Human Gene GABARAP (ENST00000302386.10_7) from GENCODE V47lift37

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Description: GABA type A receptor-associated protein (from RefSeq NM_007278.2)
Gencode Transcript: ENST00000302386.10_7
Gencode Gene: ENSG00000170296.10_10
Transcript (Including UTRs)
Position: hg19 chr17:7,143,327-7,145,768 Size: 2,442 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr17:7,144,173-7,145,649 Size: 1,477 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:7,143,327-7,145,768)			mRNA (may differ from genome)		Protein (117 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q6IAW1_HUMAN DESCRIPTION: SubName: Full=GABA(A) receptor-associated protein; SubName: Full=GABARAP protein; SubName: Full=HCG1987397, isoform CRA_b; SIMILARITY: Belongs to the MAP1 LC3 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: GABARAP Diseases sorted by gene-association score: stiff-person syndrome (10), cataract 31, multiple types (8), mental retardation, x-linked, syndromic 15 (8)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D014635 Valproic Acid C025946 3-methyladenine D000643 Ammonium Chloride D001205 Ascorbic Acid D001241 Aspirin D003993 Dibutyl Phthalate D006830 Hydralazine D010795 Phthalic Acids D020849 Raloxifene D012524 Sarin more ... click here to view the complete list

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-39.00	119	-0.328	Picture	PostScript	Text
3' UTR	-264.10	846	-0.312	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004241 - Atg8_ubiquitin-like

Pfam Domains:
PF02991 - Autophagy protein Atg8 ubiquitin like
PF04110 - Ubiquitin-like autophagy protein Apg12

SCOP Domains:
54236 - Ubiquitin-like

ModBase Predicted Comparative 3D Structure on Q6IAW1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0008017 microtubule binding GO:0050811 GABA receptor binding Biological Process: GO:0000226 microtubule cytoskeleton organization GO:0006914 autophagy GO:0015031 protein transport Cellular Component: GO:0005764 lysosome GO:0005790 smooth endoplasmic reticulum GO:0005794 Golgi apparatus GO:0005875 microtubule associated complex GO:0005886 plasma membrane GO:0005930 axoneme GO:0015629 actin cytoskeleton GO:0044297 cell body GO:0048471 perinuclear region of cytoplasm GO:0097225 sperm midpiece

Descriptions from all associated GenBank mRNAs


	AB030711 - Homo sapiens FLC3B mRNA for MAP1 light chain 3 related protein, complete cds. AF067171 - Homo sapiens ganglioside expression factor 2 homolog mRNA, complete cds. AF161586 - Homo sapiens GABA-A receptor-associated protein (GABARAP) mRNA, complete cds. AK098634 - Homo sapiens cDNA FLJ25768 fis, clone TST06391, highly similar to GABA(A) receptor-associated protein. AL050182 - Homo sapiens mRNA; cDNA DKFZp586A1923 (from clone DKFZp586A1923). AF183425 - Homo sapiens HT004 protein mRNA, complete cds. AF044671 - Homo sapiens MM46 mRNA, complete cds. JD045826 - Sequence 26850 from Patent EP1572962. JD369890 - Sequence 350914 from Patent EP1572962. JD041536 - Sequence 22560 from Patent EP1572962. BC106748 - Homo sapiens GABA(A) receptor-associated protein, mRNA (cDNA clone MGC:120154 IMAGE:40022383), complete cds. BC106749 - Homo sapiens GABA(A) receptor-associated protein, mRNA (cDNA clone MGC:120155 IMAGE:40022384), complete cds. JD093266 - Sequence 74290 from Patent EP1572962. JD297609 - Sequence 278633 from Patent EP1572962. JD260924 - Sequence 241948 from Patent EP1572962. JD528816 - Sequence 509840 from Patent EP1572962. JD429506 - Sequence 410530 from Patent EP1572962. JD091068 - Sequence 72092 from Patent EP1572962. JD291377 - Sequence 272401 from Patent EP1572962. JD511865 - Sequence 492889 from Patent EP1572962. GQ891383 - Homo sapiens clone HEL-S-178n epididymis secretory sperm binding protein mRNA, complete cds. AK312205 - Homo sapiens cDNA, FLJ92494, highly similar to Homo sapiens GABA(A) receptor-associated protein (GABARAP), mRNA. KJ893285 - Synthetic construct Homo sapiens clone ccsbBroadEn_02679 GABARAP gene, encodes complete protein. CR542235 - Homo sapiens full open reading frame cDNA clone RZPDo834G0625D for gene GABARAP, GABA(A) receptor-associated protein; complete cds, without stopcodon. CR457043 - Homo sapiens full open reading frame cDNA clone RZPDo834C0515D for gene GABARAP, GABA(A) receptor-associated protein; complete cds, incl. stopcodon. JN663880 - Homo sapiens GABARAP-a (GABARAP) mRNA, complete cds, alternatively spliced. JD220975 - Sequence 201999 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_gabaPathway - Gamma-aminobutyric Acid Receptor Life Cycle

Other Names for This Gene


	Alternate Gene Symbols: ENST00000302386.1, ENST00000302386.2, ENST00000302386.3, ENST00000302386.4, ENST00000302386.5, ENST00000302386.6, ENST00000302386.7, ENST00000302386.8, ENST00000302386.9, GABARAP , hCG_1987397 , NM_007278, Q6IAW1, Q6IAW1_HUMAN, uc317nan.1, uc317nan.2 UCSC ID: ENST00000302386.10_7 RefSeq Accession: NM_007278.2 Protein: Q6IAW1

Gene Model Information


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Methods, Credits, and Use Restrictions


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