Human Gene FOXRED2 (ENST00000397224.9_7) from GENCODE V47lift37

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Description: FAD dependent oxidoreductase domain containing 2, transcript variant 2 (from RefSeq NM_001102371.2)
Gencode Transcript: ENST00000397224.9_7
Gencode Gene: ENSG00000100350.16_12
Transcript (Including UTRs)
Position: hg19 chr22:36,883,237-36,903,087 Size: 19,851 Total Exon Count: 9 Strand: -
Coding Region
Position: hg19 chr22:36,886,055-36,902,469 Size: 16,415 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr22:36,883,237-36,903,087)			mRNA (may differ from genome)		Protein (684 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: FXRD2_HUMAN DESCRIPTION: RecName: Full=FAD-dependent oxidoreductase domain-containing protein 2; AltName: Full=Endoplasmic reticulum flavoprotein associated with degradation; Flags: Precursor; FUNCTION: Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation. COFACTOR: FAD. SUBUNIT: Interacts with SEL1L. May interact with OS9 and DNAJC10. SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. PTM: N-glycosylated. SIMILARITY: Belongs to the FOXRED2 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003300 Copper D019327 Copper Sulfate D003375 Coumestrol D005620 Freund's Adjuvant D007854 Lead C558013 NSC 689534 D018038 Sodium Selenite C006632 arsenic trioxide C044887 beta-methylcholine C069837 fullerene C60 more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 8.53 RPKM in Brain - Frontal Cortex (BA9) Total median expression: 182.95 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-10.90	33	-0.330	Picture	PostScript	Text
3' UTR	-1082.40	2818	-0.384	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

Pfam Domains:
PF07992 - Pyridine nucleotide-disulphide oxidoreductase
PF13450 - NAD(P)-binding Rossmann-like domain
PF13738 - Pyridine nucleotide-disulphide oxidoreductase

SCOP Domains:
82544 - GckA/TtuD-like
51735 - NAD(P)-binding Rossmann-fold domains
51905 - FAD/NAD(P)-binding domain
52440 - PreATP-grasp domain
51971 - Nucleotide-binding domain
51984 - MurCD N-terminal domain
53613 - Ribokinase-like
53850 - Periplasmic binding protein-like II
55248 - PCD-like

ModBase Predicted Comparative 3D Structure on Q8IWF2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0050660 flavin adenine dinucleotide binding Biological Process: GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0055114 oxidation-reduction process Cellular Component: GO:0005783 endoplasmic reticulum GO:0005788 endoplasmic reticulum lumen

