Human Gene FAM186B (ENST00000257894.2_8) from GENCODE V47lift37
  Description: family with sequence similarity 186 member B, transcript variant 1 (from RefSeq NM_032130.3)
Gencode Transcript: ENST00000257894.2_8
Gencode Gene: ENSG00000135436.8_14
Transcript (Including UTRs)
   Position: hg19 chr12:49,981,288-49,999,422 Size: 18,135 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr12:49,981,388-49,999,260 Size: 17,873 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:49,981,288-49,999,422)mRNA (may differ from genome)Protein (893 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F186B_HUMAN
DESCRIPTION: RecName: Full=Protein FAM186B;
SIMILARITY: Belongs to the FAM186 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FAM186B
Diseases sorted by gene-association score: oropharynx cancer (5), polycystic kidney disease 4, with or without hepatic disease (1)

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.84 RPKM in Testis
Total median expression: 49.87 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.70162-0.356 Picture PostScript Text
3' UTR -20.20100-0.202 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q8IYM0
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0032991 macromolecular complex


-  Descriptions from all associated GenBank mRNAs
  AK302702 - Homo sapiens cDNA FLJ57285 complete cds.
AL713673 - Homo sapiens mRNA; cDNA DKFZp434N2350 (from clone DKFZp434N2350).
AL136748 - Homo sapiens mRNA; cDNA DKFZp434J0113 (from clone DKFZp434J0113).
BC035621 - Homo sapiens family with sequence similarity 186, member B, mRNA (cDNA clone MGC:44907 IMAGE:5171752), complete cds.
JD358348 - Sequence 339372 from Patent EP1572962.
AK093242 - Homo sapiens cDNA FLJ35923 fis, clone TESTI2010724.
AX748009 - Sequence 1534 from Patent EP1308459.
JD315977 - Sequence 297001 from Patent EP1572962.
JD232264 - Sequence 213288 from Patent EP1572962.
JD125493 - Sequence 106517 from Patent EP1572962.
AM393365 - Synthetic construct Homo sapiens clone IMAGE:100001743 for hypothetical protein (C12orf25 gene).

-  Other Names for This Gene
  Alternate Gene Symbols: B4DZ15, C12orf25, ENST00000257894.1, F186B_HUMAN, NM_032130, Q8IYM0, Q8TCP7, Q9H0L3, uc317fzz.1, uc317fzz.2
UCSC ID: ENST00000257894.2_8
RefSeq Accession: NM_032130.3
Protein: Q8IYM0 (aka F186B_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.