Human Gene EXOC3L1 (ENST00000314586.11_8) from GENCODE V47lift37
  Description: exocyst complex component 3 like 1 (from RefSeq NM_178516.4)
Gencode Transcript: ENST00000314586.11_8
Gencode Gene: ENSG00000179044.16_13
Transcript (Including UTRs)
   Position: hg19 chr16:67,218,282-67,224,039 Size: 5,758 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg19 chr16:67,218,297-67,223,579 Size: 5,283 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:67,218,282-67,224,039)mRNA (may differ from genome)Protein (746 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: EX3L1_HUMAN
DESCRIPTION: RecName: Full=Exocyst complex component 3-like protein; AltName: Full=Protein Jiangli;
FUNCTION: As part of the exocyst, may play a role in regulated exocytosis of insulin granules (By similarity).
SUBUNIT: Interacts with EXOC2, EXOC4 and EXOC5; may be part of the exocyst (By similarity).
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle (By similarity). Note=Colocalizes with insulin granules (By similarity).
SIMILARITY: Belongs to the SEC6 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 36.82 RPKM in Spleen
Total median expression: 115.39 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -61.80173-0.357 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010326 - Sec6

Pfam Domains:
PF06046 - Exocyst complex component Sec6

SCOP Domains:
52425 - Cryptochrome/photolyase, N-terminal domain

ModBase Predicted Comparative 3D Structure on Q86VI1
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000149 SNARE binding
GO:0003674 molecular_function

Biological Process:
GO:0006887 exocytosis
GO:0030072 peptide hormone secretion
GO:0051601 exocyst localization

Cellular Component:
GO:0000145 exocyst
GO:0030133 transport vesicle
GO:0030141 secretory granule
GO:0031410 cytoplasmic vesicle


-  Descriptions from all associated GenBank mRNAs
  LF208269 - JP 2014500723-A/15772: Polycomb-Associated Non-Coding RNAs.
AK074090 - Homo sapiens mRNA for FLJ00161 protein.
AY255669 - Homo sapiens unknown mRNA.
LF208271 - JP 2014500723-A/15774: Polycomb-Associated Non-Coding RNAs.
BC034287 - Homo sapiens exocyst complex component 3-like, mRNA (cDNA clone IMAGE:5164368).
AK092858 - Homo sapiens cDNA FLJ35539 fis, clone SPLEN2002477, weakly similar to Rattus norvegicus (rsec6) mRNA.
AX747772 - Sequence 1297 from Patent EP1308459.
AK292004 - Homo sapiens cDNA FLJ76319 complete cds.
AK092906 - Homo sapiens cDNA FLJ35587 fis, clone SPLEN2007350.
AX747800 - Sequence 1325 from Patent EP1308459.
AK300915 - Homo sapiens cDNA FLJ55621 partial cds, weakly similar to Exocyst complex component 3.
BC167852 - Synthetic construct Homo sapiens clone IMAGE:100068242, MGC:195859 exocyst complex component 3-like (EXOC3L) mRNA, encodes complete protein.
JD157756 - Sequence 138780 from Patent EP1572962.
JD273920 - Sequence 254944 from Patent EP1572962.
JD158282 - Sequence 139306 from Patent EP1572962.
LF374048 - JP 2014500723-A/181551: Polycomb-Associated Non-Coding RNAs.
JD338660 - Sequence 319684 from Patent EP1572962.
MA443846 - JP 2018138019-A/15772: Polycomb-Associated Non-Coding RNAs.
MA443848 - JP 2018138019-A/15774: Polycomb-Associated Non-Coding RNAs.
MA609625 - JP 2018138019-A/181551: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K7I9, ENST00000314586.1, ENST00000314586.10, ENST00000314586.2, ENST00000314586.3, ENST00000314586.4, ENST00000314586.5, ENST00000314586.6, ENST00000314586.7, ENST00000314586.8, ENST00000314586.9, EX3L1_HUMAN, EXOC3L, NM_178516, Q86VI1, Q8NAD2, Q8TEN2, uc317pqv.1, uc317pqv.2
UCSC ID: ENST00000314586.11_8
RefSeq Accession: NM_178516.4
Protein: Q86VI1 (aka EX3L1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.