ID:FAF2_HUMAN DESCRIPTION: RecName: Full=FAS-associated factor 2; AltName: Full=Protein ETEA; AltName: Full=UBX domain-containing protein 3B; AltName: Full=UBX domain-containing protein 8; FUNCTION: May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. SUBUNIT: Identified in a complex that contains SEL1L, OS9, FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with YOD1. SUBCELLULAR LOCATION: Cytoplasm. Lipid droplet. Endoplasmic reticulum. TISSUE SPECIFICITY: Broadly expressed, with highest levels in brain. MISCELLANEOUS: Up-regulated in T-cells and eosinophils from patients with atopic dermatitis. SIMILARITY: Contains 1 UBA domain. SIMILARITY: Contains 1 UBX domain. CAUTION: It seems odd to name this protein FAS-associated factor, but not have any mention of this in the CC lines.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96CS3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006986 response to unfolded protein GO:0030433 ER-associated ubiquitin-dependent protein catabolic process GO:0030970 retrograde protein transport, ER to cytosol GO:0034389 lipid particle organization GO:0043086 negative regulation of catalytic activity GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043312 neutrophil degranulation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
