Human Gene ETV3 (ENST00000368192.9_7) from GENCODE V47lift37

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Description: ETS variant transcription factor 3, transcript variant 1 (from RefSeq NM_001145312.3)
Gencode Transcript: ENST00000368192.9_7
Gencode Gene: ENSG00000117036.12_9
Transcript (Including UTRs)
Position: hg19 chr1:157,090,983-157,108,187 Size: 17,205 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr1:157,094,633-157,106,144 Size: 11,512 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:157,090,983-157,108,187)			mRNA (may differ from genome)		Protein (512 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: ETV3_HUMAN DESCRIPTION: RecName: Full=ETS translocation variant 3; AltName: Full=ETS domain transcriptional repressor PE1; Short=PE-1; AltName: Full=Mitogenic Ets transcriptional suppressor; FUNCTION: Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity. SUBCELLULAR LOCATION: Nucleus (Potential). SIMILARITY: Belongs to the ETS family. SIMILARITY: Contains 1 ETS DNA-binding domain. SEQUENCE CAUTION: Sequence=AAA60949.1; Type=Frameshift; Positions=174;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ETV3 Diseases sorted by gene-association score: subclavian steal syndrome (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) C027576 4-hydroxy-2-nonenal D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D005839 Gentamicins D008070 Lipopolysaccharides D012999 Soman C018021 cobaltous chloride C024989 coenzyme Q10 C045651 epigallocatechin gallate C069837 fullerene C60 C028007 nickel monoxide C006253 pirinixic acid C027373 potassium chromate(VI) D020122 tert-Butylhydroperoxide

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 16.92 RPKM in Skin - Sun Exposed (Lower leg) Total median expression: 209.81 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-31.40	93	-0.338	Picture	PostScript	Text
3' UTR	-1076.80	3650	-0.295	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000418 - Ets
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF00178 - Ets-domain

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on P41162


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003674 molecular_function GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0017151 DEAD/H-box RNA helicase binding GO:0043565 sequence-specific DNA binding Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0008150 biological_process GO:0008285 negative regulation of cell proliferation GO:0030154 cell differentiation GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus Cellular Component: GO:0000790 nuclear chromatin GO:0005634 nucleus GO:0017053 transcriptional repressor complex GO:0090571 RNA polymerase II transcription repressor complex

Descriptions from all associated GenBank mRNAs


	LF206158 - JP 2014500723-A/13661: Polycomb-Associated Non-Coding RNAs. LF352057 - JP 2014500723-A/159560: Polycomb-Associated Non-Coding RNAs. LF352056 - JP 2014500723-A/159559: Polycomb-Associated Non-Coding RNAs. LF352055 - JP 2014500723-A/159558: Polycomb-Associated Non-Coding RNAs. LF352054 - JP 2014500723-A/159557: Polycomb-Associated Non-Coding RNAs. LF352053 - JP 2014500723-A/159556: Polycomb-Associated Non-Coding RNAs. LF352052 - JP 2014500723-A/159555: Polycomb-Associated Non-Coding RNAs. AK316274 - Homo sapiens cDNA, FLJ79173 complete cds, highly similar to ETS translocation variant 3. AK304789 - Homo sapiens cDNA FLJ54664 complete cds, highly similar to ETS translocation variant 3. AB527832 - Synthetic construct DNA, clone: pF1KB7786, Homo sapiens ETV3 gene for ets variant 3, without stop codon, in Flexi system. L16464 - Human ETS oncogene (PEP1) mRNA, complete cds. AF218540 - Homo sapiens short mitogenic Ets transcriptional suppressor METS mRNA, complete cds. BC022868 - Homo sapiens ets variant 3, mRNA (cDNA clone IMAGE:4107340), complete cds. DQ893155 - Synthetic construct clone IMAGE:100005785; FLH194418.01X; RZPDo839B0280D ets variant gene 3 (ETV3) gene, encodes complete protein. DQ896758 - Synthetic construct Homo sapiens clone IMAGE:100011218; FLH194414.01L; RZPDo839B0270D ets variant gene 3 (ETV3) gene, encodes complete protein. LF352049 - JP 2014500723-A/159552: Polycomb-Associated Non-Coding RNAs. LF352047 - JP 2014500723-A/159550: Polycomb-Associated Non-Coding RNAs. LF352045 - JP 2014500723-A/159548: Polycomb-Associated Non-Coding RNAs. JD141667 - Sequence 122691 from Patent EP1572962. MA587634 - JP 2018138019-A/159560: Polycomb-Associated Non-Coding RNAs. MA587633 - JP 2018138019-A/159559: Polycomb-Associated Non-Coding RNAs. MA587632 - JP 2018138019-A/159558: Polycomb-Associated Non-Coding RNAs. MA587631 - JP 2018138019-A/159557: Polycomb-Associated Non-Coding RNAs. MA587630 - JP 2018138019-A/159556: Polycomb-Associated Non-Coding RNAs. MA587629 - JP 2018138019-A/159555: Polycomb-Associated Non-Coding RNAs. MA587626 - JP 2018138019-A/159552: Polycomb-Associated Non-Coding RNAs. MA587624 - JP 2018138019-A/159550: Polycomb-Associated Non-Coding RNAs. MA587622 - JP 2018138019-A/159548: Polycomb-Associated Non-Coding RNAs. MA441735 - JP 2018138019-A/13661: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_etsPathway - METS affect on Macrophage Differentiation

Other Names for This Gene


	Alternate Gene Symbols: B4E3M7, ENST00000368192.1, ENST00000368192.2, ENST00000368192.3, ENST00000368192.4, ENST00000368192.5, ENST00000368192.6, ENST00000368192.7, ENST00000368192.8, ETV3_HUMAN, METS, NM_001145312, P41162, PE1, Q8TAC8, Q9BX30, uc318gof.1, uc318gof.2 UCSC ID: ENST00000368192.9_7 RefSeq Accession: NM_001145312.3 Protein: P41162 (aka ETV3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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