Human Gene FYN (ENST00000354650.7_10) from GENCODE V47lift37
  Description: FYN proto-oncogene, Src family tyrosine kinase, transcript variant 1 (from RefSeq NM_002037.5)
Gencode Transcript: ENST00000354650.7_10
Gencode Gene: ENSG00000010810.18_19
Transcript (Including UTRs)
   Position: hg19 chr6:111,981,535-112,194,655 Size: 213,121 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr6:111,982,942-112,041,254 Size: 58,313 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:111,981,535-112,194,655)mRNA (may differ from genome)Protein (537 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FYN_HUMAN
DESCRIPTION: RecName: Full=Tyrosine-protein kinase Fyn; EC=2.7.10.2; AltName: Full=Proto-oncogene Syn; AltName: Full=Proto-oncogene c-Fyn; AltName: Full=Src-like kinase; Short=SLK; AltName: Full=p59-Fyn;
FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta- catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essential part of the glomerular filter of the kidney) by phosphorylating several slit diaphragm components including NPHS1, KIRREL and TRPC6. Plays a role in neural processes by phosphorylating DPYSL2, a multifunctional adapter protein within the central nervous system, ARHGAP32, a regulator for Rho family GTPases implicated in various neural functions, and SNCA, a small pre-synaptic protein. Participates in the downstream signaling pathways that lead to T-cell differentiation and proliferation following T-cell receptor (TCR) stimulation. Also participates in negative feedback regulation of TCR signaling through phosphorylation of PAG1, thereby promoting interaction between PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains LCK and FYN in an inactive form. Promotes CD28-induced phosphorylation of VAV1.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
COFACTOR: Manganese.
ENZYME REGULATION: Inhibited by phosphorylation of Tyr-531 by leukocyte common antigen and activated by dephosphorylation of this site.
SUBUNIT: Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts (via its SH3 domain) with HEV ORF3 protein. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway.
INTERACTION: O92972:- (xeno); NbExp=2; IntAct=EBI-515315, EBI-710506; P27958:- (xeno); NbExp=4; IntAct=EBI-515315, EBI-706378; Q9WMX2:- (xeno); NbExp=2; IntAct=EBI-515315, EBI-710918; P42684:ABL2; NbExp=2; IntAct=EBI-515315, EBI-1102694; A7KAX9:ARHGAP32; NbExp=4; IntAct=EBI-515315, EBI-308663; O14559:ARHGAP33; NbExp=2; IntAct=EBI-515315, EBI-1210010; Q9ULH1:ASAP1; NbExp=2; IntAct=EBI-515315, EBI-346622; Q8WX92:COBRA1; NbExp=2; IntAct=EBI-515315, EBI-347721; P50406:HTR6; NbExp=7; IntAct=EBI-515315, EBI-1182222; Q07666:KHDRBS1; NbExp=3; IntAct=EBI-515315, EBI-1364; Q92918:MAP4K1; NbExp=2; IntAct=EBI-515315, EBI-881; Q9H204:MED28; NbExp=5; IntAct=EBI-515315, EBI-514199; O43900:PRICKLE3; NbExp=2; IntAct=EBI-515315, EBI-1751761; Q05655:PRKCD; NbExp=4; IntAct=EBI-515315, EBI-704279; Q04759:PRKCQ; NbExp=7; IntAct=EBI-515315, EBI-374762; Q13905:RAPGEF1; NbExp=2; IntAct=EBI-515315, EBI-976876;
SUBCELLULAR LOCATION: Cell membrane. Note=Present and active in lipid rafts. Palmitoylation is crucial for proper trafficking.
TISSUE SPECIFICITY: Isoform 1 is highly expressed in the brain. Isoform 2 is expressed in cells of hemopoietic lineages, especially T-lymphocytes.
PTM: Autophosphorylated at Tyr-420. Phosphorylation on the C- terminal tail at Tyr-531 by CSK maintains the enzyme in an inactive state (By similarity). PTPRC/CD45 dephosphorylates Tyr- 531 leading to activation.
