ID:FAF1_HUMAN DESCRIPTION: RecName: Full=FAS-associated factor 1; Short=hFAF1; AltName: Full=UBX domain-containing protein 12; AltName: Full=UBX domain-containing protein 3A; FUNCTION: Potentiates but cannot initiate FAS-induced apoptosis. SUBUNIT: Specifically interacts with the cytoplasmic domain of FAS. Interacts with NLRP12 DAPIN/PYRIN domain via its UBA domain. SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Most abundant in testis, slightly less abundant in skeletal muscle and heart, followed by prostate, thymus, ovary, small intestine, and colon. Not detected in the peripheral blood leukocytes. SIMILARITY: Contains 1 UBA domain. SIMILARITY: Contains 1 UBX domain. SEQUENCE CAUTION: Sequence=AAD51876.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UNN5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006915 apoptotic process GO:0007253 cytoplasmic sequestering of NF-kappaB GO:0008219 cell death GO:0010942 positive regulation of cell death GO:0030155 regulation of cell adhesion GO:0031334 positive regulation of protein complex assembly GO:0042176 regulation of protein catabolic process GO:0043065 positive regulation of apoptotic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0045740 positive regulation of DNA replication GO:0045859 regulation of protein kinase activity GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1903364 positive regulation of cellular protein catabolic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
