GDI2 mRNA for GDP dissociation inhibitor 2 isoform 1, partial cds, clone: FLJ08144AAAF. AF144713 - Homo sapiens Rab GDP dissociation inhibitor beta mRNA, partial cds. JD021626 - Sequence 2650 from Patent EP1572962. JD032783 - Sequence 13807 from Patent EP1572962. JD399411 - Sequence 380435 from Patent EP1572962. JD555634 - Sequence 536658 from Patent EP1572962. JD409515 - Sequence 390539 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000380191.1, ENST00000380191.2, ENST00000380191.3, ENST00000380191.4, ENST00000380191.5, ENST00000380191.6, ENST00000380191.7, ENST00000380191.8, GDI2 , hCG_24071 , HEL-S-46e , NM_001494, Q6IAT1, Q6IAT1_HUMAN, uc318plb.1, uc318plb.2 UCSC ID: ENST00000380191.9_7 RefSeq Accession: NM_001494.4 Protein: Q6IAT1

Gene Model Information


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Methods, Credits, and Use Restrictions


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