Human Gene FABP5 (ENST00000297258.11_4) from GENCODE V47lift37
  Description: fatty acid binding protein 5 (from RefSeq NM_001444.3)
Gencode Transcript: ENST00000297258.11_4
Gencode Gene: ENSG00000164687.11_7
Transcript (Including UTRs)
   Position: hg19 chr8:82,192,771-82,197,010 Size: 4,240 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr8:82,192,831-82,196,802 Size: 3,972 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr8:82,192,771-82,197,010)mRNA (may differ from genome)Protein (135 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: FABP5_HUMAN
DESCRIPTION: RecName: Full=Fatty acid-binding protein, epidermal; AltName: Full=Epidermal-type fatty acid-binding protein; Short=E-FABP; AltName: Full=Fatty acid-binding protein 5; AltName: Full=Psoriasis-associated fatty acid-binding protein homolog; Short=PA-FABP;
FUNCTION: High specificity for fatty acids. Highest affinity for C18 chain length. Decreasing the chain length or introducing double bonds reduces the affinity. May be involved in keratinocyte differentiation.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Keratinocytes; highly expressed in psoriatic skin.
DOMAIN: Forms a beta-barrel structure that accommodates the hydrophobic ligand in its interior.
SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: FABP5
Diseases sorted by gene-association score: psoriasis (19), squamous cell carcinoma of the oral tongue (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 161.41 RPKM in Esophagus - Mucosa
Total median expression: 599.84 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -11.6060-0.193 Picture PostScript Text
3' UTR -32.00208-0.154 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012674 - Calycin
IPR011038 - Calycin-like
IPR000463 - Fatty_acid-bd
IPR000566 - Lipocln_cytosolic_FA-bd_dom

Pfam Domains:
PF00061 - Lipocalin / cytosolic fatty-acid binding protein family

SCOP Domains:
50814 - Lipocalins

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1B56 - X-ray MuPIT 1JJJ - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q01469
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005504 fatty acid binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0042802 identical protein binding

Biological Process:
GO:0006006 glucose metabolic process
GO:0006629 lipid metabolic process
GO:0006656 phosphatidylcholine biosynthetic process
GO:0008544 epidermis development
GO:0010829 negative regulation of glucose transport
GO:0019433 triglyceride catabolic process
GO:0042593 glucose homeostasis
GO:0043312 neutrophil degranulation

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0014069 postsynaptic density
GO:0030667 secretory granule membrane
GO:0035578 azurophil granule lumen
GO:0045202 synapse
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  LF211882 - JP 2014500723-A/19385: Polycomb-Associated Non-Coding RNAs.
AK226036 - Homo sapiens mRNA for Fatty acid-binding protein, epidermal variant, clone: FCC103B04.
AK311856 - Homo sapiens cDNA, FLJ92122, Homo sapiens fatty acid binding protein 5 (psoriasis-associated)(FABP5), mRNA.
BC070303 - Homo sapiens fatty acid binding protein 5 (psoriasis-associated), mRNA (cDNA clone MGC:88301 IMAGE:6496304), complete cds.
M94856 - Human fatty acid binding protein homologue (PA-FABP) mRNA, complete cds.
BC019385 - Homo sapiens fatty acid binding protein 5 (psoriasis-associated), mRNA (cDNA clone MGC:9003 IMAGE:3862100), complete cds.
LF208083 - JP 2014500723-A/15586: Polycomb-Associated Non-Coding RNAs.
LF210965 - JP 2014500723-A/18468: Polycomb-Associated Non-Coding RNAs.
DQ894470 - Synthetic construct Homo sapiens clone IMAGE:100008930; FLH170748.01L; RZPDo839B0299D fatty acid binding protein 5 (psoriasis-associated) (FABP5) gene, encodes complete protein.
DQ891285 - Synthetic construct clone IMAGE:100003915; FLH170752.01X; RZPDo839B02100D fatty acid binding protein 5 (psoriasis-associated) (FABP5) gene, encodes complete protein.
KJ896796 - Synthetic construct Homo sapiens clone ccsbBroadEn_06190 FABP5 gene, encodes complete protein.
BT007449 - Homo sapiens fatty acid binding protein 5 (psoriasis-associated) mRNA, complete cds.
LF342574 - JP 2014500723-A/150077: Polycomb-Associated Non-Coding RNAs.
LF371959 - JP 2014500723-A/179462: Polycomb-Associated Non-Coding RNAs.
LF342575 - JP 2014500723-A/150078: Polycomb-Associated Non-Coding RNAs.
LF371958 - JP 2014500723-A/179461: Polycomb-Associated Non-Coding RNAs.
LF377216 - JP 2014500723-A/184719: Polycomb-Associated Non-Coding RNAs.
LF371957 - JP 2014500723-A/179460: Polycomb-Associated Non-Coding RNAs.
LF342576 - JP 2014500723-A/150079: Polycomb-Associated Non-Coding RNAs.
LF371956 - JP 2014500723-A/179459: Polycomb-Associated Non-Coding RNAs.
MA578151 - JP 2018138019-A/150077: Polycomb-Associated Non-Coding RNAs.
MA607536 - JP 2018138019-A/179462: Polycomb-Associated Non-Coding RNAs.
MA578152 - JP 2018138019-A/150078: Polycomb-Associated Non-Coding RNAs.
MA607535 - JP 2018138019-A/179461: Polycomb-Associated Non-Coding RNAs.
MA607534 - JP 2018138019-A/179460: Polycomb-Associated Non-Coding RNAs.
MA578153 - JP 2018138019-A/150079: Polycomb-Associated Non-Coding RNAs.
MA607533 - JP 2018138019-A/179459: Polycomb-Associated Non-Coding RNAs.
MA447459 - JP 2018138019-A/19385: Polycomb-Associated Non-Coding RNAs.
MA443660 - JP 2018138019-A/15586: Polycomb-Associated Non-Coding RNAs.
MA446542 - JP 2018138019-A/18468: Polycomb-Associated Non-Coding RNAs.
MA612793 - JP 2018138019-A/184719: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q01469 (Reactome details) participates in the following event(s):

R-HSA-5622129 FABP5 binds atRA
R-HSA-5634100 FABP5 dissociates from RXRA:PPARD:atRA
R-HSA-5633256 FABP5:atRA translocates from cytosol to nucleoplasm
R-HSA-5334794 FABPs bind LCFAs
R-HSA-5422942 RXRA:PPARD binds FABP5:atRA
R-HSA-6798751 Exocytosis of azurophil granule lumen proteins
R-HSA-6798743 Exocytosis of secretory granule membrane proteins
R-HSA-5362517 Signaling by Retinoic Acid
R-HSA-163560 Triglyceride catabolism
R-HSA-9006931 Signaling by Nuclear Receptors
R-HSA-6798695 Neutrophil degranulation
R-HSA-8979227 Triglyceride metabolism
R-HSA-162582 Signal Transduction
R-HSA-168249 Innate Immune System
R-HSA-556833 Metabolism of lipids
R-HSA-168256 Immune System
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4K0, ENST00000297258.1, ENST00000297258.10, ENST00000297258.2, ENST00000297258.3, ENST00000297258.4, ENST00000297258.5, ENST00000297258.6, ENST00000297258.7, ENST00000297258.8, ENST00000297258.9, FABP5 , FABP5_HUMAN, NM_001444, Q01469, uc317lyy.1, uc317lyy.2
UCSC ID: ENST00000297258.11_4
RefSeq Accession: NM_001444.3
Protein: Q01469 (aka FABP5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.