PTM: Palmitoylation at Cys-3 and Cys-6 regulates subcellular location (By similarity).
SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
SIMILARITY: Contains 1 protein kinase domain.
SIMILARITY: Contains 1 SH2 domain.
SIMILARITY: Contains 1 SH3 domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FYN
Diseases sorted by gene-association score: wiskott-aldrich syndrome (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 30.23 RPKM in Brain - Amygdala
Total median expression: 784.38 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -315.30607-0.519 Picture PostScript Text
3' UTR -310.901407-0.221 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR001245 - Ser-Thr/Tyr_kinase_cat_dom
IPR000980 - SH2
IPR001452 - SH3_domain
IPR008266 - Tyr_kinase_AS
IPR020635 - Tyr_kinase_cat_dom

Pfam Domains:
PF00017 - SH2 domain
PF00018 - SH3 domain
PF00069 - Protein kinase domain
PF07653 - Variant SH3 domain
PF07714 - Protein tyrosine and serine/threonine kinase
PF14604 - Variant SH3 domain

SCOP Domains:
50044 - SH3-domain
56112 - Protein kinase-like (PK-like)
55550 - SH2 domain

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1A0N - NMR MuPIT 1AOT - NMR MuPIT 1AOU - NMR MuPIT 1AVZ - X-ray MuPIT 1AZG - NMR MuPIT 1EFN - X-ray 1FYN - X-ray MuPIT 1G83 - X-ray MuPIT 1M27 - X-ray MuPIT 1NYF - NMR MuPIT 1NYG - NMR MuPIT 1SHF - X-ray MuPIT 1ZBJ - NMR MuPIT 2DQ7 - X-ray MuPIT 3H0F - X-ray MuPIT 3H0H - X-ray MuPIT 3H0I - X-ray MuPIT 3UA6 - X-ray MuPIT 3UA7 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P06241
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0001664 G-protein coupled receptor binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015631 tubulin binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0031802 type 5 metabotropic glutamate receptor binding
GO:0042608 T cell receptor binding
GO:0042609 CD4 receptor binding
GO:0042610 CD8 receptor binding
GO:0042802 identical protein binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0044325 ion channel binding
GO:0044877 macromolecular complex binding
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity
GO:0048156 tau protein binding
GO:0051428 peptide hormone receptor binding
GO:0070851 growth factor receptor binding
GO:0097718 disordered domain specific binding

Biological Process:
GO:0000165 MAPK cascade
GO:0001764 neuron migration
GO:0002223 stimulatory C-type lectin receptor signaling pathway
GO:0002250 adaptive immune response
GO:0002376 immune system process
GO:0006468 protein phosphorylation
GO:0006816 calcium ion transport
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007596 blood coagulation
GO:0007612 learning
GO:0007631 feeding behavior
GO:0008360 regulation of cell shape
GO:0010629 negative regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0030900 forebrain development
GO:0031295 T cell costimulation
GO:0031397 negative regulation of protein ubiquitination
GO:0035556 intracellular signal transduction
GO:0036120 cellular response to platelet-derived growth factor stimulus
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0042110 T cell activation
GO:0042127 regulation of cell proliferation
GO:0042177 negative regulation of protein catabolic process
GO:0042493 response to drug
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein
GO:0042981 regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0046777 protein autophosphorylation
GO:0046854 phosphatidylinositol phosphorylation
GO:0048010 vascular endothelial growth factor receptor signaling pathway
GO:0048013 ephrin receptor signaling pathway
GO:0048813 dendrite morphogenesis
GO:0050690 regulation of defense response to virus by virus
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050798 activated T cell proliferation
GO:0050852 T cell receptor signaling pathway
GO:0050900 leukocyte migration
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051897 positive regulation of protein kinase B signaling
GO:0071363 cellular response to growth factor stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090314 positive regulation of protein targeting to membrane
GO:0097062 dendritic spine maintenance
GO:1900182 positive regulation of protein localization to nucleus
GO:1900449 regulation of glutamate receptor signaling pathway
GO:1901216 positive regulation of neuron death
GO:1902951 negative regulation of dendritic spine maintenance
GO:1903997 positive regulation of non-membrane spanning protein tyrosine kinase activity
GO:1904645 response to beta-amyloid
GO:1905232 cellular response to L-glutamate
GO:1905430 cellular response to glycine
GO:1905477 positive regulation of protein localization to membrane
GO:1905664 regulation of calcium ion import across plasma membrane
GO:2001056 positive regulation of cysteine-type endopeptidase activity
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005768 endosome
GO:0005829 cytosol
GO:0005884 actin filament
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0030425 dendrite
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0071944 cell periphery


-  Descriptions from all associated GenBank mRNAs
  BC032496 - Homo sapiens FYN oncogene related to SRC, FGR, YES, mRNA (cDNA clone MGC:45350 IMAGE:5219761), complete cds.
