ID:FCN2_HUMAN DESCRIPTION: RecName: Full=Ficolin-2; AltName: Full=37 kDa elastin-binding protein; AltName: Full=Collagen/fibrinogen domain-containing protein 2; AltName: Full=EBP-37; AltName: Full=Ficolin-B; AltName: Full=Ficolin-beta; AltName: Full=Hucolin; AltName: Full=L-ficolin; AltName: Full=Serum lectin p35; Flags: Precursor; FUNCTION: May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. SUBUNIT: Homopolymer; disulfide-linked. Interacts with elastin. Interacts with MASP1 and MASP2. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Expressed by the liver and secreted in plasma. DOMAIN: The fibrinogen-like domain (FBG) contains potential calcium-binding sites that may be involved in carbohydrate binding. SIMILARITY: Belongs to the ficolin lectin family. SIMILARITY: Contains 1 collagen-like domain. SIMILARITY: Contains 1 fibrinogen C-terminal domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15485
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK290843 - Homo sapiens cDNA FLJ75924 complete cds, highly similar to Homo sapiens ficolin (collagen/fibrinogen domain containing lectin)2 (hucolin) (FCN2), transcript variant SV0, mRNA. BC113935 - Homo sapiens ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), mRNA (cDNA clone IMAGE:40069277), complete cds. BC069572 - Homo sapiens ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), mRNA (cDNA clone MGC:97173 IMAGE:7262417), complete cds. BC069825 - Homo sapiens ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin), mRNA (cDNA clone MGC:97184 IMAGE:7262429), complete cds. D49353 - Homo sapiens mRNA for serum lectin P35, complete cds. JB054537 - Sequence 1 from Patent WO2012136585. E10706 - cDNA encoding 35kD protein having opsonin activity,P35. AK308476 - Homo sapiens cDNA, FLJ98517. JD436298 - Sequence 417322 from Patent EP1572962. AB590757 - Synthetic construct DNA, clone: pFN21AE1796, Homo sapiens FCN2 gene for ficolin (collagen/fibrinogen domain containing lectin) 2, without stop codon, in Flexi system. JD218650 - Sequence 199674 from Patent EP1572962. JD480318 - Sequence 461342 from Patent EP1572962. LF346361 - JP 2014500723-A/153864: Polycomb-Associated Non-Coding RNAs. JD561553 - Sequence 542577 from Patent EP1572962. JD197018 - Sequence 178042 from Patent EP1572962. JD275151 - Sequence 256175 from Patent EP1572962. JD388644 - Sequence 369668 from Patent EP1572962. JD242280 - Sequence 223304 from Patent EP1572962. MA581938 - JP 2018138019-A/153864: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q15485 (Reactome details) participates in the following event(s):
R-HSA-2855054 Ficolin-2 binds to molecular patterns on the target cell surface R-HSA-166726 Activation of MASPs R-HSA-166753 Conversion of C4 into C4a and C4b R-HSA-166792 Conversion of C2 into C2a and C2b R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface R-HSA-166662 Lectin pathway of complement activation R-HSA-166786 Creation of C4 and C2 activators R-HSA-166663 Initial triggering of complement R-HSA-166658 Complement cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
