ID:FBX18_HUMAN DESCRIPTION: RecName: Full=F-box only protein 18; EC=3.6.4.12; AltName: Full=F-box DNA helicase 1; FUNCTION: DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction. FUNCTION: Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: Part of a SCF E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXO18. Interacts with SKP1. SUBCELLULAR LOCATION: Nucleus (Probable). SIMILARITY: Belongs to the helicase family. UvrD subfamily. SIMILARITY: Contains 1 F-box domain. SEQUENCE CAUTION: Sequence=AAM73631.1; Type=Erroneous initiation; Sequence=BAB55073.1; Type=Erroneous initiation; Sequence=BAB55154.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8NFZ0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000724 double-strand break repair via homologous recombination GO:0000737 DNA catabolic process, endonucleolytic GO:0001934 positive regulation of protein phosphorylation GO:0006281 DNA repair GO:0006974 cellular response to DNA damage stimulus GO:0008219 cell death GO:0016567 protein ubiquitination GO:0031297 replication fork processing GO:0032508 DNA duplex unwinding GO:0035562 negative regulation of chromatin binding GO:0048478 replication fork protection GO:0072429 response to intra-S DNA damage checkpoint signaling GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage GO:2000042 negative regulation of double-strand break repair via homologous recombination
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
