Human Gene FKBP15 (ENST00000238256.8_9) from GENCODE V47lift37
  Description: FKBP prolyl isomerase family member 15 (from RefSeq NM_015258.2)
Gencode Transcript: ENST00000238256.8_9
Gencode Gene: ENSG00000119321.10_15
Transcript (Including UTRs)
   Position: hg19 chr9:115,923,286-115,983,557 Size: 60,272 Total Exon Count: 28 Strand: -
Coding Region
   Position: hg19 chr9:115,928,358-115,983,523 Size: 55,166 Coding Exon Count: 28 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr9:115,923,286-115,983,557)mRNA (may differ from genome)Protein (1219 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FKB15_HUMAN
DESCRIPTION: RecName: Full=FK506-binding protein 15; Short=FKBP-15; AltName: Full=133 kDa FK506-binding protein; Short=133 kDa FKBP; Short=FKBP-133; AltName: Full=WASP and FKBP-like; Short=WAFL;
FUNCTION: May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement.
SUBUNIT: Interacts with WIP and actin.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Cell projection, axon (By similarity). Early endosome. Note=Present in axons and neuronal growth cones (By similarity).
DOMAIN: The PPIase FKBP-type domain seems to be inactive both for FK506-binding and enzymatic activity (By similarity).
DOMAIN: The central coiled-coil region is responsible for association with early endosomes.
SIMILARITY: Belongs to the FKBP-type PPIase family.
SIMILARITY: Contains 1 PPIase FKBP-type domain.
SEQUENCE CAUTION: Sequence=AAH09609.1; Type=Erroneous initiation; Sequence=BAA31649.1; Type=Erroneous initiation; Sequence=CAI10963.1; Type=Erroneous initiation; Sequence=CAI10964.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 14.62 RPKM in Spleen
Total median expression: 367.56 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -5.9034-0.174 Picture PostScript Text
3' UTR -1652.305072-0.326 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001179 - PPIase_FKBP_dom

Pfam Domains:
PF00254 - FKBP-type peptidyl-prolyl cis-trans isomerase

SCOP Domains:
50729 - PH domain-like
54534 - FKBP-like

ModBase Predicted Comparative 3D Structure on Q5T1M5
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003779 actin binding
GO:0005515 protein binding

Biological Process:
GO:0006897 endocytosis
GO:0010923 negative regulation of phosphatase activity

Cellular Component:
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005884 actin filament
GO:0016020 membrane
GO:0030424 axon
GO:0030426 growth cone
GO:0042995 cell projection


-  Descriptions from all associated GenBank mRNAs
  AK307507 - Homo sapiens cDNA, FLJ97455.
CU693181 - Synthetic construct Homo sapiens gateway clone IMAGE:100022039 3' read SLC31A2 mRNA.
CR749681 - Homo sapiens mRNA; cDNA DKFZp547C072 (from clone DKFZp547C072).
DQ597312 - Homo sapiens piRNA piR-35378, complete sequence.
DQ570731 - Homo sapiens piRNA piR-30843, complete sequence.
BC026048 - Homo sapiens cDNA clone IMAGE:4900475.
BC077732 - Homo sapiens FK506 binding protein 15, 133kDa, mRNA (cDNA clone IMAGE:6292230), partial cds.
AB014574 - Homo sapiens KIAA0674 mRNA for KIAA0674 protein.
JD503065 - Sequence 484089 from Patent EP1572962.
JD218220 - Sequence 199244 from Patent EP1572962.
AK301208 - Homo sapiens cDNA FLJ57617 complete cds.
JD254221 - Sequence 235245 from Patent EP1572962.
BC131730 - Homo sapiens cDNA clone IMAGE:40124453.
JD248165 - Sequence 229189 from Patent EP1572962.
JD254368 - Sequence 235392 from Patent EP1572962.
JD330469 - Sequence 311493 from Patent EP1572962.
JD256138 - Sequence 237162 from Patent EP1572962.
JD246557 - Sequence 227581 from Patent EP1572962.
JD334899 - Sequence 315923 from Patent EP1572962.
JD054650 - Sequence 35674 from Patent EP1572962.
JD443123 - Sequence 424147 from Patent EP1572962.
JD189574 - Sequence 170598 from Patent EP1572962.
JD526901 - Sequence 507925 from Patent EP1572962.
JD053898 - Sequence 34922 from Patent EP1572962.
JD094013 - Sequence 75037 from Patent EP1572962.
BC166677 - Synthetic construct Homo sapiens clone IMAGE:100066403, MGC:195540 FK506 binding protein 15, 133kDa (FKBP15) mRNA, encodes complete protein.
AB385371 - Synthetic construct DNA, clone: pF1KA0674, Homo sapiens FKBP15 gene for FK506 binding protein 15, complete cds, without stop codon, in Flexi system.
AK303074 - Homo sapiens cDNA FLJ57682 partial cds.
AK307498 - Homo sapiens cDNA, FLJ97446.
BC009609 - Homo sapiens FK506 binding protein 15, 133kDa, mRNA (cDNA clone IMAGE:4294322), partial cds.
JD288864 - Sequence 269888 from Patent EP1572962.
JD283680 - Sequence 264704 from Patent EP1572962.
JD531178 - Sequence 512202 from Patent EP1572962.
JD129408 - Sequence 110432 from Patent EP1572962.
JD233601 - Sequence 214625 from Patent EP1572962.
JD488718 - Sequence 469742 from Patent EP1572962.
JD279429 - Sequence 260453 from Patent EP1572962.
JD256059 - Sequence 237083 from Patent EP1572962.
JD461012 - Sequence 442036 from Patent EP1572962.
JD076958 - Sequence 57982 from Patent EP1572962.
JD304010 - Sequence 285034 from Patent EP1572962.
JD476509 - Sequence 457533 from Patent EP1572962.
JD081510 - Sequence 62534 from Patent EP1572962.
JD273905 - Sequence 254929 from Patent EP1572962.
JD103631 - Sequence 84655 from Patent EP1572962.
JD264236 - Sequence 245260 from Patent EP1572962.
JD088696 - Sequence 69720 from Patent EP1572962.
JD319027 - Sequence 300051 from Patent EP1572962.
JD115622 - Sequence 96646 from Patent EP1572962.
JD374800 - Sequence 355824 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000238256.1, ENST00000238256.2, ENST00000238256.3, ENST00000238256.4, ENST00000238256.5, ENST00000238256.6, ENST00000238256.7, FKB15_HUMAN, KIAA0674, NM_015258, Q05DK8, Q5T1M2, Q5T1M5, Q6DD85, Q9Y4D0, uc317edq.1, uc317edq.2
UCSC ID: ENST00000238256.8_9
RefSeq Accession: NM_015258.2
Protein: Q5T1M5 (aka FKB15_HUMAN)

-  Gene Model Information
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-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.