ID:ERC2_HUMAN DESCRIPTION: RecName: Full=ERC protein 2; FUNCTION: Thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act together with BSN. May recruit liprin-alpha proteins to the CAZ. SUBUNIT: Interacts with BSN, ERC1, PPFIA1, PPFIA2, PPFIA3 and PPFIA4. Interacts through its C-terminus with the PDZ domain of RIMS1. Part of a complex consisting of ERC2, RIMS1 and UNC13A. INTERACTION: P10242:MYB; NbExp=2; IntAct=EBI-2684336, EBI-298355; SUBCELLULAR LOCATION: Cytoplasm. Cell junction, synapse. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=In neurons, localized to synapses, and colocalizes with PCLO. Localized to the active zone of presynaptic density (By similarity). SEQUENCE CAUTION: Sequence=BAA20832.2; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF10174 - RIM-binding protein of the cytomatrix active zone
SCOP Domains: 90257 - Myosin rod fragments 57997 - Tropomyosin
ModBase Predicted Comparative 3D Structure on O15083
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB002376 - Homo sapiens mRNA for KIAA0378 gene. BC060881 - Homo sapiens cDNA clone IMAGE:30335913. BC068563 - Homo sapiens cDNA clone IMAGE:30341203. BC094783 - Homo sapiens cDNA clone IMAGE:30528232. BC111550 - Homo sapiens ELKS/RAB6-interacting/CAST family member 2, mRNA (cDNA clone MGC:133063 IMAGE:40008953), complete cds. BC112391 - Homo sapiens ELKS/RAB6-interacting/CAST family member 2, mRNA (cDNA clone MGC:133064 IMAGE:40008962), complete cds. AB383865 - Synthetic construct DNA, clone: pF1KSDA0378, Homo sapiens ERC2 gene for ELKS/RAB6-interacting/CAST family member 2, complete cds, without stop codon, in Flexi system. BC046212 - Homo sapiens mRNA similar to cytomatrix protein p110 (cDNA clone IMAGE:6192926). JD364247 - Sequence 345271 from Patent EP1572962. JD447806 - Sequence 428830 from Patent EP1572962. JD341257 - Sequence 322281 from Patent EP1572962.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
