ID:EMIL2_HUMAN DESCRIPTION: RecName: Full=EMILIN-2; AltName: Full=Elastin microfibril interface-located protein 2; Short=Elastin microfibril interfacer 2; AltName: Full=Protein FOAP-10; Flags: Precursor; FUNCTION: May be responsible for anchoring smooth muscle cells to elastic fibers, and may be involved not only in the formation of the elastic fiber, but also in the processes that regulate vessel assembly. Has cell adhesive capacity. SUBUNIT: Homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing the nucleation of the triple helix and then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds (By similarity). Interacts with EMILIN1. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix. Note=Found mainly at the interface between amorphous elastin and microfibrils. TISSUE SPECIFICITY: Highest levels are present in fetal heart and adult lung. Intermediate levels in peripheral leukocytes, placenta, and spinal cord and low expression in fetal brain, spleen, thymus, and lung and in adult heart, aorta, testis, bone marrow, small intestine, thymus, lymph node, and appendix. SIMILARITY: Contains 1 C1q domain. SIMILARITY: Contains 1 collagen-like domain. SIMILARITY: Contains 1 EMI domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 103657 - BAR/IMD domain-like 140453 - EsxAB dimer-like 46966 - Spectrin repeat 49842 - TNF-like 90257 - Myosin rod fragments 57959 - Leucine zipper domain 57997 - Tropomyosin 58010 - Fibrinogen coiled-coil and central regions 111474 - Coronavirus S2 glycoprotein 161270 - PspA lactotransferrin-binding region 58100 - Bacterial hemolysins 58104 - Methyl-accepting chemotaxis protein (MCP) signaling domain
ModBase Predicted Comparative 3D Structure on Q9BXX0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