M14676 - Human src-like kinase (slk) mRNA, complete cds.
M14333 - Homo sapiens c-syn protooncogene mRNA, complete cds.
AK056699 - Homo sapiens cDNA FLJ32137 fis, clone PEBLM2000479, highly similar to Proto-oncogene tyrosine-protein kinase Fyn (EC 2.7.10.2).
BX537571 - Homo sapiens mRNA; cDNA DKFZp686E249 (from clone DKFZp686E249).
JD307334 - Sequence 288358 from Patent EP1572962.
JD520181 - Sequence 501205 from Patent EP1572962.
JD225575 - Sequence 206599 from Patent EP1572962.
AB451293 - Homo sapiens FYN mRNA for protein-tyrosine kinase fyn isoform a, complete cds, clone: FLJ08138AAAN.
S74774 - p59fyn(T)=OKT3-induced calcium influx regulator [human, Jurkat J6 T cell line, mRNA Partial, 1605 nt].
JF432194 - Synthetic construct Homo sapiens clone IMAGE:100073356 FYN oncogene related to SRC, FGR, YES (FYN) gene, encodes complete protein.
KJ891206 - Synthetic construct Homo sapiens clone ccsbBroadEn_00600 FYN gene, encodes complete protein.
AB451426 - Homo sapiens FYN mRNA for protein-tyrosine kinase fyn isoform a, partial cds, clone: FLJ08138AAAF.
AB528738 - Synthetic construct DNA, clone: pF1KB9955, Homo sapiens FYN gene for FYN oncogene related to SRC, FGR, YES, without stop codon, in Flexi system.
AY429536 - Homo sapiens FYNv_2 mRNA sequence; alternatively spliced.
CU689398 - Synthetic construct Homo sapiens gateway clone IMAGE:100019609 5' read FYN mRNA.
