Human Gene FAM107A (ENST00000360997.7_14) from GENCODE V47lift37

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Description: family with sequence similarity 107 member A, transcript variant 2 (from RefSeq NM_001076778.3)
Gencode Transcript: ENST00000360997.7_14
Gencode Gene: ENSG00000168309.18_18
Transcript (Including UTRs)
Position: hg19 chr3:58,549,844-58,563,118 Size: 13,275 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr3:58,552,315-58,555,587 Size: 3,273 Coding Exon Count: 3

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:58,549,844-58,563,118)			mRNA (may differ from genome)		Protein (144 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: FAM107A Diseases sorted by gene-association score: renal cell carcinoma (6)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D002737 Chloroprene C028451 3,4,3',4'-tetrachlorobiphenyl D016604 Aflatoxin B1 D001151 Arsenic D001564 Benzo(a)pyrene D016572 Cyclosporine D003993 Dibutyl Phthalate D004041 Dietary Fats D004054 Diethylstilbestrol D004317 Doxorubicin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 375.11 RPKM in Brain - Anterior cingulate cortex (BA24) Total median expression: 3743.43 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-22.00	88	-0.250	Picture	PostScript	Text
3' UTR	-838.70	2471	-0.339	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009533 - DUF1151

Pfam Domains:
PF06625 - Protein of unknown function (DUF1151)

ModBase Predicted Comparative 3D Structure on Q6IAM1


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Cellular Component: GO:0016607 nuclear speck

Descriptions from all associated GenBank mRNAs


	AK054720 - Homo sapiens cDNA FLJ30158 fis, clone BRACE2000525, highly similar to Protein FAM107A. AF089853 - Homo sapiens DRR1 (DRR1) mRNA, complete cds. AF089854 - Homo sapiens cell-line OV177 DRR1 (DRR1) mRNA, complete cds. JD449441 - Sequence 430465 from Patent EP1572962. JD315139 - Sequence 296163 from Patent EP1572962. JD467811 - Sequence 448835 from Patent EP1572962. JD250992 - Sequence 232016 from Patent EP1572962. EU569833 - Homo sapiens family with sequence similarity 107 member A transcript variant (FAM107A) mRNA, complete cds, alternatively spliced. JD131308 - Sequence 112332 from Patent EP1572962. JD251574 - Sequence 232598 from Patent EP1572962. JD078896 - Sequence 59920 from Patent EP1572962. JD036862 - Sequence 17886 from Patent EP1572962. JD263700 - Sequence 244724 from Patent EP1572962. JD287612 - Sequence 268636 from Patent EP1572962. JD357545 - Sequence 338569 from Patent EP1572962. JD201160 - Sequence 182184 from Patent EP1572962. AB023811 - Homo sapiens mRNA for TU3A, complete cds. BC010561 - Homo sapiens family with sequence similarity 107, member A, mRNA (cDNA clone MGC:17126 IMAGE:4152118), complete cds. AL050264 - Homo sapiens mRNA; cDNA DKFZp564N0582 (from clone DKFZp564N0582). BC093012 - Homo sapiens cDNA clone IMAGE:30528214, containing frame-shift errors. AF035283 - Homo sapiens clone 23916 mRNA sequence. AK055443 - Homo sapiens cDNA FLJ30881 fis, clone FEBRA2004818, highly similar to DRR1 PROTEIN. AK128791 - Homo sapiens cDNA FLJ45473 fis, clone BRSTN2016992, highly similar to Protein FAM107A. JD343486 - Sequence 324510 from Patent EP1572962. JD516373 - Sequence 497397 from Patent EP1572962. JD059498 - Sequence 40522 from Patent EP1572962. JD310086 - Sequence 291110 from Patent EP1572962. JD154984 - Sequence 136008 from Patent EP1572962. JD392399 - Sequence 373423 from Patent EP1572962. JD177914 - Sequence 158938 from Patent EP1572962. JD076371 - Sequence 57395 from Patent EP1572962. JD122128 - Sequence 103152 from Patent EP1572962. JD252581 - Sequence 233605 from Patent EP1572962. JD415636 - Sequence 396660 from Patent EP1572962. AK316450 - Homo sapiens cDNA, FLJ79349 complete cds, highly similar to Protein FAM107A. JD332160 - Sequence 313184 from Patent EP1572962. JD353677 - Sequence 334701 from Patent EP1572962. AK298001 - Homo sapiens cDNA FLJ55230 complete cds, highly similar to Protein FAM107A. JD222072 - Sequence 203096 from Patent EP1572962. JD271257 - Sequence 252281 from Patent EP1572962. JD518558 - Sequence 499582 from Patent EP1572962. JD559482 - Sequence 540506 from Patent EP1572962. JD445861 - Sequence 426885 from Patent EP1572962. JD553945 - Sequence 534969 from Patent EP1572962. JD286965 - Sequence 267989 from Patent EP1572962. JD467804 - Sequence 448828 from Patent EP1572962. JD488037 - Sequence 469061 from Patent EP1572962. JD330582 - Sequence 311606 from Patent EP1572962. JD338107 - Sequence 319131 from Patent EP1572962. JD291290 - Sequence 272314 from Patent EP1572962. JD202142 - Sequence 183166 from Patent EP1572962. JD445730 - Sequence 426754 from Patent EP1572962. JD076745 - Sequence 57769 from Patent EP1572962. JD281700 - Sequence 262724 from Patent EP1572962. JD157688 - Sequence 138712 from Patent EP1572962. JD157125 - Sequence 138149 from Patent EP1572962. JD075378 - Sequence 56402 from Patent EP1572962. JD147563 - Sequence 128587 from Patent EP1572962. JD408591 - Sequence 389615 from Patent EP1572962. JD459101 - Sequence 440125 from Patent EP1572962. JD160505 - Sequence 141529 from Patent EP1572962. JD106281 - Sequence 87305 from Patent EP1572962. DQ891763 - Synthetic construct clone IMAGE:100004393; FLH179708.01X; RZPDo839B08132D family with sequence similarity 107, member A (FAM107A) gene, encodes complete protein. DQ894947 - Synthetic construct Homo sapiens clone IMAGE:100009407; FLH179704.01L; RZPDo839B08131D family with sequence similarity 107, member A (FAM107A) gene, encodes complete protein. JD264249 - Sequence 245273 from Patent EP1572962. KJ893246 - Synthetic construct Homo sapiens clone ccsbBroadEn_02640 FAM107A gene, encodes complete protein. AM393765 - Synthetic construct Homo sapiens clone IMAGE:100001735 for hypothetical protein (FAM107A gene). AB489168 - Synthetic construct DNA, clone: pF1KB8324, Homo sapiens FAM107A gene for family with sequence similarity 107, member A, without stop codon, in Flexi system. CR457133 - Homo sapiens full open reading frame cDNA clone RZPDo834F127D for gene TU3A, TU3A protein; complete cds, incl. stopcodon.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000360997.1, ENST00000360997.2, ENST00000360997.3, ENST00000360997.4, ENST00000360997.5, ENST00000360997.6, FAM107A , hCG_22019 , NM_001076778, Q6IAM1, Q6IAM1_HUMAN, TU3A , uc318buz.1, uc318buz.2 UCSC ID: ENST00000360997.7_14 RefSeq Accession: NM_001076778.3 Protein: Q6IAM1

Gene Model Information


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Methods, Credits, and Use Restrictions


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