Descriptions from all associated GenBank mRNAs


	JD330801 - Sequence 311825 from Patent EP1572962. JD242625 - Sequence 223649 from Patent EP1572962. BC027716 - Homo sapiens FAD-dependent oxidoreductase domain containing 2, mRNA (cDNA clone MGC:16700 IMAGE:4127473), complete cds. JD446964 - Sequence 427988 from Patent EP1572962. JD205613 - Sequence 186637 from Patent EP1572962. JD540535 - Sequence 521559 from Patent EP1572962. JD277903 - Sequence 258927 from Patent EP1572962. JD421238 - Sequence 402262 from Patent EP1572962. JD094172 - Sequence 75196 from Patent EP1572962. JD379781 - Sequence 360805 from Patent EP1572962. JD179265 - Sequence 160289 from Patent EP1572962. JD239095 - Sequence 220119 from Patent EP1572962. AK091053 - Homo sapiens cDNA FLJ33734 fis, clone BRAWH2018282, moderately similar to Thioredoxin, mitochondrial. JD405483 - Sequence 386507 from Patent EP1572962. JD461425 - Sequence 442449 from Patent EP1572962. JD537924 - Sequence 518948 from Patent EP1572962. JD447872 - Sequence 428896 from Patent EP1572962. JD267469 - Sequence 248493 from Patent EP1572962. JD112726 - Sequence 93750 from Patent EP1572962. JD052975 - Sequence 33999 from Patent EP1572962. JD258432 - Sequence 239456 from Patent EP1572962. JD376753 - Sequence 357777 from Patent EP1572962. BC015726 - Homo sapiens FAD-dependent oxidoreductase domain containing 2, mRNA (cDNA clone MGC:22928 IMAGE:4866761), complete cds. BC040351 - Homo sapiens FAD-dependent oxidoreductase domain containing 2, mRNA (cDNA clone MGC:21496 IMAGE:3873448), complete cds. JD092250 - Sequence 73274 from Patent EP1572962. JD243429 - Sequence 224453 from Patent EP1572962. JD500380 - Sequence 481404 from Patent EP1572962. AK025714 - Homo sapiens cDNA: FLJ22061 fis, clone HEP10105. AK026975 - Homo sapiens cDNA: FLJ23322 fis, clone HEP12410. JD152486 - Sequence 133510 from Patent EP1572962. JD161866 - Sequence 142890 from Patent EP1572962. JD521000 - Sequence 502024 from Patent EP1572962. JD198711 - Sequence 179735 from Patent EP1572962. JD287693 - Sequence 268717 from Patent EP1572962. JD452876 - Sequence 433900 from Patent EP1572962. JD184817 - Sequence 165841 from Patent EP1572962. JD155439 - Sequence 136463 from Patent EP1572962. JD226504 - Sequence 207528 from Patent EP1572962. JD439584 - Sequence 420608 from Patent EP1572962. JD117829 - Sequence 98853 from Patent EP1572962. JD541375 - Sequence 522399 from Patent EP1572962. JD150271 - Sequence 131295 from Patent EP1572962. JD521452 - Sequence 502476 from Patent EP1572962. JD191363 - Sequence 172387 from Patent EP1572962. JD126155 - Sequence 107179 from Patent EP1572962. AK225347 - Homo sapiens mRNA for hypothetical protein LOC80020 variant, clone: HEP10105. JD269968 - Sequence 250992 from Patent EP1572962. JD170545 - Sequence 151569 from Patent EP1572962. JD188536 - Sequence 169560 from Patent EP1572962. JD394041 - Sequence 375065 from Patent EP1572962. CR456444 - Homo sapiens dJ1119A7.3 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.dJ1119A7.3). JD360814 - Sequence 341838 from Patent EP1572962. CU013042 - Homo sapiens dJ1119A7.C22.3, mRNA (cDNA clone IMAGE:100000300), complete cds, with stop codon, in Gateway system. KJ906328 - Synthetic construct Homo sapiens clone ccsbBroadEn_15998 FOXRED2 gene, encodes complete protein. AK315555 - Homo sapiens cDNA, FLJ96626. KJ894773 - Synthetic construct Homo sapiens clone ccsbBroadEn_04167 FOXRED2 gene, encodes complete protein. AB527146 - Synthetic construct DNA, clone: pF1KE0341, Homo sapiens FOXRED2 gene for FAD-dependent oxidoreductase domain containing 2, without stop codon, in Flexi system. CU013330 - Homo sapiens dJ1119A7.C22.3, mRNA (cDNA clone IMAGE:100000204), complete cds, without stop codon, in Gateway system. CU691858 - Synthetic construct Homo sapiens gateway clone IMAGE:100017453 5' read FOXRED2 mRNA.

Other Names for This Gene


	Alternate Gene Symbols: B2RDI4, ENST00000397224.1, ENST00000397224.2, ENST00000397224.3, ENST00000397224.4, ENST00000397224.5, ENST00000397224.6, ENST00000397224.7, ENST00000397224.8, ERFAD , FOXRED2 , FXRD2_HUMAN, NM_001102371, Q8IWF2, Q8N378, Q96BD1, Q9H5L5, Q9H6M8, uc318yvo.1, uc318yvo.2 UCSC ID: ENST00000397224.9_7 RefSeq Accession: NM_001102371.2 Protein: Q8IWF2 (aka FXRD2_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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