JD037937 - Sequence 18961 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_biopeptidesPathway - Bioactive Peptide Induced Signaling Pathway
h_integrinPathway - Integrin Signaling Pathway
h_ephA4Pathway - Eph Kinases and ephrins support platelet aggregation
h_tsp1Pathway - TSP-1 Induced Apoptosis in Microvascular Endothelial Cell
h_il7Pathway - IL-7 Signal Transduction
h_tcrPathway - T Cell Receptor Signaling Pathway
h_tcraPathway - Lck and Fyn tyrosine kinases in initiation of TCR Activation
h_ecmPathway - Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
h_reelinPathway - Reelin Signaling Pathway

Reactome (by CSHL, EBI, and GO)

Protein P06241 (Reactome details) participates in the following event(s):

R-HSA-200908 Nef Binds and activates the Src-family tyrosine kinase Fyn
R-HSA-432295 GPVI binds Fyn and Lyn
R-HSA-5218824 p-6Y-VEGFR2 binds FYN
R-HSA-8981534 Nephrin dimer:KIRREL binds FYN
R-HSA-391867 Fyn binds NCAM1
R-HSA-373724 Nephrin binds NCK
R-HSA-373727 Nephrin binds CD2AP
R-HSA-373734 Nephrin interacts with Podocin
R-HSA-373747 Phosphorylation of nephrin by FYN
R-HSA-399942 Plexin-A1-4 binds NRP1
R-HSA-114577 Binding of GPVI:Fc Epsilon R1 gamma receptor complex with collagen
R-HSA-5218806 FYN autophosphorylates
R-HSA-205205 Interaction of Src family kinases with p-KIT
R-HSA-388833 Phosphorylation of CTLA-4
R-HSA-388831 Phosphorylation of CD28
R-HSA-418868 Recruitment of Src and Fyn to DCC:FADK1
R-HSA-3928615 EFNBs bind SFKs
R-HSA-879917 CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
R-HSA-2395439 Phosphorylation of DAP12
R-HSA-3928584 p-EPHs bind SRC,FYN,YES,LYN
R-HSA-389354 Activation of Vav1
R-HSA-8855237 FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1
R-HSA-391868 Dephosphorylation of NCAM1 bound pFyn
R-HSA-5218854 p-Y420-FYN is phosphorylated on S21
R-HSA-5218847 PAK2 binds NCK
R-HSA-532603 Nephrin mediated activation of N-WASP
R-HSA-451758 p85 associates with both p-Nephrin and CD2AP
R-HSA-391871 Autophosphorylation of NCAM1 bound Fyn
R-HSA-399934 Phosphorylation of Plexin-A
R-HSA-399933 Sema3A binds Nrp-1 bound to PlexinA
R-HSA-399931 Activation of Fyn
R-HSA-114600 Fyn/Lyn-mediated phosphorylation of FcR1 gamma
R-HSA-139842 Binding of Syk tyrosine kinase
R-HSA-453183 p-Y348-SYK dissociates
R-HSA-205238 SHP2 interacts with p-KIT
R-HSA-205319 Interaction of APS and p-KIT
R-HSA-1433451 JAK2 binds to p-KIT
R-HSA-1472121 Phosphorylation of p-KIT on Y900 by Src kinases
R-HSA-388829 SHP2 phosphatase binds CTLA-4
R-HSA-210291 Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src
R-HSA-388814 Grb2 binds CD28
R-HSA-388832 PI3K binds CD28
R-HSA-389381 Gads binds CD28
R-HSA-373716 DCC interacting NCK-1
R-HSA-374701 Phosphorylation of DCC by Fyn
R-HSA-3928639 p-EFNB binds GRB4
R-HSA-3928580 SFKs phosphorylate EFNBs
R-HSA-912629 CBL is tyrosine phosphorylated
R-HSA-210289 Recruitment of SYK to p-DAP12
R-HSA-3928623 EPHBs bind NMDARs
R-HSA-3928607 p-EPHs bind VAV2,3
R-HSA-3928602 NGEF binds EPHA
R-HSA-4093327 EPHA binds TIAM1
R-HSA-5621355 LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG
R-HSA-391865 Recruitment of FAK to NCAM1:Fyn in lipid rafts
R-HSA-2730860 Phosphorylation of GAB2 by SYK/FYN
R-HSA-1963586 SRC family kinases phosphorylate ERBB2
R-HSA-5218832 CDC42:GTP binds PAK2
