ID:G45IP_HUMAN DESCRIPTION: RecName: Full=Growth arrest and DNA damage-inducible proteins-interacting protein 1; AltName: Full=CKII beta-associating protein; AltName: Full=CR6-interacting factor 1; Short=CRIF1; AltName: Full=Papillomavirus L2-interacting nuclear protein 1; Short=PLINP; Short=PLINP-1; AltName: Full=p53-responsive gene 6 protein; FUNCTION: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. SUBUNIT: Interacts with GADD45A, GADD45B and GADD45G. Interacts with NR4A1 via the NR4A1 AB domain. Interacts with the human papilloma virus type 16 (HPV 16) minor capsid protein L2. Interacts with ATAD3A and ATAD3B. INTERACTION: P24522:GADD45A; NbExp=3; IntAct=EBI-372506, EBI-448167; P22339:Gadd45b (xeno); NbExp=3; IntAct=EBI-372506, EBI-2266938; O95257:GADD45G; NbExp=4; IntAct=EBI-372506, EBI-448202; SUBCELLULAR LOCATION: Mitochondrion. Nucleus. Note=Using N- terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). TISSUE SPECIFICITY: Widely expressed. Highly expressed in the thyroid gland, heart, lymph nodes, trachea and adrenal tissues. Expressed at lower level in liver skeletal muscle, kidney, pancreas, testis, ovary and stomach. Barely detectable in adrenal adenoma and papillary thyroid cancer. INDUCTION: Down-regulated by p53/TP53 in apoptotic cells. MISCELLANEOUS: Cells overexpressing GADD45GIP1 were more likely to be in G1 and less likely to be in S phase and grow more slowly than control cells. Inhibiting the expression of GADD45GIP1 promotes cell cycle progression.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10147 - Growth arrest and DNA-damage-inducible proteins-interacting protein 1
ModBase Predicted Comparative 3D Structure on Q8TAE8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AJ295986 - Homo sapiens mRNA for hypothetical protein (ORF1), clone Telethon(Italy_B41)_Strait01240_FL405. BC069200 - Homo sapiens growth arrest and DNA-damage-inducible, gamma interacting protein 1, mRNA (cDNA clone MGC:78462 IMAGE:5467620), complete cds. AF479749 - Homo sapiens CR6 interacting factor 1 mRNA, complete cds. BC004944 - Homo sapiens growth arrest and DNA-damage-inducible, gamma interacting protein 1, mRNA (cDNA clone IMAGE:3615328), partial cds. BC013027 - Homo sapiens growth arrest and DNA-damage-inducible, gamma interacting protein 1, mRNA (cDNA clone IMAGE:3531729), partial cds. BC013039 - Homo sapiens growth arrest and DNA-damage-inducible, gamma interacting protein 1, mRNA (cDNA clone IMAGE:3537574), partial cds. AF412816 - Homo sapiens CKII beta binding protein 2 mRNA, complete cds. AF475095 - Homo sapiens CKII beta associating protein mRNA, complete cds. JD387795 - Sequence 368819 from Patent EP1572962. JD105232 - Sequence 86256 from Patent EP1572962. AJ429498 - Homo sapiens mRNA for Papillomavirus L2 interacting nuclear protein 1 (PLINP-1 gene). HQ447517 - Synthetic construct Homo sapiens clone IMAGE:100070856; CCSB014860_01 growth arrest and DNA-damage-inducible, gamma interacting protein 1 (GADD45GIP1) gene, encodes complete protein. KJ904939 - Synthetic construct Homo sapiens clone ccsbBroadEn_14333 GADD45GIP1 gene, encodes complete protein. CU686712 - Synthetic construct Homo sapiens gateway clone IMAGE:100023104 5' read GADD45GIP1 mRNA. JD020615 - Sequence 1639 from Patent EP1572962. JD028456 - Sequence 9480 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8TAE8 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
