ID:ERF1_HUMAN DESCRIPTION: RecName: Full=Eukaryotic peptide chain release factor subunit 1; Short=Eukaryotic release factor 1; Short=eRF1; AltName: Full=Protein Cl1; AltName: Full=TB3-1; FUNCTION: Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. SUBUNIT: Heterodimer of two subunits, one of which binds GTP. Component of the transient SURF (SMG1-UPF1-eRF1-eRF3) complex. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the eukaryotic release factor 1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P62495
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC014269 - Homo sapiens eukaryotic translation termination factor 1, mRNA (cDNA clone MGC:10451 IMAGE:3677482), complete cds. X81625 - H.sapiens mRNA for Cl1 protein. JD195691 - Sequence 176715 from Patent EP1572962. JD508485 - Sequence 489509 from Patent EP1572962. JD563902 - Sequence 544926 from Patent EP1572962. JD539094 - Sequence 520118 from Patent EP1572962. JD224545 - Sequence 205569 from Patent EP1572962. JD039725 - Sequence 20749 from Patent EP1572962. JD279424 - Sequence 260448 from Patent EP1572962. JD081852 - Sequence 62876 from Patent EP1572962. JD343340 - Sequence 324364 from Patent EP1572962. JD362937 - Sequence 343961 from Patent EP1572962. JD556877 - Sequence 537901 from Patent EP1572962. JD059249 - Sequence 40273 from Patent EP1572962. JD097865 - Sequence 78889 from Patent EP1572962. JD196440 - Sequence 177464 from Patent EP1572962. JD250105 - Sequence 231129 from Patent EP1572962. JD493013 - Sequence 474037 from Patent EP1572962. JD276831 - Sequence 257855 from Patent EP1572962. JD195992 - Sequence 177016 from Patent EP1572962. JD440251 - Sequence 421275 from Patent EP1572962. JD254741 - Sequence 235765 from Patent EP1572962. M75715 - Human TB3-1 mRNA, complete cds. X80916 - H.sapiens HCGVII mRNA. JD230436 - Sequence 211460 from Patent EP1572962. JD060495 - Sequence 41519 from Patent EP1572962. JD305673 - Sequence 286697 from Patent EP1572962. JD236702 - Sequence 217726 from Patent EP1572962. JD423298 - Sequence 404322 from Patent EP1572962. AK302364 - Homo sapiens cDNA FLJ56175 complete cds, highly similar to Eukaryotic peptide chain release factor subunit1. BC088358 - Homo sapiens eukaryotic translation termination factor 1, mRNA (cDNA clone MGC:111066 IMAGE:30389626), complete cds. JD114166 - Sequence 95190 from Patent EP1572962. JD332135 - Sequence 313159 from Patent EP1572962. JD144111 - Sequence 125135 from Patent EP1572962. DQ890706 - Synthetic construct clone IMAGE:100003336; FLH165324.01X; RZPDo839A11160D eukaryotic translation termination factor 1 (ETF1) gene, encodes complete protein. BT007374 - Homo sapiens eukaryotic translation termination factor 1 mRNA, complete cds. AK312510 - Homo sapiens cDNA, FLJ92875, Homo sapiens eukaryotic translation termination factor 1 (ETF1),mRNA. U90176 - Human eukaryotic release factor 1 eRF1 mRNA, complete cds. DQ893890 - Synthetic construct Homo sapiens clone IMAGE:100008350; FLH165320.01L; RZPDo839A11159D eukaryotic translation termination factor 1 (ETF1) gene, encodes complete protein. AK309875 - Homo sapiens cDNA, FLJ99916. JD393876 - Sequence 374900 from Patent EP1572962. JD475921 - Sequence 456945 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P62495 (Reactome details) participates in the following event(s):
R-HSA-927832 UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex R-HSA-927789 Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex R-HSA-927889 SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) R-HSA-6800138 N6AMT1:TRMT112 transfers CH3 group from AdoMet to ETF1 dimer R-HSA-141691 GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex R-HSA-141673 GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex R-HSA-141671 Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) R-HSA-376176 Signaling by ROBO receptors R-HSA-927802 Nonsense-Mediated Decay (NMD) R-HSA-72764 Eukaryotic Translation Termination R-HSA-422475 Axon guidance R-HSA-8953854 Metabolism of RNA R-HSA-72766 Translation R-HSA-1266738 Developmental Biology R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