R-HSA-5218814 PAK2 autophorylates
R-HSA-5218812 FYN phosphorylates PAK2
R-HSA-399946 Recruitment and activation of Cdk5
R-HSA-399941 Rac1 binds PlexinA
R-HSA-399947 Tyrosine phosphorylation of CRMPs by Fes
R-HSA-453200 SYK autophosphorylates
R-HSA-1433506 Phosphorylation of APS
R-HSA-1433488 Phosphorylation of SHP2 by SFKs
R-HSA-1433418 Phosphorylation of JAK2
R-HSA-1433456 Recruitment of STATs
R-HSA-1433428 GRB2 is indirectly recruited to p-KIT through SHP2
R-HSA-1470012 Disassociation and translocation of STATs to the nucleus
R-HSA-1470010 Dimerization of STATs
R-HSA-1433542 Phosphorylation and activation of VAV1
R-HSA-389352 Translocation of Vav1 to CD28
R-HSA-418858 RhoGTPase GEF's recruited to DCC
R-HSA-418859 Phosphorylation of Unc5C
R-HSA-418863 Shp2 binds pUnc5C
R-HSA-3928614 EFNB:GRB4 binds GIT1
R-HSA-3928594 SFKs phosphorylate GIT1
R-HSA-2395412 Phosphorylation of SYK
R-HSA-2424482 p85 regulatory unit of PI3K binds p-6Y-SYK
R-HSA-3928645 EPHB:NMDAR binds TIAM1
R-HSA-3928583 FYN phosphorylates NMDAR2B
R-HSA-3928604 SFKs phosphorylate VAV2,3
R-HSA-3928648 SFKs phosphorylate NGEF
R-HSA-391866 Phosphorylation of FAK by Src kinase
R-HSA-392051 Recruitment of Grb2 to pFAK:NCAM1
R-HSA-392053 SOS binds Grb2 bound to pFAK:NCAM1
R-HSA-399951 Phosphorylation of CRMPs by GSK3beta
R-HSA-399944 Phosphorylation of CRMPs by Cdk5
R-HSA-399928 Recruitment of Rnd1 to Plexin A
R-HSA-399930 Activation of PAK by Rac1
R-HSA-205244 Recruitment of CBL to KIT
R-HSA-205234 Indirect recruitment of GAB2 to p-KIT
R-HSA-389158 CD28 bound PI3K phosphorylates PIP2 to PIP3
R-HSA-418850 Activation of Cdc42
R-HSA-418856 Activation of Rac1
R-HSA-3928631 GIT1 binds bPIX
R-HSA-2395801 Phosphorylation of LAT by p-SYK
R-HSA-2396594 Phosphorylation of SLP-76 by p-SYK
R-HSA-2424484 Phosphorylation of BTK by p-SYK
R-HSA-2424486 Phosphorylation and activation of VAV2/VAV3 by SYK
R-HSA-2424480 PI3K phosphorylates PIP2 to PIP3
R-HSA-3928627 EPHB phosphorylates TIAM1
R-HSA-3928628 VAV exchanges GTP for GDP on RAC1, activating it
R-HSA-3928642 TIAM1 exchanges GTP for GDP on RAC1, activating it
R-HSA-3928651 NGEF exchanges GTP for GDP on RHOA
R-HSA-392054 NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras
R-HSA-399939 Autophosphorylation of PAK
R-HSA-1562641 Indirect recruitment of PI3K to KIT via p(Y)-GAB2
R-HSA-2400009 PI3K inhibitors block PI3K catalytic activity
R-HSA-2316434 PI3K phosphorylates PIP2 to PIP3
R-HSA-389348 Activation of Rac1 by pVav1
R-HSA-389350 Activation of Cdc42 by pVav1
R-HSA-418874 Recruitment and activation of N-WASP by Cdc42
R-HSA-418865 Recruitment of ABLIM to the plasma membrane
R-HSA-3928633 bPIX exchanges GTP for GDP on RAC, activating it
R-HSA-2424487 Phosphorylation of PLC-gamma by p-BTK/p-SYK
R-HSA-4093336 p-TIAM1 exchanges GTP for GDP on RAC1, activating it
R-HSA-5672965 RAS GEFs promote RAS nucleotide exchange
R-HSA-399952 Phosphorylation of LIMK-1 by PAK
R-HSA-399935 Inactivation of R-Ras by Sema3A-Plexin-A GAP activity
R-HSA-3928641 PAK binds RAC and bPIX
R-HSA-1433514 Synthesis of PIP3 from PIP2 by PI3K
R-HSA-3928625 PAKs autophosphorylate
R-HSA-3928640 PAKs phosphorylate MLC
R-HSA-164944 Nef and signal transduction
R-HSA-75892 Platelet Adhesion to exposed collagen
R-HSA-4420097 VEGFA-VEGFR2 Pathway
R-HSA-373753 Nephrin family interactions
R-HSA-375165 NCAM signaling for neurite out-growth
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-389513 CTLA4 inhibitory signaling
R-HSA-389356 CD28 co-stimulation
R-HSA-418885 DCC mediated attractive signaling
R-HSA-3928664 Ephrin signaling
R-HSA-912631 Regulation of signaling by CBL
R-HSA-2424491 DAP12 signaling
R-HSA-2682334 EPH-Ephrin signaling
R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis
R-HSA-109582 Hemostasis
R-HSA-194138 Signaling by VEGF
R-HSA-1500931 Cell-Cell communication
R-HSA-389359 CD28 dependent Vav1 pathway
R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
R-HSA-8866376 Reelin signalling pathway
R-HSA-422475 Axon guidance
R-HSA-373755 Semaphorin interactions
R-HSA-399956 CRMPs in Sema3A signaling
R-HSA-114604 GPVI-mediated activation cascade
R-HSA-1433559 Regulation of KIT signaling
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-388841 Costimulation by the CD28 family
R-HSA-210990 PECAM1 interactions
R-HSA-389357 CD28 dependent PI3K/Akt signaling
R-HSA-373752 Netrin-1 signaling
R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling
R-HSA-2029481 FCGR activation
R-HSA-2172127 DAP12 interactions
R-HSA-3928662 EPHB-mediated forward signaling
R-HSA-3928665 EPH-ephrin mediated repulsion of cells
R-HSA-3928663 EPHA-mediated growth cone collapse
R-HSA-5621480 Dectin-2 family
R-HSA-5621575 CD209 (DC-SIGN) signaling
R-HSA-162909 Host Interactions of HIV factors
R-HSA-983705 Signaling by the B Cell Receptor (BCR)
R-HSA-1266738 Developmental Biology
R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-1227986 Signaling by ERBB2
R-HSA-76002 Platelet activation, signaling and aggregation
R-HSA-162582 Signal Transduction
R-HSA-1280218 Adaptive Immune System
R-HSA-418886 Netrin mediated repulsion signals
R-HSA-449147 Signaling by Interleukins
R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-168249 Innate Immune System
R-HSA-5621481 C-type lectin receptors (CLRs)
R-HSA-162906 HIV Infection
R-HSA-2454202 Fc epsilon receptor (FCERI) signaling
R-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-168256 Immune System
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-5663205 Infectious disease
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1643685 Disease
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-2219528 PI3K/AKT Signaling in Cancer
R-HSA-9006925 Intracellular signaling by second messengers
R-HSA-199418 Negative regulation of the PI3K/AKT network
R-HSA-5684996 MAPK1/MAPK3 signaling
R-HSA-5663202 Diseases of signal transduction
R-HSA-5683057 MAPK family signaling cascades
R-HSA-9032502 Activated NTRK2 binds FYN
R-HSA-9037040 SRC,FYN phosphorylate NTRK2
R-HSA-9032500 Activated NTRK2 signals through FYN
R-HSA-9006115 Signaling by NTRK2 (TRKB)
R-HSA-9032759 NTRK2 activates RAC1
R-HSA-166520 Signaling by NTRKs
R-HSA-9006934 Signaling by Receptor Tyrosine Kinases
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B5BU57, E1P557, ENST00000354650.1, ENST00000354650.2, ENST00000354650.3, ENST00000354650.4, ENST00000354650.5, ENST00000354650.6, FYN_HUMAN, H0UI48, NM_002037, P06241, Q16248, Q5R3A6, Q5R3A7, Q8N5D7, uc317yst.1, uc317yst.2
UCSC ID: ENST00000354650.7_10
RefSeq Accession: NM_002037.5
Protein: P06241 (aka FYN_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.